Protein Alignment Pld and Pld1

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: NP_001355596.1
• Gene: Pld1 / 18805
• MGIID: 109585
• Length: 1074
• Species: Mus musculus
• Alignment Length: 1230
• Identity: 456/1230 - (37%)
• Similarity: 645/1230 - (52%)
• Gaps: 202/1230 - (16%)

  Fly   169 TILSNVGDKPVLVERKET-----DDDEEEFDDEENNSVVLRHEIPFTSIYGPSVKFNSFQRKVFI 228
            |:.....|...|:|..:|     :.:|.|:|....:.......|||:|||. :..|.....:.::
Mouse    13 TLQKIAADMSNLIENLDTRELHFEGEEVEYDASPGDPKAQEGCIPFSSIYN-TQGFKEPNIQTYL 76

  Fly   229 PGREIHVRIVDTER-SVTTHLLNPNLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRTSLNIPF 292
            .|..|..::::.|| :.|:.:.:.||||||||||.|.|.:||::|||...|::|..::..:.||.
Mouse    77 SGCPIKAQVLEVERFTSTSRVPSINLYTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPI 141

  Fly   293 PSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAMAMISPN 357
            |::.|..:|..:|...|||
Mouse   142 PTKRHTFRRQNVKEEPREM---------------------------------------------- 160

  Fly   358 HSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNLLNISLYRSHH 422
                                     |..|...|:.:..|....|.|||||||..:|.:.:||::|
Mouse   161 -------------------------PSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYH 200

  Fly   423 ETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQAGCNFFGCFQKNCCVRCNYFCSDVVCG 486
            .|..|::||.:||:..:|.||.||:|:||:|..| ||           .|||....      .|.
Mouse   201 ATTEFLDVSQLSFIHDLGPKGLEGMIMKRSGGHRIPG-----------VNCCGHGR------ACY 248

  Fly   487 TWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHIVLKCWTR 551
            .|..||..||::...|::|..|:|..|:|.|:.|.|..|..:|..:.||::...:|.::|||.:.
Mouse   249 RWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFRVKVGRKETETKYGLRIDNLSRTLILKCNSY 313

  Fly   552 RKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEAALEEIYI 616
            |..:.|...::.....:..||...:...|:|.:..||.|.|||:...|...:|:.:|.|.|||:|
Mouse   314 RHARWWGGAIEEFIRKHGADFLKDHRFGSYAALHENTLAKWYVNAKGYFEDIANAMEEASEEIFI 378

  Fly   617 ADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKSTLAK-HE 680
            .||||||||::|||.::|:.||||.||.|||:||||:|::||||||:||||||.|||.||.: |.
Mouse   379 TDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYSKRTLMRLHP 443

  Fly   681 NIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSIS--TSSFS 743
            ||||||||||....:.|||||||:|:|||:.||:|||||.||||||:.|||||:||:.  ||..|
Mouse   444 NIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGLS 508

  Fly   744 GSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGDRLLIP 808
            ..:....|:    :..:|.  |.|.....|     |:.|.|...||  |.::||
Mouse   509 LGSLTAASV----ESMESL--SLKDKHEFH-----KKEPISKIVDE--TDMKLK----------- 549

  Fly   809 STLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATETEEKSA 873
                          ||. :..|.:...:.|               ::.:..:|...:..:.:.::
Mouse   550 --------------GIG-KSRKFSKFSLYR---------------QLHRHHLHNADSISSIDSTS 584

  Fly   874 EVYT-IESEEATDH----EVNLNMASGGQEVAITTSSTQI---------LSEFCGQAKYWFGKDY 924
            ..:: ..|.:...|    .:.|...|...|..:|..||..         :.|..|:.::|.||||
Mouse   585 SYFSHCRSHQNLIHGLKPHLKLFHPSSESEQGLTRHSTDTGSIRSVQTGVGELHGETRFWHGKDY 649

  Fly   925 SNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLR-DNT 988
            .||:.|||:.|:.||.|.|||.:||||||||:|..|.|.:|||||||||||||..|:.|.: .:.
Mouse   650 CNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIGSVVHGKAARDVARHFIQRWNFTKIMKPKYRSL 714

  Fly   989 RFPYLMPKSY---HQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITK 1050
            .:|:|:|||.   |::|    .|.........|||||.:.||.|....   |:|||.|||..|..
Mouse   715 SYPFLLPKSQATAHELR----YQVPGAVPAKVQLLRSAADWSAGIKHH---EESIHAAYIHVIEN 772

  Fly  1051 AQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGD 1115
            ::||:||||||||:.       .....|.|::|:.:.:||::||:|.:.:|||:::|||||||||
Mouse   773 SKHYIYIENQFFISC-------ADDKVVFNKVGDAIAQRILKAHREGQRYRVYIVIPLLPGFEGD 830

  Fly  1116 VGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPE------NYISFHSLRNHSFLNNTPI 1174
            :....|.|::||.|:||.::.||.:|||.:|:      ||      |||||..||.|:.|....:
Mouse   831 ISTGGGNALQAIMHFNYRTMCRGESSILEQLK------PELGNKWINYISFCGLRTHAELEGNLV 889

  Fly  1175 TELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGR 1239
            |||||||||||||||..||.||||||||||:||||||:|.|:.|.|.....|:||:|.:|.||..
Mouse   890 TELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARD 954

  Fly  1240 LRKYLFKEHLGLLESEGSSRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTDFVKTFA 1304
            ||...|:..||.|.....     |:.|||.:||:...|...:.:|..|||:||:|:|.|.|....
Mouse   955 LRLECFRLVLGYLSDPSE-----DLQDPVSDKFFKEIWVSTAARNATIYDKVFRCLPNDEVHNLI 1014

  Fly  1305 SLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVWT 1364
            .||.:..:|.|||.....|......|:|:||..||.||::|.|.|...:||.::|..|||
Mouse  1015 QLRDFINKPILAKEDRLRAEEELRKIRGFLVQFPLYFLSEENLLPSVGTKEAIVPMEVWT 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	51/201 (25%)
		PLN02866	388..1349	CDD:215467	399/988 (40%)
Pld1	NP_001355596.1	PLN02866	82..1059	CDD:215467	432/1143 (38%)
		Catalytic	463..928		213/538 (40%)