Protein Alignment Br140 and Brpf1

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_006237117.1
• Gene: Brpf1 / 679713
• RGDID: 1584828
• Length: 1252
• Species: Rattus norvegicus
• Alignment Length: 1536
• Identity: 562/1536 - (36%)
• Similarity: 747/1536 - (48%)
• Gaps: 414/1536 - (26%)

  Fly     1 MGLDFDAVEYCKGVKTQQSQPPFACPVRGCDRSYKTIMGLQYHLMKYDHDNPQPLTPVLTPSRKK 65
            ||:|||...:|..::.  ::||:.|||..|.:.||:..|::|||..||||:|.|  |..||.||.
  Rat     1 MGVDFDVKTFCHNLRA--TKPPYECPVETCRKVYKSYSGIEYHLYHYDHDSPPP--PQQTPLRKH 61

  Fly    66 ARSRSGGHHSTPRPHKDHPTPGGGGAEARNGCSSASAGGGSASGVSARQYANPESLVSYNEEEAT 130
            .:.   |..|.| .:|..|:|           |..|...|             ..::||.:.:..
  Rat    62 KKK---GRQSRP-ANKQSPSP-----------SEVSQSPG-------------REVMSYAQAQRM 98

  Fly   131 VTFNLDGKSVRLGIDDALPLVEDEEFAALVARGCILNADAPPLEEN-----APWARVQ------- 183
            |..:|.|:..|:.|.|.|.:|.::|.|.         .:||....|     .|.|..:
  Rat    99 VEVDLHGRVHRISIFDNLDVVSEDEEAP---------EEAPENGSNKENTETPAATPKSGKHKNK 154

  Fly   184 ------------VPVARVAEIPD--YR-----VSDAPPRPLAYYRFIEKSLEELDGEVEYDVDEE 229
                        .|.:...::|:  ||     ..||||||.:|||:||||.||||.|||||:|||
  Rat   155 EKRKDSNHHHHSAPASAAPKLPEVVYRELDQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEE 219

  Fly   230 DSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESHFQAAANGTPTGVEVDDDAVCCICLDGEC 294
            |..||:.|||.|:..|::.:..:..|.|||||||||:|::...|.|..: ||:|||||||.||||
  Rat   220 DYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNAL-VDEDAVCCICNDGEC 283

  Fly   295 QNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKPVNCVLCPNAGGAFKQTDHGQWA 359
            ||:|||||||||||||||:||||||||||||||||||||||:.|:|.||||.||||||||.|:||
  Rat   284 QNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWA 348

  Fly   360 HVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGLGACIQCHRNSCYAAFHVTCA 424
            |||||||||||.||||||||||||||.||||||:||||:||::|.|||||||:.:||.|||||||
  Rat   349 HVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCA 413

  Fly   425 QQAGLYMTMDTVKD-GHNDSSMHVQKFAYCHAHTPADAKLKM----------NVPDFED------ 472
            |||||||.|:.|:: |.|.:|..|:|.|||..|||..:..::          ...:.||
  Rat   414 QQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEEEDEEEDEGKSWS 478

  Fly   473 ----------TRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKKEFLDRIIAYW 527
                      :|.|||:|||.||:||:.||||.:|.|||.|:.:|...:|:|||.:|:.|:.:||
  Rat   479 SEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYW 543

  Fly   528 TLKRHYRNGVPLLRRLQSQGNNHGVIQRN----GIEGSPDTGELYRQLKYWQCLRQDLERARLLC 588
            ||||..|||||||||||:    |...|||    |.:.......|..|||.||.||.||||||||.
  Rat   544 TLKRQSRNGVPLLRRLQT----HLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERARLLV 604

  Fly   589 ELVRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTS------EVPD 647
            ||:|||||||...::|.:..:.:||.|....|.|.|:.|:.:|:..||.|||..|      ||||
  Rat   605 ELIRKREKLKRETIKIQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVTELDEVPD 669

  Fly   648 YTDIVKQPMDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLF 712
            |.|.:|:|||..||:..|:..:|.:.:..|.||:|::.|||.||.|||:||||.:|:|:|...:.
  Rat   670 YLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVL 734

  Fly   713 VQVRKELQRDGL-----------LARSQ-RYHVDHVEAE------------VEQELRLLLAAPAS 753
            .|.|::.::.|:           ||..: .:|.:.||.|            ||::|:|||
  Rat   735 RQARRQAEKMGIDFETGMHIPHNLAGDEVSHHTEDVEEERLVLLENQKHLPVEEQLKLLL----- 794

