Protein Alignment Pld and PLD2

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: NP_002654.3
• Gene: PLD2 / 5338
• HGNCID: 9068
• Length: 933
• Species: Homo sapiens
• Alignment Length: 1212
• Identity: 456/1212 - (37%)
• Similarity: 609/1212 - (50%)
• Gaps: 291/1212 - (24%)

  Fly   163 AFPDSVTILSNVGDK----PVLVERKETDDDEEEFDDEENNSVVLRHEIPFTSIYG-PSVKFNSF 222
            |.|:|   |...||:    .:.:|..|.|..:|..|..:.     .|  ||.:||. .|:|.:..
Human     3 ATPES---LFPTGDELDSSQLQMESDEVDTLKEGEDPADR-----MH--PFLAIYELQSLKVHPL 57

  Fly   223 QRKVFIPGREIHVRIVDTERSVTTHLLNP-NLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRT 286
               ||.||..:..::|.|||..:...:.. .||::.||||.|.||.|::|:||..||
Human    58 ---VFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELH-------- 111

  Fly   287 SLNIPFPSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAM 351
                                           :||..| ||..:..||             |..|:
Human   112 -------------------------------RDLLRH-KVLMSLLPL-------------ARFAV 131

  Fly   352 AMISPNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNR-PESLVTVENLSVRIKQLEDYLYNLLNI 415
            | .||...   ||              .|::|..|.. ||.  :..:.:.:.|.||:||..||.:
Human   132 A-YSPARD---AG--------------NREMPSLPRAGPEG--STRHAASKQKYLENYLNRLLTM 176

  Fly   416 SLYRSHHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQAGCNFFGCFQKNCCVRCNYF 479
            |.||::|....|:|||.:||:|.:|.||.||:|.||:|..| ||           ..||.|
Human   177 SFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPG-----------LTCCGR---- 226

  Fly   480 CSDVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHI 544
              |.||..|..||..||::...|:....|:|..|.|||.||:|..|...|..|.|:::.|::|.:
Human   227 --DQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSL 289

  Fly   545 VLKCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEA 609
            :|||.:.|:.:.|.|.:...|....|||...:.|.|:||.|..|.|.|:|:||.|.:||||.:..
Human   290 ILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILR 354

  Fly   610 ALEEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKS 674
            |.|||:|.|||||||:|:|||| ..|.||||.:|.||||:||||.:||:||||:||||||.|||.
Human   355 AQEEIFITDWWLSPEVYLKRPA-HSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKR 418

  Fly   675 TL-AKHENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSIS 738
            .| ..|.|||||||||.    :.|||||||::|:||..||:||:||.||||||.|:||||||..|
Human   419 ALMLLHPNIKVMRHPDQ----VTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSS 479

  Fly   739 TSSFSGSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGD 803
                                                 .||..:||:|.||.|.|
Human   480 -------------------------------------ESAASQPPTPRPDSPAT----------- 496

  Fly   804 RLLIPSTLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATET 868
                                                                 .|..|
Human   497 -----------------------------------------------------PDLSH------- 501

  Fly   869 EEKSAEVYTIESEEATDHEVNLNMASGGQEVAITTSSTQILSEFCGQAKYWFGKDYSNFILKDWM 933
                                                     ::|     :|.||||||.|.|||:
Human   502 -----------------------------------------NQF-----FWLGKDYSNLITKDWV 520

  Fly   934 NLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRDNT-RFPYLMPKS 997
            .|:.||.|.|||.|||||||.|||:.|.|..|||:|||||||||..|..|.:..| .:|||:|||
Human   521 QLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKS 585

  Fly   998 YHQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITKAQHYVYIENQFF 1062
            .......| ......|..|.|:||||..||.|     .:|.||.:||:.||.::||::|||||||
Human   586 TSTANQLP-FTLPGGQCTTVQVLRSVDRWSAG-----TLENSILNAYLHTIRESQHFLYIENQFF 644

  Fly  1063 ITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAI 1127
            |:...|       ..|.|::|:.:..||::|||:...:||||::|||||||||:....|.:::||
Human   645 ISCSDG-------RTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAI 702

  Fly  1128 THWNYASISRGRTSILTRLQEAGIANPENYISFHSLRNHSFLNNTPITELIYVHSKLLIADDRVV 1192
            .|:.|.::.||..|||.||:.|......:|||...||.|..|...|::||||:|||:||||||.|
Human   703 LHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTV 767

  Fly  1193 ICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGRLRKYLFKEHLGLLESEGS 1257
            |.|||||||||::||||||:|.::.|.|.|...|||.:|.:|.||..|||:.|...||     .:
Human   768 IIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILG-----AN 827

  Fly  1258 SRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDL 1322
            :|.|||:.||:|:.|:. .|:.::..|..||:::|:|:|::..::..:||:|....|||..:|.|
Human   828 TRPDLDLRDPICDDFFQ-LWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPL 891

  Fly  1323 AANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVWT 1364
            |.:....:||:||..||:||..|.|.||..||||:||..|||
Human   892 ARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	52/202 (26%)
		PLN02866	388..1349	CDD:215467	387/964 (40%)
PLD2	NP_002654.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		10/33 (30%)
		PLN02866	66..918	CDD:215467	423/1119 (38%)
		Catalytic	441..788		191/513 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..497		10/120 (8%)