DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zip42C.2 and SLC39A10

DIOPT Version :9

Sequence 1:	NP_610231.2	Gene:	Zip42C.2 / 35580	FlyBaseID:	FBgn0033097	Length:	310	Species:	Drosophila melanogaster
Sequence 2:	NP_001120729.1	Gene:	SLC39A10 / 57181	HGNCID:	20861	Length:	831	Species:	Homo sapiens

Alignment Length:	462	Identity:	83/462 - (17%)
Similarity:	139/462 - (30%)	Gaps:	212/462 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VAKIVAIVVLFLVTLI-FCFIPYLLDRFYKWTQRPENNAREFKVVLC-LLNFGGGVLIATTFIHM 70
            :..|::|.|:.|::|: ...:|.:             |...||.:|. |:....|.:.....:|:
Human   408 ICGIISITVISLLSLLGVILVPII-------------NQGCFKFLLTFLVALAVGTMSGDALLHL 459

  Fly    71 LP-------------------------EVVEVVNALQDCRMLAPTPFGLPEVLLCTGFYLMY--- 107
            ||                         :.:|..:|:            |..::...|.||::
Human   460 LPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAV------------LKGLVALGGIYLLFIIE 512

  Fly   108 -CIEETMHFVVRRRQQ--------------RKLRE-----------------------VVTIKDA 134
             ||....|:..:|.:|              |||.:                       ||:....
Human   513 HCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRL 577

  Fly   135 GEELRTEIVVQPEESPK---------------------------------------------EPN 154
            .|...|::..|.|..||                                             ...
Human   578 NETELTDLEGQQESPPKNYLCIEEEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQ 642

  Fly   155 W-----------------LRGLGI-------IVALSLHELFGGMAIGLEMSVSTVWFMTGAISVH 195
            |                 |:..||       |:...:|....|:|||...|..    :||.||..
Human   643 WHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAG----LTGGISTS 703

  Fly   196 KLVLAFC---------------IGMEIMMAHTRWLLAVVYLLVFSIVTPIGVGIGIAVSESAAAN 245
              :..||               .||.:..       |:||.|:.:::..||:.||.||.:.|
Human   704 --IAVFCHELPHELGDFAVLLKAGMTVKQ-------AIVYNLLSAMMAYIGMLIGTAVGQYA--- 756

  Fly   246 QPSTVSGILQGLACGTLIYVVFFEIVA---------KNH----AGIRIL--LSSMVGFVLMFGLQ 295
              :.::..:..:..|..:||...:::.         :.|    .|..||  |..:.||.:|  |.
Human   757 --NNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIM--LV 817

  Fly   296 IAIGEAK 302
            ||:.|.|
Human   818 IALYEDK 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zip42C.2	NP_610231.2	Zip	9..294	CDD:280666	78/451 (17%)
SLC39A10	NP_001120729.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..318
		Zip	404..819	CDD:280666	79/455 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..484		0/19 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910