Protein Alignment Tsp42Ef and TSPAN8

DIOPT Version :10

• Sequence 1: NP_523632.2
• Gene: Tsp42Ef / 35615
• FlyBaseID: FBgn0033127
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_004607.1
• Gene: TSPAN8 / 7103
• HGNCID: 11855
• Length: 237
• Species: Homo sapiens
• Alignment Length: 225
• Identity: 56/225 - (24%)
• Similarity: 102/225 - (45%)
• Gaps: 28/225 - (12%)

  Fly     1 MASTSS-VKLIVYALDVLCTLLALVLISFGIYVAVS------YNLNEIGQLTAYG---YVGLGAA 55
            ||..|: :|..::..:.|..|..:::::..|:|.||      :...::|..:...   .:.:||.
Human     1 MAGVSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAI 65

  Fly    56 ALLVVLWGYLSAWRENVCCTVTFIIFLCLVIIAQFAVVYLLITQEKTVASNLAN--------ALE 112
            .:::...|...|.:|:.|..:.|.|.|.|:::.|.| ..:|....|:.:..:.|        .|.
Human    66 IMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVA-TGILGAVFKSKSDRIVNETLYENTKLLS 129

  Fly   113 ATWEEELNSPGAMSLYQNWFQCCGR-GSPQDYIVNERLPPETCFRNHDKSKPENLIHTGCRVEFE 176
            ||.|.|.....|:.::|..|:|||. ....|:..|.:..||.| ...||.:|.. .:.|.:|..|
Human   130 ATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELC-ACLDKQRPCQ-SYNGKQVYKE 192

  Fly   177 NYWQHLTKIFNILA---LVLIGFELLLSVI 203
            ..   ::.|.:.||   :::||....|:||
Human   193 TC---ISFIKDFLAKNLIIVIGISFGLAVI 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ef	NP_523632.2	Tetraspanin	7..209	CDD:459767	53/218 (24%)
TSPAN8	NP_004607.1	Tetraspanin	8..232	CDD:459767	53/218 (24%)
		hydrophobic region	10..33		3/22 (14%)
		hydrophobic region	58..78		3/19 (16%)
		hydrophobic region	83..109		8/26 (31%)
		TM4SF3_like_LEL	106..206	CDD:239407	27/104 (26%)
		hydrophobic region	206..232		5/14 (36%)