Protein Alignment coro and Coro1a

DIOPT Version :10

• Sequence 1: NP_001260743.1
• Gene: coro / 35596
• FlyBaseID: FBgn0265935
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_034028.1
• Gene: Coro1a / 12721
• MGIID: 1345961
• Length: 461
• Species: Mus musculus
• Alignment Length: 499
• Identity: 251/499 - (50%)
• Similarity: 336/499 - (67%)
• Gaps: 42/499 - (8%)

  Fly     1 MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHN 65
            ||.:||||||||||:||..|.:|||:::|||:::|||.||||||||:|:|.|::|||||:|||..
Mouse     1 MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLG 65

  Fly    66 KVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFH 130
            |.||:..:.|||.||..||||||||||||||||||||||.|.||:||||||...|.|||:.|..|
Mouse    66 KTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGH 130

  Fly   131 QRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHI--DSHPDIVYSACFNWDGSKLVTTC 193
            .:|||:|.|||:|.||||:||.||.:::|:||||..::.:  |.|||.:||..::.||:.:.|:|
Mouse   131 TKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSC 195

  Fly   194 KDKKIRIYDPRTAELESEA-MCHEGSKATRAIFLRHGLIFTTGFNRSSERQYSLRAPDALNEPIV 257
            :||::|:.:||...:.:|. ..|||::...|:|:..|.|.||||:|.||||.:|.....|.||:.
Mouse   196 RDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLS 260

  Fly   258 MVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYINTFQTTEPQRGIGLMPKR 322
            :.|||||:||:.|.:|.|||::||||||||.|||||:|.|.||:||::.|.:.|.|||:|.||||
Mouse   261 LQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKR 325

  Fly   323 GCDVTTCEVAKFYRMNNNGLCQVISMTVPRKSDLFQEDLYPDTLAEDAAITAEEWIDGKDADPIT 387
            |.:|..||:|:||:::.. .|:.|:||||||||||||||||.|...|.|:|||||:.|:||.|:.
Mouse   326 GLEVNKCEIARFYKLHER-KCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLL 389

  Fly   388 FSLKDRVSIVQGGYVSSSVNKSLPAKKAGNILNKPRG-DSASSGATSSSAGGGNFASGNNNEASE 451
            .||||       |||        |.|.....:|  || |||...||..
Mouse   390 ISLKD-------GYV--------PPKSRELRVN--RGLDSARRRATPE----------------- 420

  Fly   452 GGPPAAVLSEKDLRTIQDEIRKLKAIIVKQENRIRALEAKEDAR 495
               |:...|...:..:::::|.|.||:.|.:.|:..||....|:
Mouse   421 ---PSGTPSSDTVSRLEEDVRNLNAIVQKLQERLDRLEETVQAK 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
coro	NP_001260743.1	WD40	9..>392	CDD:475233	219/385 (57%)
		WD40 repeat	37..78	CDD:293791	25/40 (63%)
		WD40 repeat	85..129	CDD:293791	34/43 (79%)
		WD40 repeat	134..171	CDD:293791	20/38 (53%)
		WD40 repeat	178..213	CDD:293791	12/35 (34%)
		WD40 repeat	220..260	CDD:293791	17/39 (44%)
		WD40 repeat	267..308	CDD:293791	25/40 (63%)
Coro1a	NP_034028.1	WD40	9..461	CDD:475233	244/489 (50%)
		WD 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:16407068	13..63		31/49 (63%)
		WD40 repeat	37..79	CDD:293791	26/41 (63%)
		WD 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:16407068	73..110		29/36 (81%)
		WD40 repeat	85..129	CDD:293791	34/43 (79%)
		WD 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:16407068	123..160		20/36 (56%)
		WD40 repeat	134..171	CDD:293791	20/36 (56%)
		WD 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:16407068	164..204		14/39 (36%)
		WD40 repeat	180..215	CDD:293791	12/34 (35%)
		WD 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:16407068	207..251		18/43 (42%)
		WD40 repeat	223..263	CDD:293791	17/39 (44%)
		WD 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:16407068	258..296		24/37 (65%)
		WD40 repeat	270..311	CDD:293791	25/40 (63%)
		WD 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:16407068	302..349		22/47 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..434		10/52 (19%)