Protein Alignment vimar and Rap1gds1

DIOPT Version :10

• Sequence 1: NP_995767.1
• Gene: vimar / 35609
• FlyBaseID: FBgn0022960
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: NP_001035780.1
• Gene: Rap1gds1 / 229877
• MGIID: 2385189
• Length: 607
• Species: Mus musculus
• Alignment Length: 634
• Identity: 192/634 - (30%)
• Similarity: 322/634 - (50%)
• Gaps: 77/634 - (12%)

  Fly     6 IDDLIEKLKTTSVSPANTT--------NLLCEISATKDPKLFDKHE---LAECFLGLTKCDDTNV 59
            :|:|.:.||...::.|:.|        :.|.:..|..:.:..:|.:   :.:.|..|. ....:.
Mouse     1 MDNLSDTLKKLKITAADRTEGSLEGCLDCLLQALAQNNAETSEKIQGSGILQLFANLL-TPQASC 64

  Fly    60 RKEAAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDEAR 124
            ..:.|..|||:.|:|..|.......:|:..::.|     :....|:.:|..||||||||.:.|.|
Mouse    65 TAKVADIIAEVAKNEFMRIPCVDAGLISPLVQLL-----NSKDQEVLLQTGRALGNICYDSHEGR 124

  Fly   125 DLILELEGDAVLL-RLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGI 188
            ..:.:..|..::: .|..:....|.| :.:.:.|..|:|.||....:.|..:.:.:||:..|..:
Mouse   125 SAVDQAGGAQIVIDHLRSLCGRTDPA-SEKLMTVFCGMLMNYSNENDSLQAQLISMGVIPTLVKL 188

  Fly   189 IDIGASNVEQHEDLLLNTLPLLSILTENVSDLNFDSSLNI--QLSRILAASTNPDLAEMCLELLH 251
            :.|...|....|..|:    ....|.|..|.....:|.||  :|.::.......|..||..|:|.
Mouse   189 LGIHCHNAALTEMCLV----AFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLA 249

  Fly   252 YQAESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDSMHYLY--- 313
            ..||:|.:||.|.:.||.|.:..:::: |..::..:..|.:|.|.:|:||:|.||:||..|:
Mouse   250 PLAENDAIKLQLVEAGLVECLLEIVQQ-KVDSNKEDDVAELKTASDLMVLLLLGDESMQKLFEGG 313

  Fly   314 TTPLLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNNGVKD-DVR 377
            ...:.:.::.|:.|.:..|...|.||:.||||.|.:||:.|:...:.||:::|.::  |:| :|.
Mouse   314 KGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDGNCIHMVDNGIVEKLMDLLDRH--VEDGNVT 376

  Fly   378 LQHALLSALRNLVIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELL 442
            :|||.|||||||.||..||..::.||:.:|:|..|:...|||.|||||||||.:|.|.:.|.:|.
Mouse   377 VQHAALSALRNLAIPVVNKAKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLG 441

  Fly   443 KNKTLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIADKIPLTQD 507
            ||..|:|:||.|.::.|:|||.|||.||::.||:|:
Mouse   442 KNAKLVERLVEWCEAKDHAGVMGESNRLLSALIRHS----------------------------- 477

  Fly   508 YDRSSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSE--AAQAQLLQ---- 566
             ....:.:.:...|.::.:|:|.|::|::||||||:||.:::.:.|. |:|  .|.|||:|
Mouse   478 -KSKDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELG-PAEKDLASAQLVQILHR 540

  Fly   567 ---DELVKCEVGKKLAELIS--KSSDTMTKEIVENLQ--NCVNLLKSSE 608
               ||....|:......||.  ..|:::.|| |::|.  :.|:.|:|.|
Mouse   541 LLADERSAPEIKYNSMVLICALMGSESLYKE-VQDLAFLDVVSKLRSHE 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vimar	NP_995767.1	armadillo repeat	77..118	CDD:293788	11/40 (28%)
		armadillo repeat	124..165	CDD:293788	8/41 (20%)
		armadillo repeat	318..343	CDD:293788	6/24 (25%)
		armadillo repeat	351..391	CDD:293788	18/40 (45%)
		armadillo repeat	396..428	CDD:293788	15/31 (48%)
Rap1gds1	NP_001035780.1	PLN03200	42..>264	CDD:215629	59/232 (25%)
		armadillo repeat	44..71	CDD:293788	4/27 (15%)
		Arm	86..117	CDD:425727	9/35 (26%)
		ARM 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00259	89..131		14/46 (30%)
		armadillo repeat	91..116	CDD:293788	8/29 (28%)
		Prevents binding to prenylated RHOA. /evidence=ECO:0000250|UniProtKB:P52306	122..170		11/48 (23%)
		armadillo repeat	124..167	CDD:293788	10/43 (23%)
		ARM 2. /evidence=ECO:0000255	170..211		9/44 (20%)
		ARM	346..389	CDD:214547	19/44 (43%)
		ARM 3. /evidence=ECO:0000255	347..390		20/44 (45%)
		chemoreceptor_sensor	<361..444	CDD:444710	42/84 (50%)
		ARM 4. /evidence=ECO:0000255	391..431		20/39 (51%)
		ARM 5. /evidence=ECO:0000255	479..519		13/39 (33%)