Protein Alignment Br140 and Alh

DIOPT Version :10

• Sequence 1: NP_610266.1
• Gene: Br140 / 35648
• FlyBaseID: FBgn0033155
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_061503484.1
• Gene: Alh / 1281722
• VectorBaseID: AGAMI1_006379
• Length: 2496
• Species: Anopheles gambiae
• Alignment Length: 1125
• Identity: 234/1125 - (20%)
• Similarity: 373/1125 - (33%)
• Gaps: 339/1125 - (30%)

  Fly   286 CCICLDGECQNTNVILFCD--MCNLAVHQDCYGVPYIPEGQWLCRRCLQSPSKP--VNCVLCPNA 346
            ||:|.|....:.|.:::||  .|.:||||.|||:..:|.|.|.||:| :|..:|  |.|.|||:.
Mosquito     8 CCVCSDDRGWSENPLVYCDGQSCAVAVHQACYGIVTVPSGPWYCRKC-ESQERPARVRCELCPSR 71

  Fly   347 GGAFKQTDHGQWAHVVCALWIPEVRFANTVFLEPIDSIETIPPARWRLTCYVCKEKG------LG 405
            .||.|:||:..||||||||:||||||.|...:||| .::.||..|:..|||:|::.|      :|
Mosquito    72 DGALKRTDNQGWAHVVCALYIPEVRFGNVTTMEPI-ILQLIPQERYNKTCYICQDMGKGSRANVG 135

  Fly   406 ACIQCHRNSCYAAFHVTCAQQAGLYMT-----MDTVKDGHNDSSMHVQKFAYCHAHTPADAKLK- 464
            ||:||:::.|...||||||||.||...     :|.||           ...||..|.   :|||
Mosquito   136 ACMQCNKSGCKQQFHVTCAQQLGLLCEEAGNYLDNVK-----------YCGYCQHHY---SKLKK 186

  Fly   465 ----MNVPDFEDTRHKMKEARKALAKKRSTAPVVLIPTIPPDRVQEIATMVTMQRKKEFLDRIIA 525
                ..:|.::...|:...:....:.::...|       ||
Mosquito   187 GGNVKTIPPYKPISHEANSSDGPSSPEKEMEP-------PP------------------------ 220

  Fly   526 YWTLKRHYRNGVPLLRRLQSQGNNHGVIQRNGIEGSPDTGELYRQLKYWQCLRQDLERARLLCEL 590
                        |......|...:.|.....|..|...:|
Mosquito   221 ------------PQQHSSSSAAGSGGTGGGGGGGGGGGSG------------------------- 248

  Fly   591 VRKREKLKVAFVRISEEVVMLQLNPLEAALNKLLDALEARDSMQIFREPVDTSEVPDYTDIVKQP 655
                                        |......:...:.|.::..||
Mosquito   249 ----------------------------AGGSSSSSSGLKSSSRLSGEP---------------- 269

  Fly   656 MDLGTMRAKLKECQYNSLEQLEADFDLMIQNCLAYNNKDTVFYRAGIRMRDQAAPLFVQVRKELQ 720
             .:|...:.......:|.:|.::          :..:|.:....:|..:...::
Mosquito   270 -SVGGSSSTSSSSSSSSSKQRKS----------SSASKSSSGSGSGASLSSSSS----------- 312

  Fly   721 RDGLLARSQRYHVDHVEAEVEQELRLLLAAPASEGIVQKLLILADKSQVLKNPTYRTKKIKQIRL 785
             ..:||..                    ....|.|        :..|.:..|.:..|........
Mosquito   313 -SSVLASG--------------------GGGGSGG--------SGASGMSGNSSMSTSSSSSSSS 348

  Fly   786 EISRMRKSLQKARFAARHSSHANQSQSDDEDTLGGSPSKKRTRKRFNSSGVDMELGHDDDDEEED 850
            .:|.|..|  ....:..:|..:....|....::|||.|.|.:.   .|||.....|.......::
Mosquito   349 GVSSMSGS--GGSGSVSNSGGSGIGGSGIAGSVGGSGSSKTSS---GSSGGTGGGGGSSGSSSKE 408

