DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chk and AgaP_AGAP005394

DIOPT Version :9

Sequence 1:	NP_001163063.1	Gene:	chk / 35578	FlyBaseID:	FBgn0033095	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_315403.4	Gene:	AgaP_AGAP005394 / 1276095	VectorBaseID:	AGAP005394	Length:	904	Species:	Anopheles gambiae

Alignment Length:	914	Identity:	442/914 - (48%)
Similarity:	564/914 - (61%)	Gaps:	154/914 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 KAIKHDLF--PEVTFCNLSVEELA-----DGAGHSRVVRSSVIEL----------EDGTMTCLMN 100
            :|||.:|.  .||||..:...:|.     .|.|.:.....|:.:|          :||.    .|
Mosquito    47 EAIKTNLLNTNEVTFSTVLDTDLGPPGSPPGRGGNYGKNLSMAQLKVPGVGGEPADDGG----GN 107

  Fly   101 GNGQVKRRKRLISNES-GDSIDSSSTE----KKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFG 160
            |.|...||.||||..| .|||.||..|    ||.||:||||||||:||:|.::|||.||:|||||
Mosquito   108 GGGDGTRRIRLISELSEADSILSSYHEGGYKKKPPKIPDGGYGWVIVFSSFMISLIMDGVSFSFG 172

  Fly   161 LINVELLEYFGESTSKTAWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFC 225
            ||..|||:|||||.||||||.|||.:||||.|||.|||||:|||||||:|||.:...||.|:|.|
Mosquito   173 LIYTELLDYFGESKSKTAWIGSLFIAVPLLSGPIMSNLVDRYGCRKMTMLGGFIGGMGFVLASIC 237

  Fly   226 NSIEMLMVTFGIISGLGLGIGYVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIES 290
            .|:|.|..||||:||:|||.||||.||.:||||||:||||||||||||||||||||.||.:||.:
Mosquito   238 QSVEQLYFTFGILSGVGLGFGYVTVVVCVAFWFDKRRTFATGIGASGTGIGTFVYAPLTQWLINN 302

  Fly   291 YGWRGATLILGGTMLNACVCGALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGIT 355
            :||||.||||.||:.|....|||||||:|:|||:|||||:||:.|||||||.|:|||||::|||.
Mosquito   303 FGWRGTTLILAGTLFNMVAMGALMRDPEWMIEESRLESRAQSIQTFSNSSVYLDEIKKLIETGIP 367

  Fly   356 KEAVLDSLVTKNNTEANQQIDDPLDSAL-KRYRSEIFLPTFLSTQE---------------LDSI 404
            ||.|||:|||..||||||.| .|.|.|: |:|.||:.||||.|.||               |.:
Mosquito   368 KEHVLDTLVTNVNTEANQAI-PPEDPAMTKKYSSEVALPTFFSEQEQHGAGGGGPRAGGGNLHA- 430

  Fly   405 CEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPPSTAVIGSPDDTLMGGIAHEAAEEAKKAY 469
                  |.|||||          |:|:..:...:                |.:|.      .||.
Mosquito   431 ------SHRSLRH----------NVLTKETFKRS----------------GRLAQ------AKAR 457

  Fly   470 LASIETLSPSEKRSTGRT----PNG------------SLRSSDEGYLTQKHA--------SSRYS 510
            |||.|||:..||.|....    |:|            |:.|.::|||::|.|        .|.:|
Mosquito   458 LASTETLNSYEKLSDEEEHEHHPDGVSLGIHASLKTLSVASLEDGYLSEKRAQELHVKAGGSTWS 522

  Fly   511 LNENIFMAKHTTPS---------------------ISNLKVNGLRHNSVDILSEDMHCYYSKDET 554
            |:|.........||                     ....|....|.||:|::.|:
Mosquito   523 LDEVALAGSLVVPSPHGDAASGGGVGGGGASIGDGSRTEKCRSFRGNSLDVVYEN---------- 577

  Fly   555 FALLEPSRRIRPTVIAIPEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRN 619
             .:..|:.....|:: :|:|.:.::......|.     .|:::          :::|.|..|:|.
Mosquito   578 -EIFNPNVDTNVTLV-VPKQTKWLHQRAVAPRG-----GGLKK----------QTSLGRQHSMRY 625

  Fly   620 SNFLKDMRIHRNSIHYRGAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFD 684
            |||.||||:||||||||||:||||||||:||||||||||||||||||:::.||.:|:||:|||||
Mosquito   626 SNFYKDMRLHRNSIHYRGALLNTHRYRLKASSCPNIYRNSMTTIAKEQDEPWYGSFIDTLKSIFD 690

  Fly   685 FSLFLDMKFALFNLSTLFLFIWFIIPYLYLPDYMKQYKYDVSQSAELISDVGIAQTVGMIGLGYL 749
            ||||.:.:|.:.::|||.||:|:||||.|:|:|:..|||.....|.|||.:||..|:||:|||:|
Mosquito   691 FSLFFEFRFGMLSISTLLLFVWYIIPYFYIPEYVLNYKYSEQDGANLISLIGITNTIGMVGLGWL 755

  Fly   750 GDLSWMNINICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLD 814
            ||..|:::...|.:|:..||||:|.||.||.:|..::|:|:||||||||:|||||.|:|.:|.||
Mosquito   756 GDQPWVDVGKTYGVCLAFCGASIFVMPWLIWSYPAMVVLCIIFGFTFASTFSFTPIIMVRLVSLD 820

  Fly   815 DFTCAYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGVCSYLIEFCEKKAPKE 879
            |||.||||||||||:|.:.||||||.:|:.|.||||:||.||.||.|||||::||...|:.|..|
Mosquito   821 DFTVAYGLVLLVQGIGSLIGPPIAGFLYDVTNRWDDSFYAAGFFIFLSGVCAWLIGSLEQTADNE 885

  Fly   880 SDSD 883
            .:.|
Mosquito   886 EEQD 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_001163063.1	MFS	143..>315	CDD:119392	120/171 (70%)
chk	NP_001163063.1	MFS	<685..869	CDD:119392	106/183 (58%)
AgaP_AGAP005394	XP_315403.4	MFS	151..>327	CDD:119392	123/175 (70%)
AgaP_AGAP005394	XP_315403.4	MFS	<691..875	CDD:119392	106/183 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	266	1.000	Domainoid score	I4465
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74834
Inparanoid	1	1.050	763	1.000	Inparanoid score	I1572
OMA	1	1.010	-	-		QHG29130
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		oto108199
Panther	1	1.100	-	-	LDO	PTHR11360
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.930