Protein Alignment chk and slc16a7

DIOPT Version :10

• Sequence 1: NP_610230.3
• Gene: chk / 35578
• FlyBaseID: FBgn0033095
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001106392.1
• Gene: slc16a7 / 100127205
• XenbaseID: XB-GENE-1008526
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 796
• Identity: 158/796 - (19%)
• Similarity: 235/796 - (29%)
• Gaps: 379/796 - (47%)

  Fly   121 DSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSF-GLINV---ELLEYFGESTSKTAWIS 181
            |...|.:.||  ||||:||||||.    |.|:.|.|::| ..|.|   |:.|.|..|.|:.||||
 Frog     3 DIPVTLQYTP--PDGGWGWVVVFG----SFISIGFSYAFPKAITVFFKEIQEIFNTSYSEIAWIS 61

  Fly   182 SLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVTFGIISGLGLGIG 246
            |:..:|....|||.|.||:|||.|.:.|.|||:.:.....:|||||:..|.:..|::.|.||...
 Frog    62 SIMLAVMYAGGPISSILVNKYGSRPVVIGGGVLCSLAMISASFCNSVMQLYICIGVMGGFGLAFN 126

  Fly   247 YVTAVVSIAFWFDKKRTFATGIGASGTGIGTFVYARLTSYLIESYGWRGATLILGGTMLNACVCG 311
            ...::..|..:|.|||..|.|:..:|:.:.....|.|..:|...:||||:.|||||.:||.||.|
 Frog   127 LQPSLTIIGKYFFKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFLILGGLLLNCCVAG 191

  Fly   312 ALMRDPDWLIEENRLESRSQSVTTFSNSSVCLEEIKKLLDTGITKEAVLDSLVTKNNTEANQQID 376
            :|||
 Frog   192 SLMR------------------------------------------------------------- 195

  Fly   377 DPLDSALKRYRSEIFLPTFLSTQELDSICEVKSLSRRSLRHKEGEEAPSRENLLSMSSGAGAYPP 441
             |:...                       .||         |:.|:||.
 Frog   196 -PIGPK-----------------------PVK---------KDIEKAPK---------------- 211

  Fly   442 STAVIGSPDDTLMGGIAHEAAEEAKKAYLASIETLSPSEKRSTGRTPNGSLRSSDEGYLTQKHAS 506
                    ||
 Frog   212 --------DD------------------------------------------------------- 213

  Fly   507 SRYSLNENIFMAKHTTPSISNLKVNGLRHNSVDILSEDMHCYYSKDETFALLEPSRRIRPTVIAI 571
                  ||                                  :.|.|:..
 Frog   214 ------EN----------------------------------HKKKESVC--------------- 223

  Fly   572 PEQEQSVNSELATRRARLDSITGIRRLSRSKKPSHHRSNLRRNISIRNSNFLKDMRIHRNSIHYR 636
                ||:|..|
 Frog   224 ----QSINKYL------------------------------------------------------ 230

  Fly   637 GAMLNTHRYRLRASSCPNIYRNSMTTIAKEEEDTWYDNFVDTMKSIFDFSLFLDMKFALFNLSTL 701
                                                           |.|||....|.::....:
 Frog   231 -----------------------------------------------DLSLFKHRGFLIYLSGNV 248

  Fly   702 FLFIWFIIPYLYLPDYMKQYKYDVSQSAELIS-----DVGIAQTVGMIG--------LGYLGDLS 753
            .:||.|..|.::|..|.|....|...||.|:|     |:....|:||:.        :.|....:
 Frog   249 IMFIGFFAPIVFLAPYAKHMGIDQYSSAFLLSILAFVDMVARPTMGMVANTRFIRPRIQYFFSFA 313

  Fly   754 WMNINICYSLCMLVCGASVFFMPLLITNYMGLMVMCVIFGFTFASSFSFTPSILVSIVDLDDFTC 818
            .:...:|:.||.|.            .:|.||::..|.|||.|....|.....|:.||....|:.
 Frog   314 ILYNGVCHLLCPLA------------NDYTGLVIYAVFFGFAFGMVSSVLFETLMDIVGAARFSS 366

  Fly   819 AYGLVLLVQGVGMIAGPPIAGVIYEYTGRWDDTFYYAGIFIALSGV-------CSYLIEFCEKKA 876
            |.||..:|:...::.|||:.|.:.:.||.:...::..|:.:.::.:       .:|.:...||.|
 Frog   367 AVGLTTIVECCPVLIGPPLGGFLVDVTGNYKYMYFVCGVIVIIASIWLFIGNAINYRMLAKEKMA 431

  Fly   877 PK----ESDSDVLETK 888
            ..    :..:|:.||:
 Frog   432 TSAKNIDEKTDLKETE 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chk	NP_610230.3	MFS_MCT_SLC16	138..>315	CDD:340910	74/180 (41%)
		MFS	<687..869	CDD:475125	49/201 (24%)
slc16a7	NP_001106392.1	2A0113	10..447	CDD:273325	155/787 (20%)