DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptr and DISP2

DIOPT Version :10

Sequence 1:NP_610209.2 Gene:Ptr / 35546 FlyBaseID:FBgn0262867 Length:1169 Species:Drosophila melanogaster
Sequence 2:NP_277045.1 Gene:DISP2 / 85455 HGNCID:19712 Length:1401 Species:Homo sapiens


Alignment Length:1114 Identity:210/1114 - (18%)
Similarity:359/1114 - (32%) Gaps:363/1114 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 CARWENECFEND--------ILNLDALMDDIEAGQL-NLTFPFMFNPVTWDAHLFPVFFGGTKLT 198
            ||:...:|.::.        :|:.|.|.......|: :|.:..:|.|....|.|..::.      
Human   395 CAQVPTKCSQSSAIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPTPKGASLMDIYL------ 453

  Fly   199 EDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHEL 263
                                    |.....|        |.|:|......:.:. .....|.|.|
Human   454 ------------------------DRLATPW--------GLADNYTSVTGMDLG-LKQELLRHFL 485

  Fly   264 EKNT-----KTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGN-VSAIMATLAAFGLAMY 322
            .::|     ..|..:|.....|..||  :|.|:        .||::|: :.|......||.:|. 
Human   486 VQDTVYPLLALVAIFFGMALYLRSLF--LTLMV--------LLGVLGSLLVAFFLYQVAFRMAY- 539

  Fly   323 CGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMP---VAERMGLMMSEAAVSITITSVTD 384
                |..:||||..|:..:..:.|.:....||.:|:::|   :|:|:|..|......:.::.:|.
Human   540 ----FPFVNLAALLLLSSVCANHTLIFFDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTT 600

  Fly   385 FISFLIGIISPFRSVRIFCTYSVFAV----CFTFLW-------HITFFAACMA------ISGYRE 432
            ..:|....:|...:||....:...||    ..|.:|       |..:.|...|      ..|...
Human   601 SAAFYASYLSRLPAVRCLALFMGTAVLVHLALTLVWLPASAVLHERYLARGCARRARGRWEGSAP 665

  Fly   433 RKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINN 497
            |:.|.::.. |::.:..|.......|::.::..|:                :.|           
Human   666 RRLLLALHR-RLRGLRRAAAGTSRLLFQRLLPCGV----------------IKF----------- 702

  Fly   498 KWCKAIIILAFASYLVGACYGITQIKEGLERRKLSR------EDSYSVEFFDREDDYYRE---FP 553
               :.|.|..||:...|..| |..:...|....|..      ..|:..|.||.|   ||:   |.
Human   703 ---RYIWICWFAALAAGGAY-IAGVSPRLRLPTLPPPGGQVFRPSHPFERFDAE---YRQLFLFE 760

  Fly   554 YRMQ--------VIIAG--PLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERN 608
            ...|        |::.|  |::..|||   ...:.:|.:...::..|....:.||.: |....||
Human   761 QLPQGEGGHMPVVLVWGVLPVDTGDPL---DPRSNSSLVRDPAFSASGPEAQRWLLA-LCHRARN 821

  Fly   609 NELLNVTVDDEQTFIDAVKEHWL------------------------------FPGNP-FSLD-- 640
                       |:|.|.::|.|.                              ||..| |.|.  
Human   822 -----------QSFFDTLQEGWPTLCFVETLQRWMESPSCARLGPDLCCGHSDFPWAPQFFLHCL 875

  Fly   641 ----VRFNEDETQIIASRF-----LIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFF 696
                :....|.||.:..||     |...|....||..                |:..::...:|:
Human   876 KMMALEQGPDGTQDLGLRFDAHGSLAALVLQFQTNFR----------------NSPDYNQTQLFY 924

  Fly   697 DQ---------------------------FELVRPVSLQ-AMVIGAIIMMIISFVFIP--NILCS 731
            ::                           :.|...:|.: |:|:|..:.:..:.:.:.  |:..|
Human   925 NEVSHWLAAELGMAPPGLRRGWFTSRLELYSLQHSLSTEPAVVLGLALALAFATLLLGTWNVPLS 989

  Fly   732 LWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVRE 796
            |:...:|....|...|.:.|.:..|::...:.|...:|.|||||.:.|.:|.........:||..
Human   990 LFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDFTVNYCISYHLCPHPDRLSRVAF 1054

  Fly   797 ALHSLGLPIIQGSSSTILGIVALLLA-------------QSYIFLVFFKMV---FLVIFFGAMHG 845
            :|.       |.|.:|.:|..||..|             :..|.|:..|.|   |...||.:   
Human  1055 SLR-------QTSCATAVGAAALFAAGVLMLPATVLLYRKLGIILMMVKCVSCGFASFFFQS--- 1109

  Fly   846 LFLLPVLLSLFGP-GSC---------LTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYYMQYPSIG 900
                  |...||| .:|         |.|           |.|..|...||            .|
Human  1110 ------LCCFFGPEKNCGQILWPCAHLPW-----------DAGTGDPGGEK------------AG 1145

  Fly   901 INGPYGSKGFLGAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRESP--TR 963
            ...|....|..|:..:.|.:..    |......|.::|::.|:...:.:...|::.:.:.|  :|
Human  1146 RPRPGSVGGMPGSCSEQYELQP----LARRRSPSFDTSTATSKLSHRPSVLSEDLQLHDGPCCSR 1206

  Fly   964 RYDDGWRRSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHE---QQQRQRQRRSPFENYR 1025
                              .....|.|            |:.|..|:   .|....|..||   |:
Human  1207 ------------------PPPAPASP------------RELLLDHQAVFSQCPALQTSSP---YK 1238

  Fly  1026 QDVEIDMQKARRNSHGDVID-LHGTPNSSVEERFRRRGEP-----FSAESGDDSSYRHQQIMAMP 1084
            |.......:||::|.|:..: |..:|.:.......:..:|     .||.:.:..|...:..::. 
Human  1239 QAGPSPKTRARQDSQGEEAEPLPASPEAPAHSPKAKAADPPDGFCSSASTLEGLSVSDETCLST- 1302

  Fly  1085 AAGSAPSAK 1093
               |.|||:
Human  1303 ---SEPSAR 1308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtrNP_610209.2 Patched 53..845 CDD:308203 161/843 (19%)
DISP2NP_277045.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..138
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..264
Sterol-sensing <574..639 CDD:463544 14/64 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1169..1192 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1229..1337 19/87 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1352..1401
Blue background indicates that the domain is not in the aligned region.

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