Protein Alignment chk and slc16a3b

DIOPT Version :10

• Sequence 1: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_997873.1
• Gene: slc16a3b / 327276
• ZFINID: ZDB-GENE-030131-5487
• Length: 508
• Species: Danio rerio
• Alignment Length: 793
• Identity: 143/793 - (18%)
• Similarity: 242/793 - (30%)
• Gaps: 374/793 - (47%)

  Fly   115 ESGDSIDSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSF----GLINVELLEYFGESTS 175
            ::|||         ..|.||||:||.|:|...:::    |.|::|    .:...||:..||...|
Zfish     7 DTGDS---------GVKAPDGGWGWAVLFGCFIIT----GFSYAFPKAVSVFFKELIREFGVGYS 58

  Fly   176 KTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISG 240
            .||||||:..::....||:.|.||:::|||.:.::||:.::.|..|:||..:|..:.:..|:|:|
Zfish    59 DTAWISSILLAMLYGTGPLCSILVNRFGCRPVMMVGGLFASLGMVLASFATNIIHIYLCTGVITG 123

  Fly   241 LGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTML 305
            |||.:.:..:::.:..:|.:||..|.|:.|:|:.:.....:.|...|...|||||..|||||.:|
Zfish   124 LGLALNFQPSLIMLNRYFSEKRPLANGLAAAGSPVALCCLSPLGQVLQYKYGWRGGFLILGGLLL 188

  Fly   306 NACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTE 370
            |.|.||||||
Zfish   189 NCCACGALMR------------------------------------------------------- 198

  Fly   371 ANQQIDDPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSG 435
                   ||.:..|             |.|:                   ||.|
Zfish   199 -------PLLAPKK-------------TSEV-------------------EEKP----------- 213

  Fly   436 AGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYL 500
                                                                             
Zfish   214 ----------------------------------------------------------------- 213

  Fly   501 TQKHASSRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIR 565
                              |.|.|
Zfish   214 ------------------KETKP------------------------------------------ 218

  Fly   566 PTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHR 630
                                                 ||
Zfish   219 -------------------------------------KP-------------------------- 220

  Fly   631 NSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFAL 695
                                                              .:.||::|.|..|.:
Zfish   221 --------------------------------------------------KLLDFTVFKDRGFLI 235

  Fly   696 FNLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYLGDLSWMNINIC 760
            :.::...:.:...:|.:::..|.|:...:.::||.|::.:|..........|.:..|.|:.....
Zfish   236 YTIAASIMVLGLFVPPVFVVSYAKELGNEDTKSALLLTILGFIDIFARPTSGIIAGLKWVRPRCV 300

  Fly   761 Y--SLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTCAYGLV 823
            |  |..|:..|.: ..:.....:|..|:|.|:.||.::....:....:|::||..:.|:.|.|||
Zfish   301 YLFSFAMIFNGIA-DILGSFAKDYASLVVFCIFFGISYGMVGALQFEVLMAIVGTEKFSSAIGLV 364

  Fly   824 LLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALS----GVCSYLIEFCEKK-----APKE 879
            |||:.:.::.|||.||.:.:.|..:...|..||..:.||    .:|:.|  |.::|     .|.:
Zfish   365 LLVEAIAVLVGPPGAGRLLDATKNYMYVFMLAGCEVVLSALVLAICNLL--FIKRKPQQPDPPAK 427

  Fly   880 SDSDVLETKKAQL 892
            .:..:.||:..:|
Zfish   428 MEMAITETEMEEL 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	65/180 (36%)
		MFS	<687..869	CDD:475125	46/187 (25%)
slc16a3b	NP_997873.1	MFS_MCT3_4	21..411	CDD:340988	127/737 (17%)