  Fly   754 EGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEISRMRKSLQKARFAARHSSHANQSQSDDEDTL 818
                ::|    |:....|....|:::.|.|:.|::.:|:.|          :|..::..|..:
  Rat   795 ----ERL----DEVNASKQSVGRSRRAKMIKKEMTALRRKL----------AHQRETGRDGPE-- 839

  Fly   819 GGSPSKKRTRKRFNSSGVDMELGH----DDDDEEEDSDEDSMGEDTVSKDLLNSTQTPPCSPIKS 879
                       |...||......|    |.|.:.:.:.|:|..::| ||.|         .|
  Rat   840 -----------RHGPSGRGNLTPHPAACDKDGQTDSAAEESSSQET-SKGL---------GP--- 880

  Fly   880 LNNSSSPV-GINRRTAILLTRKAQAALKRPSEPLTTPVKEEQHNSQSSNTQSTSGSSSSVTTAAT 943
             |.||:|. .:.|||::|.::|.......|..|...|     .|.:|..|.|..||
  Rat   881 -NMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPP-----KNRESQMTPSHGGS--------- 930

  Fly   944 AASSGAGTLNHVLSSAPPTASSFALTQNNSSGGGALASGTGIGGSSSAGTAAAASLTSTALAMNS 1008
                         ...||
  Rat   931 -------------PVGPP----------------------------------------------- 935

  Fly  1009 KLSANLPVKSPKRPGRYRRVPEVRHSS-SMSPKKSPNPAVTVSQALPMPETLPF-------ERIP 1065
                .||:....|..:..|.|....|| |.|.|.:.:|          |..||.       :.:.
  Rat   936 ----QLPIMGSLRQRKRGRSPRPSSSSDSDSDKSTEDP----------PMDLPANGFSSGNQPVK 986

  Fly  1066 DSFRVYR--ANNQRDVSDSDDAPSQSSSPCSSCSDFSMSGSCSDFDSDEASEGDADGDPDRDGGR 1128
            .||.|||  .|..|..|||:.:.|.|||..|
  Rat   987 KSFLVYRNDCNLPRSSSDSESSSSSSSSAAS---------------------------------- 1017

  Fly  1129 SRSEERDSTSQEGTTDAMDMQHASLNNVQGNNGNMAISSSSGGSGGSSSEDDELEERPLSARQNK 1193
                :|.||:                  ....|....|.|.|.....||||       .|..:|:
  Rat  1018 ----DRTSTT------------------PSKQGRGKPSFSRGTFPEDSSED-------TSGTENE 1053

  Fly  1194 PMKVGTRGTPTPTTMARAVALSAGRGRG-------KRRSNLSESTSSTATPPPLRRAGKLRSATP 1251
            ...|||                 |||.|       .:...|.....|.|:||         :|.|
  Rat  1054 AYSVGT-----------------GRGVGHSSKYPHPKSGVLGTQFQSLASPP---------AADP 1092

  Fly  1252 NASPLVNNIKARRNTTAAGSAPLTNNNRSKHSEDSASSERHNNHSHGQKPALEPLQLVWAKCRGY 1316
              |||..:.:..|.:...|:..|        |||..|             .|:.|.|||||||||
  Rat  1093 --SPLSRSCEVVRKSLGRGAGWL--------SEDEDS-------------PLDALDLVWAKCRGY 1134

  Fly  1317 PWYPALILDPKTPK-GFVYNGVPLPAPPTDVLALRKNCLDEI---VFLVLFFDVKRTWQWLPANK 1377
            |.|||||:|||.|: |..::|||:|.||.:||.|.:....|.   ::||||||.||||||||..|
  Rat  1135 PSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTK 1199

  Fly  1378 LDILGIDKQLDQQKLVESRKPAERKAVKKAYQDALHYQSQV 1418
            |..||:::.||::|::|.||...||:|:.||..||.::|:|
  Rat  1200 LVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRSKV 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516	18/38 (47%)
		COG5141	203..>625	CDD:227470	267/452 (59%)
		Bromo_brd1_like	615..712	CDD:99944	45/102 (44%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	12/82 (15%)
		PWWP_BRPF	1303..1414	CDD:438964	63/114 (55%)
Brpf1	XP_006237117.1	SFP1	<20..50	CDD:227516	15/29 (52%)
		COG5141	173..656	CDD:227470	280/487 (57%)
		ePHD_BRPF1	329..449	CDD:277171	89/119 (75%)
		Bromo_brd1_like	631..734	CDD:99944	45/102 (44%)
		PWWP_BRPF1	1121..1240	CDD:438984	64/118 (54%)