Protein Alignment Pld and PGS1

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: XP_011523789.1
• Gene: PGS1 / 9489
• HGNCID: 30029
• Length: 646
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 101/525 - (19%)
• Similarity: 167/525 - (31%)
• Gaps: 202/525 - (38%)

  Fly   206 EIPFTSIYGPSVKFNSFQRKVFIPGREIHVRIVDTERS---VTTHLLNPNLYTIELTHGP----- 262
            |..:..:..|..:....||.:|:             ||   :...||:|.:  .::|..|
Human   115 EAVYIMVSAPGCECRRVQRGLFL-------------RSPWLLLAPLLSPAV--PQVTSPPCCLCP 164

  Fly   263 -----FKWTIKRRYKHF--NSLHQQL-----SFFRTSLNIPFPSRSHKEKRTTLKAT-------- 307
                 |:| |:.....|  :|.|.::     .||..     ...:....||..:.|:
Human   165 EGVHRFQW-IRNLVPEFGVSSSHVRVLSSPAEFFEL-----MKGQIRVAKRRVVMASLYLGTGPL 223

  Fly   308 AREMAD--ESTLK-----DLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPNHSSILAGL 365
            .:|:.|  ||||:     ..||:.||                                 |||...
Human   224 EQELVDCLESTLEKSLQAKFPSNLKV---------------------------------SILLDF 255

  Fly   366 TPRRIQKKRKKKKKRKLP---RFPNRPESLVTVENLSVRIKQLE-DYLYNLLNISLYRSHHETLN 426
            |  |..:.||..:...||   |||.:           ||:.... .:|..||.:.:....:||:.
Human   256 T--RGSRGRKNSRTMLLPLLRRFPEQ-----------VRVSLFHTPHLRGLLRLLIPERFNETIG 307

  Fly   427 FVEVSNVSFVPGMGIKGKEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCNYFCSDVVCGTWRNR 491
            ...:....|        ...|||          :|.|.                ||......::|
Human   308 LQHIKVYLF--------DNSVIL----------SGANL----------------SDSYFTNRQDR 338

  Fly   492 WFFVKETC--FGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTRRKC 554
            :.|:::..  ..:......::..|.|..||.|.            :||:....| ..|......|
Human   339 YVFLQDCAEIADFFTELVDAVGDVSLQLQGDDT------------VQVVDGMVH-PYKGDRAEYC 390

  Fly   555 KEWMQYLKNTANS--------YARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAAL 611
            |...:.:.:..||        :|:.|            .:|:..|      |..:|.|.....|
Human   391 KAANKRVMDVINSARTRQQMLHAQTF------------HSNSLLT------QEDAAAAGDRRPA- 436

  Fly   612 EEIYIADWWLSPEIYMKRPALDGDYWRLDKI----LLRKAEQGVRVFV------LLYKEVEMALG 666
                 .|.|:.|.|.||...:     ::|:|    ||.:||:|.:|::      |....:::.||
Human   437 -----PDTWIYPLIQMKPFEI-----QIDEIVTETLLTEAERGAKVYLTTGYFNLTQAYMDLVLG 491

  Fly   667 INSYY 671
            ..:.|
Human   492 TRAEY 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	47/239 (20%)
		PLN02866	388..1349	CDD:215467	56/305 (18%)
PGS1	XP_011523789.1	PLDc_PGS1_euk_1	186..359	CDD:197233	45/257 (18%)
		PLDc_PGS1_euk_2	439..598	CDD:197235	17/63 (27%)