Protein Alignment chk and slc16a12

DIOPT Version :9

• Sequence 1: NP_001163063.1
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_989310.1
• Gene: slc16a12 / 394932
• XenbaseID: XB-GENE-1012784
• Length: 473
• Species: Xenopus tropicalis
• Alignment Length: 758
• Identity: 155/758 - (20%)
• Similarity: 237/758 - (31%)
• Gaps: 331/758 - (43%)

  Fly   128 KTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKTAWISSLFFSVPLLMG 192
            |.|  ||||:||::|.....|::....::....:..||...||.:..::||||.|:.....:|..
 Frog    10 KAP--PDGGWGWMIVIGCFFVTVCTRAVTRCISIFFVEFQSYFAQDYARTAWIHSIVDCSTMLCA 72

  Fly   193 PIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIGYVTAVVSIAFW 257
            ||.|.:.:.:.|:...|||||:::.|..||||..|:|.|.:|.|:::|||..:.|..|:..:..:
 Frog    73 PIGSYVSNHFSCQVGIILGGVLASTGLVLSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKY 137

  Fly   258 FDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCGALMRDPDWLIE 322
            |:|::..|.||..||:|||||:.|.:...|||.:.||||.|||||.:.|.||||||||
 Frog   138 FEKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVSNLCVCGALMR------- 195

  Fly   323 ENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQIDDPLDSALKRYR 387
                             .:.|:|               |||......|  |..::|..|.
 Frog   196 -----------------PITLKE---------------DSLHYPLKQE--QMENEPTQSG----- 221

  Fly   388 SEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDT 452
                        .|||.|
 Frog   222 ------------RLDSSC----------------------------------------------- 227

  Fly   453 LMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHASSRYSLNENIFM 517
                                    ||                     |.|..:..|.
 Frog   228 ------------------------SP---------------------LCQDCSHKRL-------- 239

  Fly   518 AKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAIPEQEQSVNSEL 582
                                         ||.:|.|...||:|
 Frog   240 -----------------------------CYCTKKEYSFLLKP---------------------- 253

  Fly   583 ATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRL 647
                                                                             
 Frog   254 ----------------------------------------------------------------- 253

  Fly   648 RASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYL 712
                                                        ||.:..:|.|||......|::
 Frog   254 --------------------------------------------KFMVLAVSFLFLAYGCSPPFV 274

  Fly   713 YLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNIN--ICYSLCMLVCGASVFFM 775
            ||..|.........::|.|:|.:||...||.|..|::.|..::..:  .||.:.:.:.|....|:
 Frog   275 YLVPYALNVGVSNQEAAFLMSILGIIDIVGNITFGWVTDTRFLKKHRYCCYLIAVGLDGLCCLFL 339

  Fly   776 PLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGV 840
            |:| |.:..|:...|:||:...:..:..|.:...:|.....:.|.|:|..:..|..:..|||||.
 Frog   340 PIL-TRFQLLVPFSVMFGYFDGAYVALIPVVTGDVVGTSSLSSALGVVFFLHAVPYLVSPPIAGW 403

  Fly   841 IYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCE-----KKAPK 878
            :.:.||.:...|..:|..:..   |:.|:...:     ||.||
 Frog   404 LVDTTGDYTAAFLLSGFSMIF---CAVLLALAKIINRIKKRPK 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	67/171 (39%)
		MFS	<685..869	CDD:119392	47/185 (25%)
slc16a12	NP_989310.1	2A0111	12..444	CDD:331689	154/756 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	93	1.000	Domainoid score	I7419
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm14090
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910