Protein Alignment Tsp42Ef and PRPH2

DIOPT Version :10

• Sequence 1: NP_523632.2
• Gene: Tsp42Ef / 35615
• FlyBaseID: FBgn0033127
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_000313.2
• Gene: PRPH2 / 5961
• HGNCID: 9942
• Length: 346
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 48/273 - (17%)
• Similarity: 93/273 - (34%)
• Gaps: 82/273 - (30%)

  Fly     7 VKLI--VYALDVLCTLLALVLISFGIYVAVSYNL------NEIGQLTAYGYVGLGAA-------- 55
            |||.  ::.::....|..:::.|.|:::.:....      |..........:|:|..
Human    14 VKLAQGLWLMNWFSVLAGIIIFSLGLFLKIELRKRSDVMNNSESHFVPNSLIGMGVLSCVFNSLA 78

  Fly    56 ------ALLVVLWGYLSAW-RENVCCTVTFIIFLCLVIIAQFAVVYLLITQEKTVASNLANALEA 113
                  ||....:.....| :..:...|.|.|.|.||.:..|   .|..:.|.|:...|.|.::
Human    79 GKICYDALDPAKYARWKPWLKPYLAICVLFNIILFLVALCCF---LLRGSLENTLGQGLKNGMK- 139

  Fly   114 TWEEELNSPG------AMSLYQNWFQCCGRGSPQDYI----------------VNERL------- 149
             :..:.::||      .:.:.|..|:|||....:|:.                |.:|:
Human   140 -YYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGR 203

  Fly   150 --------------PPETCFR----------NHDKSKPE-NLIHTGCRVEFENYWQHLTKIFNIL 189
                          .|..|.:          ::|....| ||...|||....:|:..|.....::
Human   204 YLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLMNSMGVV 268

  Fly   190 ALVLIGFELLLSV 202
            .|::..||:.:::
Human   269 TLLIWLFEVTITI 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ef	NP_523632.2	Tetraspanin	7..209	CDD:459767	48/273 (18%)
PRPH2	NP_000313.2	Tetraspanin	16..181	CDD:459767	30/169 (18%)
		peripherin_like_LEL	120..262	CDD:239415	26/146 (18%)
		Interaction with MREG. /evidence=ECO:0000250	341..346