Protein Alignment Rab2 and RAB4A

DIOPT Version :10

• Sequence 1: NP_477090.1
• Gene: Rab2 / 35577
• FlyBaseID: FBgn0014009
• Length: 213
• Species: Drosophila melanogaster
• Sequence 2: NP_004569.2
• Gene: RAB4A / 5867
• HGNCID: 9781
• Length: 218
• Species: Homo sapiens
• Alignment Length: 216
• Identity: 116/216 - (53%)
• Similarity: 148/216 - (68%)
• Gaps: 11/216 - (5%)

  Fly     2 SYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQE 66
            :|.:|||:::||:.|.||||||.||.:|:|:...:.|||||||:::|.:.||.:|||||||||||
Human     9 TYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQE 73

  Fly    67 AFRSITRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSNMVIMLIGNKSDLDSRREVKK 131
            .|||:||||||||||||||||||.|||:|.||.||.|||..::.|:||:|.|||.|||:.|||..
Human    74 RFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTF 138

  Fly   132 EEGEAFAREHGLVFMETSARTAANVEEAFINTAKEIYEKIQEGVFDINNEANGIKIG-----QQH 191
            .|...||:|:.|:|:||||.|..||||||:..|::|..||:.|..|.....:||:.|     |..
Human   139 LEASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALRQLR 203

  Fly   192 SPTNPSLPGAGGAAGAANSGC 212
            ||.....|      .|...||
Human   204 SPRRAQAP------NAQECGC 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab2	NP_477090.1	PLN03108	1..213	CDD:178655	116/216 (54%)
RAB4A	NP_004569.2	Rab4	14..174	CDD:206696	99/159 (62%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	44..49		3/4 (75%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	70..79		7/8 (88%)