Protein Alignment coro and CORO2A

DIOPT Version :10

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_003380.3
• Gene: CORO2A / 7464
• HGNCID: 2255
• Length: 525
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 207/511 - (40%)
• Similarity: 317/511 - (62%)
• Gaps: 34/511 - (6%)

  Fly     7 RSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGRIA 71
            ||||||||:|:...:|.|||::.:::|..|:.||||||.|:|::.|.||||||:|:|.::.|::.
Human     8 RSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLD 72

  Fly    72 ADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGL 136
            ..:|.|.||:|.|||:.|.|.:|..|||.|||..:|:|.||...|:|.||....:||.|.|||||
Human    73 PHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGL 137

  Fly   137 VLWHPSALNVLLTAGSDNQVVIWNVGTGEILV-----HIDSHPDIVYSACFNWDGSKLVTTCKDK 196
            |.|||:|.|:|.:||.|.:|:|||:.|.|.::     .|..|.|::.|..||.:||.|.|||||:
Human   138 VEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVILSMSFNTNGSLLATTCKDR 202

  Fly   197 KIRIYDPRTAELESEAMCHEGSKATRAIFLRH-GLIFTTGFNRSSERQYSLRAPDALNEPIVMVE 260
            |||:.|||...:..|| .::|.:|::.:||.: ..:.:||.:|.:.||.:|...|.|:.|::..:
Human   203 KIRVIDPRAGTVLQEA-SYKGHRASKVLFLGNLKKLMSTGTSRWNNRQVALWDQDNLSVPLMEED 266

  Fly   261 LDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRGCD 325
            ||.|:||:||.|||||:|:|:.||||..|||:||:.:.|.:.|:..:::..||:|||:|||||.|
Human   267 LDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKPHLSYLTEYRSYNPQKGIGVMPKRGLD 331

  Fly   326 VTTCEVAKFYRM-NNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFS 389
            |::||:.:||:: ....|.:.|||.|||:|:.:|||:||.|.....::||:||:.|.:.|||..|
Human   332 VSSCEIFRFYKLITTKSLIEPISMIVPRRSESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVS 396

  Fly   390 LKDRVSIVQGGYVSSS---VNKSLPAKKAGNILNKPRGDSASSGATSSS---------AGGGNFA 442
            |:....:::...:.:.   .|...||  :..:||:....:|..|..|||         |......
Human   397 LRPGSELLRPHPLPAERPIFNSMAPA--SPRLLNQTEKLAAEDGWRSSSLLEEKMPRWAAEHRLE 459

  Fly   443 S-----GNNNEASEGGPPAAVLSEKDLRTI----QDEIRKLKAIIVKQENRIRALE 489
            .     .|..:..|..||.   :|.:|..:    |:|||:|:.::.::|.:.:.||
Human   460 EKKTWLTNGFDVFECPPPK---TENELLQMFYRQQEEIRRLRELLTQREVQAKQLE 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	WD40	9..>392	CDD:475233	180/389 (46%)
		WD40 repeat	37..78	CDD:293791	19/40 (48%)
		WD40 repeat	85..129	CDD:293791	20/43 (47%)
		WD40 repeat	134..171	CDD:293791	19/41 (46%)
		WD40 repeat	178..213	CDD:293791	18/34 (53%)
		WD40 repeat	220..260	CDD:293791	12/40 (30%)
		WD40 repeat	267..308	CDD:293791	21/40 (53%)
CORO2A	NP_003380.3	WD40	10..518	CDD:475233	205/509 (40%)
		WD 1	24..71		23/46 (50%)
		WD40 repeat	40..80	CDD:293791	20/39 (51%)
		WD 2	72..122		23/49 (47%)
		WD40 repeat	86..130	CDD:293791	20/43 (47%)
		WD repeat	130..170		22/39 (56%)
		WD40 repeat	135..170	CDD:293791	19/34 (56%)
		WD 4	171..214		20/42 (48%)
		WD40 repeat	184..219	CDD:293791	19/35 (54%)
		WD repeat	220..263		13/42 (31%)
		WD40 repeat	225..266	CDD:293791	12/40 (30%)
		WD repeat	269..308		22/38 (58%)
		WD40 repeat	273..312	CDD:293791	21/38 (55%)