Protein Alignment coro and Coro1b

DIOPT Version :10

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_035908.1
• Gene: Coro1b / 23789
• MGIID: 1345963
• Length: 484
• Species: Mus musculus
• Alignment Length: 502
• Identity: 269/502 - (53%)
• Similarity: 352/502 - (70%)
• Gaps: 23/502 - (4%)

  Fly     1 MSFR-VVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPH 64
            |||| |||.||||||:||.:|.:|||::||||:.:||||||||||||||:|||::|||||:|||.
Mouse     1 MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFMVLPL 65

  Fly    65 NKVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVF 129
            ||.|||...:|.|.||.||||||.||||||.|||||||||.|.|||||:.||:..||||||.|..
Mouse    66 NKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEG 130

  Fly   130 HQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDS-HPDIVYSACFNWDGSKLVTTC 193
            |.:|||::.|||:|.||||:||.||.|:||||||.|.|..:|| |||::|:..:|.:||...:.|
Mouse   131 HTKRVGIITWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSAC 195

  Fly   194 KDKKIRIYDPRTAELESE-AMCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIV 257
            |||.:||.|||...|.:| ...|||::..|||||..|.:|||||:|.||||.:|..|:.|.||:.
Mouse   196 KDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEPMA 260

  Fly   258 MVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKR 322
            :.|||:|||.:.|.||.||:::|:||||||.|||||:|.|||::|::|||.:.|||||:|.||||
Mouse   261 LQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEPPYIHFLNTFTSKEPQRGMGSMPKR 325

  Fly   323 GCDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPIT 387
            |.:|:.||:|:||:::.. .|:.|.|||||||||||:||||||...:||:.||:|:.|:||:||.
Mouse   326 GLEVSKCEIARFYKLHER-KCEPIVMTVPRKSDLFQDDLYPDTAGPEAALEAEDWVSGQDANPIL 389

  Fly   388 FSLKDRVSIVQGGYVSSSVNKSLPAKKAGNILNKPRGDSASSGATSSSAGGGNFASGNNNEASEG 452
            .||::       .||.|. .:.|...:. |:|:..|..|.|....|::....:..|||...|.|.
Mouse   390 ISLRE-------AYVPSK-QRDLKVSRR-NVLSDSRPASYSRSGASTATAVTDVPSGNLAGAGEA 445

  Fly   453 GPPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAKEDARNKNG 499
            |         .|..:..|:|.|:.::.:|..||..|| ::..|.:||
Mouse   446 G---------KLEEVMQELRALRMLVKEQGERISRLE-EQLGRMENG 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	WD40	9..>392	CDD:475233	234/384 (61%)
		WD40 repeat	37..78	CDD:293791	29/40 (73%)
		WD40 repeat	85..129	CDD:293791	33/43 (77%)
		WD40 repeat	134..171	CDD:293791	23/36 (64%)
		WD40 repeat	178..213	CDD:293791	15/35 (43%)
		WD40 repeat	220..260	CDD:293791	21/39 (54%)
		WD40 repeat	267..308	CDD:293791	24/40 (60%)
Coro1b	NP_035908.1	WD40	10..480	CDD:475233	260/489 (53%)
		WD40 repeat	38..80	CDD:293791	30/41 (73%)
		WD 1	80..120		31/39 (79%)
		WD40 repeat	86..130	CDD:293791	33/43 (77%)
		WD 2	130..170		25/39 (64%)
		WD40 repeat	135..172	CDD:293791	23/36 (64%)
		WD 3	174..213		17/38 (45%)
		WD40 repeat	180..215	CDD:293791	15/34 (44%)
		WD 4	217..260		24/42 (57%)
		WD40 repeat	223..263	CDD:293791	21/39 (54%)
		WD 5	265..305		25/39 (64%)
		WD40 repeat	270..311	CDD:293791	24/40 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..446		12/42 (29%)