Protein Alignment Pld and pld-1

DIOPT Version :10

• Sequence 1: NP_001137610.1
• Gene: Pld / 35554
• FlyBaseID: FBgn0286511
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: NP_494939.1
• Gene: pld-1 / 173876
• WormBaseID: WBGene00004040
• Length: 1427
• Species: Caenorhabditis elegans
• Alignment Length: 1496
• Identity: 519/1496 - (34%)
• Similarity: 739/1496 - (49%)
• Gaps: 302/1496 - (20%)

  Fly   102 LTNSDEEH------GSGEEDASEENSNNEEGEGVFRD-----------CTD---EAVV---EHHN 143
            :.:.|||.      .||..:..:...||.....|..|           .:|   :||:   ||..
 Worm     1 MESEDEESRRPQTTSSGHLEPKDTTENNSVDSSVMHDRGIPGLLPATKASDKQKKAVIRFREHEG 65

  Fly   144 RCLPEFQFSLVDSEYDETLAFPDSVTILSNVGDKPVLVERKETDD--DEEEFDDEENNSVVLRHE 206
            |         .||.........||.|:..:....|..::..::||  |::|....:..:..|:..
 Worm    66 R---------ADSPPSNLNVRRDSKTVHIDEVSSPQSLDYGDSDDSSDDDEIQYCDCVAAALQQS 121

  Fly   207 ----------IPFTSIYGPSVKFNSFQRKVFIPGREIHVRIVDTERSVT--THLLNPNLYTIELT 259
                      ||:.|||  ..:..:.:|..:|||..::.:||..||:..  .|.:|..||||||.
 Worm   122 LPGTPGRKGIIPYMSIY--DTQQQARRRGYWIPGVPVNAKIVKVERNTDRGIHFINTLLYTIELE 184

  Fly   260 HGPFKWTIKRRYKHFNSLHQQLSFFRT----------------------SLNI--------PFPS 294
            ||.|:|::.|.||.|..|:.:|...|.                      .::|        |:.:
 Worm   185 HGQFRWSVIRNYKDFTLLNNRLMAHRAREQFMAPIKRTQERFDNYLEHMGIDIISDHKPECPYSN 249

  Fly   295 RSHKEKR-TTLKATAREM--ADESTLKDLPSHTKVKQTSTPL---RAEGRSSKIAGSNANNAMAM 353
            :|.|.|| ..|:...|:.  .:||           |.||.||   .:.|..........:...|:
 Worm   250 QSSKRKRHPKLQVLKRDSDGIEES-----------KNTSAPLASVESPGEVEDAFKKEVHMQQAV 303

  Fly   354 IS------PNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNRPESLVTVENLSVRIKQLEDYLYNL 412
            .|      .|.::...| ||:|.:::::||.:..|||||..|:|:||  ||..|.:.||::|..:
 Worm   304 QSGILDETVNEANTSEG-TPKRQRRQQRKKDRHTLPRFPMMPDSMVT--NLEHRKELLENWLQMV 365

  Fly   413 LNISLYRSHHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTRPGQAGCNFFGCFQKNCCVRCN 477
            |:|.:.|:||||..|:|||..|||..:|.|..||.:.||.|.:|.      |.|  .|.||||
 Worm   366 LHIPINRNHHETAEFLEVSRYSFVNELGGKHTEGFVKKRPGGSRV------FLG--WKQCCVR-- 420

  Fly   478 YFCSDVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQT-GMRKGLQVLTNN 541
            |..      .|..||..|:::...|:......||.|:|.|:.|.|:.|..:| |:..|| ::||:
 Worm   421 YLL------PWSKRWLMVRDSFVAYMDHRTEQIRMVLLMDRDFKVAAGGKETEGIPTGL-IITNS 478

  Fly   542 RH-IVLKCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVAD 605
            :| :.|||...:....|...::.........:..|:...|..|:|.|.||.|:||...||...||
 Worm   479 QHELHLKCRRLQDTATWKYIIEQAMGGIGNTWLQPHRFSSSFPVRENCHAKWFVDAKTYMEYAAD 543

  Fly   606 GLEAALEEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSY 670
            .:|.|.|||||.|||||||||||||||:|:|||||:||.|||||||::|:|||||:|||||:||.
 Worm   544 MMELAREEIYITDWWLSPEIYMKRPALEGNYWRLDEILKRKAEQGVKIFILLYKEMEMALGLNSI 608

  Fly   671 YSKSTL-AKHENIKVMRHPDH-ARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTD 733
            |||.|| ..|||||||||||| ...|...||||||:::|||..:|:||:|||:||||||.|.|||
 Worm   609 YSKRTLQGLHENIKVMRHPDHYPSTGTFFWAHHEKLLIIDQLISFVGGVDLCFGRWDDHRHLLTD 673

  Fly   734 LGS--------ISTSSFSG---------------------------------------------- 744
            |||        ::|:..||
 Worm   674 LGSVQYSGAHQVATNMASGLRSLMTAPLTLSPLGLEEHEKVTPRNENGGKNGSVKRVAVEEINEV 738

