Protein Alignment Pld and PLD1

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: NP_002653.1
• Gene: PLD1 / 5337
• HGNCID: 9067
• Length: 1074
• Species: Homo sapiens
• Alignment Length: 1247
• Identity: 452/1247 - (36%)
• Similarity: 645/1247 - (51%)
• Gaps: 240/1247 - (19%)

  Fly   166 DSVTILSNVGDKPVLVERKETDDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFIPG 230
            |...|:.|:..:.:..|.:|.|     :|...::..:....|||::||. :..|.....:.::.|
Human    20 DMSNIIENLDTRELHFEGEEVD-----YDVSPSDPKIQEVYIPFSAIYN-TQGFKEPNIQTYLSG 78

  Fly   231 REIHVRIVDTER-SVTTHLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLNIPFPS 294
            ..|..::::.|| :.||.:.:.||||||||||.|||.:||::|||...|::|..::..:.||.|:
Human    79 CPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPT 143

  Fly   295 RSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPNHS 359
            |.|..:|..::...|||
Human   144 RRHTFRRQNVREEPREM------------------------------------------------ 160

  Fly   360 SILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHHET 424
                                   |..|...|:::..|....|.|||||||..:|.:.:||::|.|
Human   161 -----------------------PSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHAT 202

  Fly   425 LNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQAGCNFFGCFQKNCCVRCNYFCSDVVCGTW 488
            ..|:::|.:||:..:|.||.||:|:||:|..| ||           .|||.:..      .|..|
Human   203 TEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPG-----------LNCCGQGR------ACYRW 250

  Fly   489 RNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTRRK 553
            ..||..||::...|::|..|:|..|:|.|:.|.:..|..:|..:.|:::...:|.::|||.:.|.
Human   251 SKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRH 315

  Fly   554 CKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYIAD 618
            .:.|...::.....:..:|...:...|:|.::.|..|.|||:...|...||:.:|.|.|||:|.|
Human   316 ARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITD 380

  Fly   619 WWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTLAK-HENI 682
            |||||||::|||.::|:.||||.||.|||:||||:|::||||||:||||||.|:|.||.: |.||
Human   381 WWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNI 445

  Fly   683 KVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSISTSSFSGSTR 747
            ||||||||....:.|||||||:|:|||:.||:|||||.||||||:.|||||:||:...: ||
Human   446 KVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVT-SG--- 506

  Fly   748 RTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIPSTLV 812
              |||
Human   507 --PSL------------------------------------------------------------ 509

  Fly   813 SSPGETPAESGIALEGMKL---NTPEME---RKNVLDRLKNNAMKGARMGKDF--------MHRL 863
               |..|..:..::|.::|   |.|...   :|::.|  .::.:||....:.|        :||.
Human   510 ---GSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDD--VDSKLKGIGKPRKFSKFSLYKQLHRH 569

  Fly   864 TATETEEKSAEVYTIESEEATDHEVN-----------------LNMASGGQEVAIT-----TSST 906
            ...:.:       :|.|.::|....|                 |...|...|..:|     |.|.
Human   570 HLHDAD-------SISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADTGSI 627

  Fly   907 QIL----SEFCGQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARD 967
            :.|    .|..|:.::|.||||.||:.|||:.|:.||.|.|||.:||||||||:...|.|.:|||
Human   628 RSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARD 692

  Fly   968 VARHFIQRWNAMKLEKLR-DNTRFPYLMPKSY---HQVRLNPNIQQNRQQRVTCQLLRSVSAWSC 1028
            ||||||||||..|:.|.: .:..:|:|:|||.   |::|    .|.........|||||.:.||.
Human   693 VARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELR----YQVPGSVHANVQLLRSAADWSA 753

  Fly  1029 GFIEADLVEQSIHDAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRA 1093
            |.   ...|:|||.||:..|..::||:||||||||:.       .....|.|:||:.:.:||::|
Human   754 GI---KYHEESIHAAYVHVIENSRHYIYIENQFFISC-------ADDKVVFNKIGDAIAQRILKA 808

  Fly  1094 HKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANP-ENY 1157
            |:|.:.:||||::|||||||||:....|.|::||.|:||.::.||..|||.:| :|.:.|. .||
Human   809 HRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQL-KAELGNQWINY 872

  Fly  1158 ISFHSLRNHSFLNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFE 1222
            |||..||.|:.|....:|||||||||||||||..||.||||||||||:||||||:|.|:.|.|..
Human   873 ISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETV 937

  Fly  1223 DGRMNGKKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEI 1287
            ...|:||:|.:|.||..||...|:..||.|:....     ||.|||.:||:...|...:.:|..|
Human   938 PSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSE-----DIQDPVSDKFFKEVWVSTAARNATI 997

  Fly  1288 YDEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGT 1352
            ||:||:|:|.|.|.....||.:..:|.|||..|..|......|:|:||..|..||::|.|.|...
Human   998 YDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVG 1062

  Fly  1353 SKEGLIPTSVWT 1364
            :||.::|..|||
Human  1063 TKEAIVPMEVWT 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	53/201 (26%)
		PLN02866	388..1349	CDD:215467	395/1007 (39%)
PLD1	NP_002653.1	PLN02866	82..1059	CDD:215467	430/1162 (37%)
		Catalytic	463..928		213/557 (38%)