Protein Alignment coro and Coro1b

DIOPT Version :10

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_062095.2
• Gene: Coro1b / 29474
• RGDID: 2382
• Length: 484
• Species: Rattus norvegicus
• Alignment Length: 504
• Identity: 272/504 - (53%)
• Similarity: 354/504 - (70%)
• Gaps: 27/504 - (5%)

  Fly     1 MSFR-VVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPH 64
            |||| |||.||||||:||.:|.:|||::||||:.:||||||||||||||:|||::|||||:|||.
  Rat     1 MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPL 65

  Fly    65 NKVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVF 129
            ||.|||...:|.|.||.||||||.||||||.|||||||||.|.|||||:.||:..||||||.|..
  Rat    66 NKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEG 130

  Fly   130 HQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDS-HPDIVYSACFNWDGSKLVTTC 193
            |.:|||::.|||:|.||||:||.||.|:||||||.|.|..:|| |||::|:..:|.:||...|.|
  Rat   131 HTKRVGIITWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCTAC 195

  Fly   194 KDKKIRIYDPRTAELESE-AMCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIV 257
            |||.:||.|||...|.:| ...|||::..|||||..|.:|||||:|.||||.:|..|:...||:.
  Rat   196 KDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENFEEPMA 260

  Fly   258 MVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKR 322
            :.|||:|||.:.|.||.||:::|:||||||.|||||:|.|||::|::|||.:.|||||:|.||||
  Rat   261 LQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPPYIHFLNTFTSKEPQRGMGSMPKR 325

  Fly   323 GCDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPIT 387
            |.:|:.||:|:||:::.. .|:.|.|||||||||||:||||||...|||:.||:|:.|:|||||.
  Rat   326 GLEVSKCEIARFYKLHER-KCEPIVMTVPRKSDLFQDDLYPDTAGPDAALEAEDWVSGQDADPIL 389

  Fly   388 FSLKDRVSIVQGGYVSSSVNKSLPAKKAGNIL--NKPRGDSASSGATSSSAGGGNFASGNNNEAS 450
            .||::       .||.|. .:.|...:. |:|  :||.|.|.|..:|:::.  .:..|||...:.
  Rat   390 ISLRE-------AYVPSK-QRDLKVSRR-NVLSDSKPAGYSRSGVSTATAI--TDIPSGNLAGSG 443

  Fly   451 EGGPPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAKEDARNKNG 499
            |.|         .|..:..|:|.|:.::.:|..||..|| :...|.:||
  Rat   444 EAG---------KLEEVMQELRALRVLVKEQGERISRLE-EHLGRMENG 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	WD40	9..>392	CDD:475233	236/384 (61%)
		WD40 repeat	37..78	CDD:293791	29/40 (73%)
		WD40 repeat	85..129	CDD:293791	33/43 (77%)
		WD40 repeat	134..171	CDD:293791	23/36 (64%)
		WD40 repeat	178..213	CDD:293791	16/35 (46%)
		WD40 repeat	220..260	CDD:293791	20/39 (51%)
		WD40 repeat	267..308	CDD:293791	24/40 (60%)
Coro1b	NP_062095.2	WD40	10..480	CDD:475233	263/491 (54%)
		WD40 repeat	38..80	CDD:293791	30/41 (73%)
		WD 1	80..120		31/39 (79%)
		WD40 repeat	86..130	CDD:293791	33/43 (77%)
		WD 2	130..170		25/39 (64%)
		WD40 repeat	135..172	CDD:293791	23/36 (64%)
		WD 3	174..213		18/38 (47%)
		WD40 repeat	180..215	CDD:293791	16/34 (47%)
		WD 4	217..260		23/42 (55%)
		WD40 repeat	223..263	CDD:293791	20/39 (51%)
		WD 5	265..305		25/39 (64%)
		WD40 repeat	270..311	CDD:293791	24/40 (60%)