Protein Alignment Pld and Pld2

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: NP_001289404.1
• Gene: Pld2 / 18806
• MGIID: 892877
• Length: 944
• Species: Mus musculus
• Alignment Length: 1177
• Identity: 437/1177 - (37%)
• Similarity: 587/1177 - (49%)
• Gaps: 294/1177 - (24%)

  Fly   208 PFTSIYG-PSVKFNSFQRKVFIPGREIHVRIVDTERSVTTHLLNP-NLYTIELTHGPFKWTIKRR 270
            |:.:||. ..:|.:..   ||.||..:..::|.|||..:...:.. .||::.||||.|.||.|::
Mouse    42 PYLAIYDLQPLKAHPL---VFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKK 103

  Fly   271 YKHFNSLHQQLSFFRTSLNIPFPSRSHKEKRTTLK----ATAREMADESTLKDLPSHTKVKQTST 331
            ::||..||:.|             :.||...:.|.    |.....|.|:..:|:||
Mouse   104 FRHFQELHRDL-------------QRHKVLMSLLPLARFAVTHSPAREAAAEDIPS--------- 146

  Fly   332 PLRAEGRSSKIAGSNANNAMAMISPNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVE 396
                                                              |||..:...:..|..
Mouse   147 --------------------------------------------------LPRGGSEGSARHTAS 161

  Fly   397 NLSVRIKQLEDYLYNLLNISLYRSHHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQA 460
                :.|.||:||..||.:|.||::|....|:|||.:||:|.:|.||.||||.||:|..| ||..
Mouse   162 ----KQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFT 222

  Fly   461 GCNFFGCFQKNCCVRCNYFCSDVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTG 525
            .|.                 .|.||..|..||..||::...|:||..|:|..|.|||.||:|..|
Mouse   223 FCG-----------------RDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVG 270

  Fly   526 IYQTGMRKGLQVLTNNRHIVLKCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHA 590
            ...|..|.|:::.|::|.::|||.:.|:.:.|.|.:...|....|||...:.|.|:||.|..|.|
Mouse   271 KRSTETRYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGSGRDFLQLHQHDSYAPPRPGTLA 335

  Fly   591 TWYVDGAQYMSAVADGLEAALEEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFV 655
            .|:|:||.|.:||||.:..|.|||:|.|||||||||:|||| ..|.||||.:|.||||:||||.:
Mouse   336 RWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEIYLKRPA-HSDDWRLDIMLKRKAEEGVRVSI 399

  Fly   656 LLYKEVEMALGINSYYSKSTL-AKHENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDL 719
            ||:||||:||||||.|||.|| ..|.|||||||||.    :.|||||||::|:||..||:||:||
Mouse   400 LLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDL----VTLWAHHEKLLVVDQVVAFLGGLDL 460

  Fly   720 CYGRWDDHHHRLTDLGSISTSSFSGSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPS 784
            .:|||||..:||||||.
Mouse   461 AFGRWDDVQYRLTDLGD------------------------------------------------ 477

  Fly   785 PPPDEPNTSIELKTLKPGDRLLIPSTLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNA 849
              |.||   :.|:|          .||.|.|..||
Mouse   478 --PSEP---VHLQT----------PTLGSDPAATP------------------------------ 497

  Fly   850 MKGARMGKDFMHRLTATETEEKSAEVYTIESEEATDHEVNLNMASGGQEVAITTSSTQILSEFCG 914
                    |..|                                                ::|
Mouse   498 --------DLSH------------------------------------------------NQF-- 504

  Fly   915 QAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAM 979
               :|.||||||.|.|||:.|:.||.|.|||.|||||||.|||:.|.|.:|||:|||||||||..
Mouse   505 ---FWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFT 566

  Fly   980 KLEKLRDNT-RFPYLMPKSYHQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDA 1043
            |..|.|..| .:|||:|||.......|.:... .|..|.|:||||..||.|     .:|.||.:|
Mouse   567 KTTKARYKTPLYPYLLPKSTSTANNLPFMIPG-GQCATVQVLRSVDRWSAG-----TLENSILNA 625

  Fly  1044 YIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPL 1108
            |:.||.::||::||||||||:...|       ..|.|::|:.:..||::||::.:.||||:::||
Mouse   626 YLHTIRESQHFLYIENQFFISCSDG-------RTVLNKVGDEIVDRILKAHEQGQCFRVYLLLPL 683

  Fly  1109 LPGFEGDVGGSTGIAVRAITHWNYA-----------SISRGRTSILTRLQEAGIANPENYISFHS 1162
            |||||||:....|.:::||.|:.|:           ::.||..|||.||:.|......:|:|...
Mouse   684 LPGFEGDISTGGGNSIQAILHFTYSLCLLHPFFSLRTLCRGEHSILHRLKAAMGTAWRDYMSICG 748

  Fly  1163 LRNHSFLNNTPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMN 1227
            ||.|..|...||:||||:|||:||||||.||.|||||||||::||||||:|.::.|.|.|...|:
Mouse   749 LRTHGELGGHPISELIYIHSKMLIADDRTVIIGSANINDRSLLGKRDSELAILIKDTEMEPSLMD 813

  Fly  1228 GKKYPSGVFAGRLRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVF 1292
            |.:|.:|.||..|||:.|...||     .::..|||:.||||:.|:. .|:..:..|..||:::|
Mouse   814 GVEYQAGRFALSLRKHCFSVILG-----ANTWPDLDLRDPVCDDFFQ-LWQETAENNATIYEQIF 872

  Fly  1293 KCIPTDFVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGL 1357
            :|:|::..::..:||:|.....||..:|.||.:....|||:||..||:||..|.|.||..||||:
Mouse   873 RCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIQGHLVHFPLKFLEDESLLPPLGSKEGM 937

  Fly  1358 IPTSVWT 1364
            ||..|||
Mouse   938 IPLEVWT 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	46/205 (22%)
		PLN02866	388..1349	CDD:215467	387/974 (40%)
Pld2	NP_001289404.1	PLN02866	67..929	CDD:215467	418/1132 (37%)