DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and CG8468

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_610940.1	Gene:	CG8468 / 36577	FlyBaseID:	FBgn0033913	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	191/799 - (23%)
Similarity:	308/799 - (38%)	Gaps:	192/799 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 GQVKRRKRLI--SNESGDSIDSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVE 165
            |.|.::...|  .||..:.|:.::.  ..|  ||.|:.|||:.||.:...:.||:.|..|||..:
  Fly    16 GLVSKQPENIKEENEGEEEIEEAAV--VVP--PDSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQ 76

  Fly   166 LLEYFGESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEM 230
            |:..||.|.:..|::|||.....|:.||..|.:.:::|.|.:||.|.:.:|..|.||.|..|:|.
  Fly    77 LMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEY 141

  Fly   231 LMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRG 295
            |.:.:|::.|:|..:.|:.|||.|.|:|:|.|..|||:...|:|:||||:|.||..|::| |||
  Fly   142 LFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKS-GWR- 204

  Fly   296 ATLILGGTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVL 360
            .||.:.|.::.:|....|...|        ::..:.|||   |.....:|.|||
  Fly   205 YTLAIQGIIVLSCALFGLAFRP--------IQPITLSVT---NEEGDEQEKKKL----------- 247

  Fly   361 DSLVTKNNTEANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPS 425
                   |...|                     |...|.:|......|.|       .||..|.|
  Fly   248 -------NGHGN---------------------TVAPTPQLHQAAFTKPL-------PEGRFAYS 277

  Fly   426 RENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNG 490
            ..|                   |..:|.||.........|::.:          :..:..|.|:|
  Fly   278 MPN-------------------SAHNTYMGASQRNHYPTAQEIF----------KGMNLERRPSG 313

  Fly   491 SLRSSDEGYLTQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETF 555
            :.:.|....|.|...|            :.|||:....::....|..:..:.|:
  Fly   314 TAQGSKGTELKQLRKS------------QPTTPNGDPQQLTFNLHKELTTVGEN----------- 355

  Fly   556 ALLEPSRRIRPTVIAIPEQEQSVNSEL-------ATRRARLDSITGIR------RLSRSKKPSHH 607
                              :|::.|..|       .|.:||..:::|.|      |.:.:...:||
  Fly   356 ------------------EEEAENDNLLETEAKPVTIQARRHTVSGRRPQDIGKRSAAAAHEAHH 402

  Fly   608 RSNLRRNISIRNSNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWY 672
                       ..:......::|:.|.:.|::....:|:.:.|..   |..|:|.:..::
  Fly   403 -----------GQSHSSSRPMYRDDIFFSGSLTRIPQYQSQTSLA---YHMSVTRLPTKQ----- 448

  Fly   673 DNFVD--------------TMKSIFDFSLFLDMKFALFNLSTLFLFIWFIIPYLYLPDYMKQYKY 723
            |...|              |:.::.|.:|.....|.....|.....:.|.:|:.:|.|..|....
  Fly   449 DMLEDRQKGCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGFFVPFTFLVDRAKAAGM 513

  Fly   724 DVSQSAELISDVGIAQTVGMIGLGYLGDLS-----WMNINICYSLCMLVCGASVFFMPLLITNYM 783
            |...:..::|.:|:..|...|..|.|....     |:| |..     |..|........::.|..
  Fly   514 DEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLN-NFA-----LTAGGIATICSGIVINTA 572

  Fly   784 GLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRW 848
            ......:.||...|...:....|.|.::.|:..|.|||.::|.||:....|.||||.:|..||.:
  Fly   573 TQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSY 637

  Fly   849 DDTFYYAGIFIALSGVCSY 867
            :..||:||..|.||....|
  Fly   638 NAAFYFAGGLILLSAFLCY 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	67/171 (39%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	50/188 (27%)
CG8468	NP_610940.1	MFS	50..>227	CDD:119392	71/186 (38%)
CG8468	NP_610940.1	MFS	<481..658	CDD:119392	49/182 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I559
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2778
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	7	6.960