  Fly   851 SDEDSMGEDTVSKDLLNSTQTPPCSPIKS-LNNSSSPVGINRRTAILLTRKAQAALKRPSEPL-- 912
            .|:.|...|..||...:|:.:.......| .|||:|            |..:.......|:.:
Mosquito   409 KDKYSKNRDKSSKSSKSSSSSSTSGGSGSNFNNSTS------------TSSSAGGSSNQSKDVDM 461

  Fly   913 --TTPVKEEQHNSQSSNTQSTSGSSSSVTTAATAASSGAGTLNHVLSSAPPTASS---FALTQNN 972
              |.........:..:|..|.|.|.|..::.|....||.|..:...|.:...:||   .......
Mosquito   462 GGTAGSSSGSMGALGANASSQSSSQSGYSSTAGGGGSGPGGSSSSSSGSSSNSSSKHHSDKPDKG 526

  Fly   973 SSGGGALASGTG-IGGSSSAGTAAAASLTSTALAMNSKLSANLPVKSPKRPGRYRRVPEVRHSSS 1036
            |.|||:.:.|.| :..:|..|:..||||:..|      :...|.:|.|:           .|:..
Mosquito   527 SGGGGSSSQGGGPLSTNSGVGSGRAASLSPAA------IPTTLIIKPPQ-----------DHTGG 574

  Fly  1037 MSPKKSPNPAVT-VSQALPMPETLPFERIPDSFRVYR-----ANNQRDVS--------------- 1080
            ...:.....|:. :|.:....||:    :.:|..||.     :.|....|
Mosquito   575 SGKEPLSKEAIAKMSTSSNFTETI----VVNSESVYNHAGSGSGNAGSTSVIESGKLAMGGSGAG 635

  Fly  1081 -----------------DSDDAPSQSSS------------PCSSCSDFSMSGSCSDFDSDEA--- 1113
                             .|..:.|.|||            |.||.|...|..:..|...|.|
Mosquito   636 SGGSGGSYGGSTGPTGGSSTGSSSSSSSGGKKRKADARSTPTSSVSSSEMLDANRDLIRDVAVSL 700

  Fly  1114 -----SEGDADGDPDRDGGRSRSEERDSTSQEGTTDAM------------DMQHASLNNVQGNNG 1161
                 |:.| ..||.......:|.::..|.   |:..:            ::|:.:.|.:|..:.
Mosquito   701 VPLSLSKND-HIDPSSIASHEKSVKKAKTE---TSSPLPHPATALPAPEPNLQNVTPNLIQSAHT 761

  Fly  1162 NMAISSSSGGSGGSSSEDDELE-------------ERPLSARQNKPMKVGTRGTPTPTTMARAVA 1213
            :..|||:|..|..|||...:.:             ::|.|::....:.|   ..|..|.....|.
Mosquito   762 SSIISSASSSSASSSSGKHQQQQQHHHHQPTPHSPQQPASSQHTPSLVV---SVPLSTATVPGVN 823

  Fly  1214 LSAGRGRGKRRSNLSESTSSTATPPPLRRAGKLRSATPN-ASPLVNNIKARRNTTAAGSAPLTNN 1277
            |.|...........|.|:||:::......|....::||| .||  .:.:........|.:.:.||
Mosquito   824 LPASNNSNSSSHTGSSSSSSSSSSNVNHSASSNSNSTPNIVSP--GHHQGSDRGGGGGGSHINNN 886

  Fly  1278 NRSKHSEDSASSERHNNHSH 1297
            |.:.:|....:|..:...||
Mosquito   887 NNNSNSNSGGNSNLYQQISH 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Br140	NP_610266.1	SFP1	<22..61	CDD:227516
		COG5141	203..>625	CDD:227470	96/358 (27%)
		Bromo_brd1_like	615..712	CDD:99944	9/96 (9%)
		MSCRAMM_ClfA	<1080..1163	CDD:468110	24/146 (16%)
		PWWP_BRPF	1303..1414	CDD:438964
Alh	XP_061503484.1	None