Protein Alignment Br140 and Jade3

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001393168.1
• Gene: Jade3 / 382207
• MGIID: 2148019
• Length: 850
• Species: Mus musculus
• Alignment Length: 1106
• Identity: 266/1106 - (24%)
• Similarity: 402/1106 - (36%)
• Gaps: 366/1106 - (33%)

  Fly   106 SASGVSARQYANPESLVSYNE---EEATVTFNLDGKSVRLGID-DALPLVEDEEFAALVARGCIL 166
            ||..:....:.||:|...:.:   ||..       |.|::..: |::|.      .:|.:|...|
Mouse    51 SAMKIPDSHHVNPDSYYLFTDTWKEEWE-------KGVQVPANPDSVPT------PSLRSRNRTL 102

  Fly   167 NADAPPLEENAPWARVQVPVARVAEIPDYRVSDAP------PRPLAYYR----------FIEKSL 215
            .....|...:.|          |.::|..|:....      .||..|.|          :| .:|
Mouse   103 PTPQKPFFCSLP----------VTDLPHRRIISEKVKEMLFVRPRKYIRCSSPESAEPGYI-NTL 156

  Fly   216 EELDGEVEYDVDEEDSAWLEHMNEERQRLGLNAVGIDTMELLMDRLEKESH---FQAAANGTPTG 277
            |:......||:|:.|..||:.:||:...:|...:....||..::.||:..|   ..|.......|
Mouse   157 EQAASTCRYDLDDMDIFWLQELNEDLGEMGYGPIDETLMEKTIEVLERHCHENMNHAIETVEGLG 221

  Fly   278 VEVDDDAVCCICLDGECQNTNVILFCDMCNLAVHQDCYGVPYIPEGQWLCRRCLQS--PSKPVNC 340
            :|.|:|.:|.:|...:.:..|.::|||.||:.|||.|||:..||||.||||.|:..  |    .|
Mouse   222 IEYDEDVICDVCRSPDSEEGNDMVFCDKCNVCVHQACYGILKIPEGSWLCRSCVLGIYP----QC 282

  Fly   341 VLCPNAGGAFKQTDHG-QWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKGL 404
            ||||..|||.|.|..| :||||.||||||||..|....:||:..|..|||:||.|.|.:||.| .
Mouse   283 VLCPKKGGAMKTTRTGTKWAHVSCALWIPEVSIACPERMEPVTKISHIPPSRWALVCNLCKLK-T 346

  Fly   405 GACIQCHRNSCYAAFHVTCAQQAGLYMTMDTVKDGHNDSSMHVQKFAYCHAHTPADAKLKMNVPD 469
            ||||||...||..|||||||.:.||  .|.|:.|..::    |:..::|..|:....||    .|
Mouse   347 GACIQCSVKSCITAFHVTCAFEHGL--EMKTILDEGDE----VKFKSFCLKHSQNKPKL----GD 401

  Fly   470 FEDTRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQ---RKKEF----LDRIIAYW 527
            .|...|::.|..:|.::|.|.....|     .:..:|..|:|.::   ::.|.    :|.|..||
Mouse   402 AEYHHHRVAEQSQAKSEKTSLRAQKL-----RELEEEFYTLVQVEDVAKEMELSAFTVDFIYNYW 461

  Fly   528 TLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDLERARLLCELVR 592
            .|||......||:...:.:.|  |::|       |....::.:::.:..|||||||.|.||.::.
Mouse   462 KLKRKSNFNKPLIPPKEEEEN--GLVQ-------PKEESIHTRMRMFMHLRQDLERVRNLCYMIS 517

  Fly   593 KREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQPMD 657
            :|||||::..::.|::..||                    :|:..|.:...
Mouse   518 RREKLKLSHTKVQEQIFGLQ--------------------VQLINEEITEG-------------- 548

  Fly   658 LGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQRD 722
                                    |.:.|.|    ::::||
Mouse   549 ------------------------LSLTNAL----ENSLFY------------------------ 561

  Fly   723 GLLARSQRYHVDHVEAEVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRLEI 787
                                                             .|...|.|:|
Mouse   562 -------------------------------------------------PPPRITLKLK------ 571

  Fly   788 SRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEEDSD 852
              |.||                                                         :.
Mouse   572 --MPKS---------------------------------------------------------TS 577

  Fly   853 EDSMGEDTVSKDLLNSTQTPPCSPIKSLNNSSSPVGINRRTAILLTRKAQAALKRPSEPLTTPVK 917
            ||       .||....|:....||     .|||| |.::|:.           :.|.|||...||
Mouse   578 ED-------CKDSSTETEHQLSSP-----GSSSP-GHSKRSP-----------QMPEEPLDMNVK 618

  Fly   918 -------EEQHNS-QSSNTQS-TSGSSSSVTTAATAASSGAGTLNHVLSSAPPTASSFALTQNNS 973
                   |.:.|. |:|.:.| ....|||.|..|.:|.     ..|..|...|.|...||....|
Mouse   619 IYPRYPLESKSNCLQTSRSHSRCETKSSSPTPRAPSAE-----FYHGQSLGKPLALQAALHGQVS 678

  Fly   974 SGGG------ALASGTGIGGSSSAGTAAAASLTSTALAMNSKLSANLPVKSPKRPGRYRRVPEVR 1032
            .|.|      .::|..|:.|:.|.......:.:.......|.||::||     .||..|: ..:.
Mouse   679 IGNGKNQPNSRVSSSNGLEGNWSGNITQKVNSSEVCYDQESMLSSHLP-----SPGNIRK-SSME 737

  Fly  1033 HSSSMSPKKSPNPAVTVSQALPMPETLPFERIPDSFRVYRANNQRDVSDSDDAPSQS--SSPCSS 1095
            | .|.|.|::.|..|..::.|.                |.....::||..:....:.  ..|...
Mouse   738 H-FSRSFKEATNTWVKPTEDLQ----------------YCVKPTKNVSSKEQLWGRQLLRRPTGR 785

  Fly  1096 CSDFSMSGSCSDFDSDEASEGDADGDPDRDGGRSR--SEERDSTSQE------GTTDAMDMQHAS 1152
            .|.....|.|.|.   |.|:.:|:|:..::..|.:  |.:|::.|.:      |.|......|:|
Mouse   786 ASYQETDGYCPDL---EPSDSEAEGEGSKETPRVKRESSDRENPSHDSARECHGKTKTHPHSHSS 847

  Fly  1153 L 1153
            :
Mouse   848 M 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	155/444 (35%)
		Bromo_brd1_like	615..712	CDD:99944	7/96 (7%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	18/84 (21%)
		PWWP_BRPF	1303..1414	CDD:438964
Jade3	NP_001393168.1	EPL1	<74..204	CDD:463128	33/153 (22%)
		COG5141	165..>536	CDD:227470	146/399 (37%)
		PHD_SF	282..392	CDD:473978	59/116 (51%)