Protein Alignment chk and Slc16a3

DIOPT Version :9

• Sequence 1: NP_001163063.1
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_110461.1
• Gene: Slc16a3 / 80878
• RGDID: 620603
• Length: 471
• Species: Rattus norvegicus
• Alignment Length: 779
• Identity: 148/779 - (18%)
• Similarity: 248/779 - (31%)
• Gaps: 374/779 - (48%)

  Fly   131 KMPDGGYGWVVVFASLVVSLIADGLSFSF----GLINVELLEYFGESTSKTAWISSLFFSVPLLM 191
            |.||||:||.|:|...:::    |.|::|    .:...||:..||...|.||||||:..::....
  Rat    14 KAPDGGWGWAVLFGCFIIT----GFSYAFPKAVSVFFKELMHEFGIGYSDTAWISSILLAMLYGT 74

  Fly   192 GPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAF 256
            ||:.|..|:::|||.:.::||:.::.|...:|||.||..:.:|.|:|:||||.:.:..:::.:..
  Rat    75 GPLCSMCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQIYLTTGVITGLGLALNFQPSLIMLNR 139

  Fly   257 WFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLI 321
            :|:|:|..|.|:.|:|:.:.....:.|...|.:.|||||..|||||.:||.|||.||||
  Rat   140 YFNKRRPMANGLAAAGSPVFLCALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMR------ 198

  Fly   322 EENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRY 386
                                                                    ||
  Rat   199 --------------------------------------------------------PL------- 200

  Fly   387 RSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDD 451
                                                                             
  Rat   201 ----------------------------------------------------------------- 200

  Fly   452 TLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSS----------DEGYLTQKHAS 506
                 :|.:|                     |.|..|:|..|.|          |.|:|....|:
  Rat   201 -----VAPQA---------------------SGGAEPHGPQRPSPRLLDLSVFRDRGFLIYAVAA 239

  Fly   507 SRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAI 571
            |                    :.|.||....|.::|      |:||                :.:
  Rat   240 S--------------------IMVLGLFVPPVFVVS------YAKD----------------MGV 262

  Fly   572 PEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYR 636
            |:          |:.|.|.:|.|.  :....:|:
  Rat   263 PD----------TKAAFLLTILGF--IDIFARPT------------------------------- 284

  Fly   637 GAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTL 701
                                                ..|:..:|.:..:|::| ..||:|
  Rat   285 ------------------------------------AGFITGLKKVRPYSVYL-FSFAMF----- 307

  Fly   702 FLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINICYSLCML 766
              |..|.                                          ||:
  Rat   308 --FNGFT------------------------------------------DLT------------- 315

  Fly   767 VCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGM 831
              |::.       ::|.||:|.|:.||.::....:....:|::||....|:.|.|||||::.|.:
  Rat   316 --GSTA-------SDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAV 371

  Fly   832 IAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIE-FC--EKKAPKESDSDVLETKKAQL 892
            :.|||..|.:.:.|..:...|..||..:..|.:...|.. ||  ::|.|:.:..:.:.:::.:|
  Rat   372 LIGPPSGGKLLDATKVYKYVFILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTKPEEVASEEEKL 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	63/175 (36%)
		MFS	<685..869	CDD:119392	37/183 (20%)
Slc16a3	NP_110461.1	MFS_MCT3_4	21..410	CDD:340988	138/745 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm12325
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810