Protein Alignment Tsp42Ef and CD63

DIOPT Version :10

• Sequence 1: NP_523632.2
• Gene: Tsp42Ef / 35615
• FlyBaseID: FBgn0033127
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_001771.1
• Gene: CD63 / 967
• HGNCID: 1692
• Length: 238
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 59/248 - (23%)
• Similarity: 103/248 - (41%)
• Gaps: 50/248 - (20%)

  Fly     1 MASTSSVKLIVYALDVLCTLLA-------LVLISFGIYVAVSYNLNE---IGQLTAYGYVGLGAA 55
            ||....:|.:.:.|.||  |||       |:.:..|..:.:|..:.:   .|.|.....:.:|..
Human     1 MAVEGGMKCVKFLLYVL--LLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVF 63

  Fly    56 ALLVVLWGYLSAWRENVCCTVTFIIFLCLVIIAQFAVVYL-LITQEKTVA---SNLANALEATWE 116
            ..||...|...|.:||.|..:||.|||.|:::.:.|.... .:.::|.::   :|....:| .:.
Human    64 LFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQME-NYP 127

  Fly   117 EELNSPGAMSLYQNWFQCCGRGSPQDYIVNERLP-------PETCFRNHDKSKPENLIHTGCRVE 174
            :..::...:...|..|:|||..:..|:   |::|       |::|..|         :..||.:.
Human   128 KNNHTASILDRMQADFKCCGAANYTDW---EKIPSMSKNRVPDSCCIN---------VTVGCGIN 180

  Fly   175 FENYWQH-----------LTKIFNILALVLIGF---ELLLSVISCRLCNSIRN 213
            |.....|           |.|...::|...:|.   |:|..|.:|.|..|||:
Human   181 FNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRS 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ef	NP_523632.2	Tetraspanin	7..209	CDD:459767	54/236 (23%)
CD63	NP_001771.1	Tetraspanin	10..229	CDD:459767	53/233 (23%)
		CD63_LEL	105..203	CDD:239419	20/110 (18%)
		Lysosomal targeting motif. /evidence=ECO:0000250|UniProtKB:P41731	234..238		59/248 (24%)