  Fly   745 -----STRRTPSLYFTKDD-----------------TDSAFGS--RKSSRNAHYDTSAKERPPSP 785
                 .|.||.....|.::                 ||...|.  .::......|.:.:...|:.
 Worm   739 DEPKEVTGRTQETELTDNEDISEDSDVKKIMEETIFTDKETGGVVVRTLNRFPVDEAIRHSSPAD 803

  Fly   786 PP---DEPNTSIELKTLKPGDRLLIPSTLVSSPGETPAESGIALEGMK--------LNTPEMERK 839
            |.   .|..|::...|...|.   :.|...::...|.......||..|        :.:.|.:||
 Worm   804 PQKNWKETKTTVVESTSTSGG---VTSKTTTTTTTTRVVKDNTLEKEKNKKELRRAVTSLERQRK 865

  Fly   840 NVLDRLKNNA-------MKGARMGKDF-------------------MHRLTATETEEKSAE---- 874
            :|...:.:.|       .|.|:.|.||                   .||........|:.:
 Worm   866 HVPREILDKAGPAPSMIEKAAKSGMDFASAAEKYKEYVASGAVQKEKHRAQTPPNRRKAKKDSRI 930

  Fly   875 -------------------VYTIESEEAT-DHEVN------LNMASGGQEVAITTSSTQILSEFC 913
                               ...:||:||| .:|::      ::....|.:            |..
 Worm   931 TRAVGAVGNWKSNRAKRKWKQMLESDEATMGYELDWLRLREMDEKGDGDD------------EID 983

  Fly   914 GQAKYWFGKDYSNFILKDWMNLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNA 978
            |.||.|:||||.|:|.||::.::.||.|.|||.:||||||||:.....|..|||:||||||||||
 Worm   984 GGAKLWYGKDYVNYIAKDFVEVDMPFHDFIDRGSTPRMPWHDIHSVTFGAPARDLARHFIQRWNA 1048

  Fly   979 MKLEKLRDNTRFPYLMPKSYHQVRLNPNI--QQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIH 1041
            .|.|||:|:..:|||:||||..||: |.:  ..|..:.|..|:|||:|.|| |.|  :..|.||.
 Worm  1049 TKTEKLKDDKNYPYLLPKSYENVRV-PRVFKTANASEMVNVQVLRSLSNWS-GLI--NQTEDSIQ 1109

  Fly  1042 DAYIQTITKAQHYVYIENQFFITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIM 1106
            .||:..|..::||:|||||||::|.       ..|:|.|::.:.::.|||||:||:..:|||:::
 Worm  1110 MAYLSLIANSKHYIYIENQFFVSMI-------ESNDVTNEVCKVIYNRIVRAYKEKDNYRVYIMI 1167

  Fly  1107 PLLPGFEGDVGGSTGIAVRAITHWNYASISRGRTSILTRLQEAGIANPENYISFHSLRNHSFLNN 1171
            |||||||||||...|.:::|:.||.|.|:|:|..|::.|| :|.:.:|..||...|||.:..|..
 Worm  1168 PLLPGFEGDVGAPGGSSLQAVLHWTYQSLSQGPNSLIQRL-KAVMPDPFKYIHVGSLRTYDQLGQ 1231

  Fly  1172 TPITELIYVHSKLLIADDRVVICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVF 1236
            ..::||:|:|.||||.||..||.|||||||||..|.||||:..:..|...|...|:||.:.:|.|
 Worm  1232 KLVSELVYIHCKLLIVDDEHVIIGSANINDRSQCGNRDSEVCCVYTDVVKERSVMDGKPFEAGRF 1296

  Fly  1237 AGRLRKYLFKEHLGLL-ESEGSSRSD--LDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTD 1298
            |..||....:|||||| :|...::..  :..:|||.:.|:...|:..:..|.:||:|||:..|||
 Worm  1297 AKSLRMQCMREHLGLLPDSRRKAKFPYAVSCDDPVADSFFVDVWQSTAKSNGQIYEEVFRSYPTD 1361

  Fly  1299 FVKTFASLRKYQEEPPLAKTAPDLAANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVW 1363
            ||:||...:|:..:.|:::.:|..|..|..|::|.|||.||.||.|.||||..||||||:|::|:
 Worm  1362 FVETFEEFQKWTSQIPMSEYSPQQAEERVRDLKGVLVDFPLNFLCKAVLTPGITSKEGLVPSAVF 1426

  Fly  1364 T 1364
            |
 Worm  1427 T 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld	NP_001137610.1	PX_PLD	230..431	CDD:132805	73/244 (30%)
		PLN02866	388..1349	CDD:215467	420/1114 (38%)
pld-1	NP_494939.1	PLN02866	158..>681	CDD:215467	227/553 (41%)
		PLDc_vPLD1_2_yPLD_like_1	528..674	CDD:197236	100/145 (69%)
		PLN02866	<988..1426	CDD:215467	209/449 (47%)
		PLDc_vPLD1_2_yPLD_like_2	1101..1278	CDD:197239	86/186 (46%)