Protein Alignment vimar and RAP1GDS1

DIOPT Version :10

• Sequence 1: NP_995767.1
• Gene: vimar / 35609
• FlyBaseID: FBgn0022960
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001093896.1
• Gene: RAP1GDS1 / 5910
• HGNCID: 9859
• Length: 608
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 186/630 - (29%)
• Similarity: 318/630 - (50%)
• Gaps: 72/630 - (11%)

  Fly     6 IDDLIEKLKTTSVSPANTT-----NLLCEISATKDPKLFDKHE---LAECFLGLTKCDDTNVRKE 62
            :.|.::|||.|:|.....:     :.|.:..|..:.:..:|.:   :.:.|..|. ...::.:.:
Human     5 LSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLL-TPQSSCKAK 68

  Fly    63 AAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDEARDLI 127
            .|..|||:.|:|..|.......:|:..::.|     :....|:.:|..||||||||.:.|.|..:
Human    69 VANIIAEVAKNEFMRIPCVDAGLISPLVQLL-----NSKDQEVLLQTGRALGNICYDSHEGRSAV 128

  Fly   128 LELEGDAVLL-RLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGIIDI 191
            .:..|..::: .|..:.:|.|.|| .:.:.|..|:|.||....:.|..:.:.:||:..|..::.|
Human   129 DQAGGAQIVIDHLRSLCSITDPAN-EKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGI 192

  Fly   192 GASNVEQHEDLLLNTLPLLSILTENVSDLNFDSSLNI--QLSRILAASTNPDLAEMCLELLHYQA 254
            ...|....|..|:    ....|.|..|.....:|.||  :|.::.......|..||..|:|...|
Human   193 HCQNAALTEMCLV----AFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA 253

  Fly   255 ESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDSMHYLY---TTP 316
            |:|.:||.|.:.||.|.:..:::: |..:...:....:|...:|:||:|.||:||..|:   ...
Human   254 ENDAIKLQLVEAGLVECLLEIVQQ-KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGS 317

  Fly   317 LLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNNGVKD-DVRLQH 380
            :.:.::.|:.|.:..|...|.||:.||||.|::||:.|:...:.||:::|.::  |:| :|.:||
Human   318 VFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRH--VEDGNVTVQH 380

  Fly   381 ALLSALRNLVIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELLKNK 445
            |.|||||||.||..||..::.||:.:.:|..|:...|||.|||||||||.:|.|.:.|.:|.||.
Human   381 AALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNV 445

  Fly   446 TLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIADKIPLTQDYDR 510
            .|:|:||.|.::.|:|||.|||.||::.||:|:                              ..
Human   446 KLVERLVEWCEAKDHAGVMGESNRLLSALIRHS------------------------------KS 480

  Fly   511 SSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQA--------QLLQD 567
            ..:.:.:...|.::.:|:|.|::|::||||||:||.:::.:.|....:..::        :||.|
Human   481 KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLLAD 545

  Fly   568 ELVKCEVGKKLAELIS--KSSDTMTKEIVENLQ--NCVNLLKSSE 608
            |....|:......||.  ..|:.:.|| |::|.  :.|:.|:|.|
Human   546 ERSAPEIKYNSMVLICALMGSECLHKE-VQDLAFLDVVSKLRSHE 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vimar	NP_995767.1	armadillo repeat	77..118	CDD:293788	11/40 (28%)
		armadillo repeat	124..165	CDD:293788	10/41 (24%)
		armadillo repeat	318..343	CDD:293788	6/24 (25%)
		armadillo repeat	351..391	CDD:293788	18/40 (45%)
		armadillo repeat	396..428	CDD:293788	14/31 (45%)
RAP1GDS1	NP_001093896.1	PLN03200	19..>265	CDD:215629	63/256 (25%)
		armadillo repeat	45..76	CDD:293788	6/31 (19%)
		armadillo repeat	92..117	CDD:293788	8/29 (28%)
		armadillo repeat	125..168	CDD:293788	12/43 (28%)
		ARM	347..390	CDD:214547	19/44 (43%)
		chemoreceptor_sensor	<362..445	CDD:444710	41/84 (49%)