Protein Alignment Ptr and DISP3

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_065831.1
• Gene: DISP3 / 57540
• HGNCID: 29251
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 1138
• Identity: 184/1138 - (16%)
• Similarity: 351/1138 - (30%)
• Gaps: 434/1138 - (38%)

  Fly    94 RFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATTTYDGDTYTYKDNCARWENECFENDILNL 158
            |...:.:...|.:.|:...|....:.:::..|.        |...:::.|  |:    .:::|.
Human   274 RIELIFLARGDAERNIFTSERLVTIHEIERKIM--------DHPGFREFC--WK----PHEVLK- 323

  Fly   159 DALMDDIEAGQLNLTFPFMFNPVTWDAHLFPVFFGG----------------------------- 194
                 |:..|..:...|    |.:...:.||...||
Human   324 -----DLPLGSYSYCSP----PSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYW 379

  Fly   195 ---TKLTEDNYVISVPAIQLVY------FVTADTK--RQDAKGAEWEETFLRVVGNAENSGQFKH 248
               ..|:.||...|:...::::      :.:.|.:  .|.||...:..|::.::.....|    .
Human   380 YVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTS----K 440

  Fly   249 ISVSYFASRTLDHELEK--NTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIM 311
            :.|.|..:...|:|:.:  |...::.:.||:.:...::.:.:|.:        ||...|..|..:
Human   441 VQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSV--------FLSFFGIASIGL 497

  Fly   312 ATLAAFGLAMY---CGIEFIGI-NLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSE 372
            :.|.|  |.:|   .||:::|| |..|.|:::|||:||.||.:..:|:.........||...:..
Human   498 SCLVA--LFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQT 560

  Fly   373 AAVSITITSVTDFISFLIGIISP---------FRSVRIFCTYSVFAVCFTF-----LWHI---TF 420
            |..:...||:|...::...:.|.         |.|:.:.|.:  .||..|.     ||.:   ..
Human   561 AGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCW--LAVLVTMPAALGLWSLYLAPL 623

  Fly   421 FAACMAI--SGYRERKNLH---SIFGCRVQ-------------------------PMSVAIKEKR 455
            .::|...  .....:.:||   .:|....|                         |:|:.:.:
Human   624 ESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSLELGD-- 686

  Fly   456 NFLYKAIMAGGIDANDPDNPIDNKDHMLM----AFFKDKMAAVINNKWCKA-------IIILAFA 509
                .::::...:...|.:...::.|:::    ......:.:.:.::|...       |:.|.||
Human   687 ----VSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSILILSLVFA 747

  Fly   510 SYLVGA--------------------------------CYGITQ---------IKEGLERRKLSR 533
            |.|..|                                |.|:.|         |:..||:::...
Human   748 SRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNIRTSLEKKRRGS 812

  Fly   534 EDSYSVEFFDREDDYYREFP----------------YRMQVIIAGPLNYSDPLVQEQV------- 575
                .|.:..|.:...::||                ||:.      ||.|.|...:.|
Human   813 ----GVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLS------LNASLPAPWQAVSPGDGEV 867

  Fly   576 --------------ENLTSTLEHTSYVTSRRYTESWLRSFL------------SFLERNNE---- 610
                          :.||:.:.....:.:...:..|:.:.|            ||.....|
Human   868 PSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKRGWKFDFSFYVATKEQQHT 932

  Fly   611 ------------------------LLNVTVDDEQT---FIDAVKEHWLFPGNPFSLDVRFNE--- 645
                                    ||:.:.|....   |:.:.|    .|....|....||.
Human   933 RKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFVPSEK----VPKARLSATFGFNPCVN 993

  Fly   646 ------------DETQIIASRFLIQAVNIT----------------DTNHE--KEMVRDLRQICK 680
                        |...::...|.|..||.|                |::.:  || :..|..:||
Human   994 TGCGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKE-IGHLCHLCK 1057

  Fly   681 DSPLNASIFHP---------YFV--FFDQF-----ELVRP------------------------- 704
            ....|:.:..|         |.:  |....     ||..|
Human  1058 AIAANSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMA 1122

  Fly   705 -------------------------------------------------------VSLQAMVIGA 714
                                                                   |.:|:.:.|.
Human  1123 FESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGL 1187

  Fly   715 IIMMIISF----VFIPNILCSLWVAFSVISIELGVAG--YMALWDVNLDSISMINLIMCIGFSVD 773
            ::.::|..    ||..:||..|.|..|::.|...|..  |.:.|:  :.::..|:|.:.:|.|||
Human  1188 VLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWE--MGAVEAISLSILVGSSVD 1250

  Fly   774 FTAHICYTYMSSKKRSP-----------KARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIF 827
            :..|:...|:.:.:..|           :.|..||:..:|:.|:..:.:|::..|.|.......|
Human  1251 YCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPF 1315

  Fly   828 LVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGS 860
            ..|.|:|.|......::.|.:...||.:..|.|
Human  1316 AKFGKIVALNTGVSILYTLTVSTALLGIMAPSS 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	179/1121 (16%)
DISP3	NP_065831.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..40
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..248
		MMPL	<431..>616	CDD:440656	45/200 (23%)
		MMPL	<1187..>1344	CDD:440656	37/158 (23%)