Protein Alignment coro and CORO1C

DIOPT Version :10

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001098707.1
• Gene: CORO1C / 23603
• HGNCID: 2254
• Length: 527
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 265/494 - (53%)
• Similarity: 341/494 - (69%)
• Gaps: 38/494 - (7%)

  Fly     4 RVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVG 68
            ||||.||||||:|||:|.:||||:||||:.:|||:||||||:|:|||:|::|||||:|||.:|.|
Human    56 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTG 120

  Fly    69 RIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRR 133
            ||...:|.|.||.||||||.||||||.|||||||||.|.|||||:.||:.:||||||.|..|.:|
Human   121 RIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKR 185

  Fly   134 VGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDS-HPDIVYSACFNWDGSKLVTTCKDKK 197
            ||:|.|||:|.||||:||.||.::||||||||.|:::|. |.|::|:..:|.:||.:.|..||||
Human   186 VGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKK 250

  Fly   198 IRIYDPRTAELESE-AMCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIVMVEL 261
            :|:.|||..|:.:| ...|||::..|||||..|.:|||||:|.||||.:|..|..:.|||.:.|:
Human   251 VRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEM 315

  Fly   262 DTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKRGCDV 326
            ||||||:.|.||.||::|||||||||.|||||:|.|.|:|||:|||.:.|||||:|.|||||.||
Human   316 DTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDV 380

  Fly   327 TTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLK 391
            ..||:|:|::::.. .|:.|.|||||||||||:||||||...:||:.||||.:||:||||..|||
Human   381 NKCEIARFFKLHER-KCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLK 444

  Fly   392 DRVSIVQGGYVSSSVNKSLPAKKAGNILNKPRGD------SASSGATSSSAGGGNFASGNNNEAS 450
            .       ||:... |:.|...|...:.:||..:      |.....|.:
Human   445 H-------GYIPGK-NRDLKVVKKNILDSKPTANKKCDLISIPKKTTDT---------------- 485

  Fly   451 EGGPPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALE 489
                 |:|.:|..|..|..||:.:|..|..|:.||..||
Human   486 -----ASVQNEAKLDEILKEIKSIKDTICNQDERISKLE 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	WD40	9..>392	CDD:475233	237/384 (62%)
		WD40 repeat	37..78	CDD:293791	25/40 (63%)
		WD40 repeat	85..129	CDD:293791	33/43 (77%)
		WD40 repeat	134..171	CDD:293791	24/36 (67%)
		WD40 repeat	178..213	CDD:293791	15/35 (43%)
		WD40 repeat	220..260	CDD:293791	21/39 (54%)
		WD40 repeat	267..308	CDD:293791	28/40 (70%)
CORO1C	NP_001098707.1	WD40	61..>455	CDD:475233	241/402 (60%)
		WD40 repeat	89..131	CDD:293791	26/41 (63%)
		WD40 repeat	137..181	CDD:293791	33/43 (77%)
		WD40 repeat	186..223	CDD:293791	24/36 (67%)
		WD40 repeat	231..266	CDD:293791	15/34 (44%)
		WD40 repeat	274..313	CDD:293791	21/38 (55%)
		WD40 repeat	321..362	CDD:293791	28/40 (70%)