Protein Alignment Ptr and PTCHD3

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001382672.1
• Gene: PTCHD3 / 374308
• HGNCID: 24776
• Length: 954
• Species: Homo sapiens
• Alignment Length: 876
• Identity: 275/876 - (31%)
• Similarity: 477/876 - (54%)
• Gaps: 59/876 - (6%)

  Fly     3 CGISCVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQL--KYQIDPEYLFSPIAGEG 65
            |...|::..|:::|..||..:..||..|::.|::||....||:..|  ..:.|.|..::|:....
Human   114 CHTDCLEGLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPA 178

  Fly    66 KTERAIVEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQNATT 130
            |.||..|:.:|..|.::||:..|.:....|..::|::.  .::::....|.|:.:||..:|:...
Human   179 KAERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSY--SDSLLDPATFAEVSKLDGAVQDLRV 241

  Fly   131 TYD-GDTYTYKDNCARWENECFE----------NDILNLDALMDDIEAGQLNLTFPFMFNPVTWD 184
            ..: |....|:..|||:...|..          |..|||.           :::|| .:|.....
Human   242 AREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLS-----------SISFP-AYNHGRHP 294

  Fly   185 AHLFPVFFG---GTKLTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQF 246
            .:|...|.|   |..|.....::...|::|:|::..:....|.:..:|....|....|.:|....
Human   295 LYLTGFFGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILAL 359

  Fly   247 KHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIM 311
            |.|.|.:|.|.:...|.|..:.||:|.|...::|:.||::.:|...|.:|:|..:...|.:||.:
Human   360 KKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISAFL 424

  Fly   312 ATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVS 376
            |.::.|||.::.|:.|:.|...:|||::|:|:||.|:|::.|.:|.....:.|||..:.|:||||
Human   425 AVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVS 489

  Fly   377 ITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFG 441
            ||||::|:.::...||:|.||||:.||.|:...:.|.:.::||.|.|.||:.|.||...|
Human   490 ITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREVVCL----- 549

  Fly   442 C---RVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKD-HMLMAFFKDKMAAVINNKWCKA 502
            |   :..|...:.|:...|.:.::         ||.  ...| |.:..||:|.....:.....|.
Human   550 CWLKKADPKWPSFKKFCCFPFGSV---------PDE--HGTDIHPISLFFRDYFGPFLTRSESKY 603

  Fly   503 IIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYS 567
            .::..:..|::.:.||...::|||:.|.|:.:|||...:|:.|::|:.::..|:.||:...::|.
Human   604 FVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVTKKVDYW 668

  Fly   568 DPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWL- 631
            |..|::::||.|...|...|| .:..||.||.:::.:|:.|::..|    ::.||::.:.:...
Human   669 DKDVRQKLENCTKIFEKNVYV-DKNLTEFWLDAYVQYLKGNSQDPN----EKNTFMNNIPDFLSN 728

  Fly   632 FPGNPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFF 696
            ||.  |..|:..: ...:||:||..||..:::.:..:|.::..||:|.:|..:...:::..|::|
Human   729 FPN--FQHDINIS-SSNEIISSRGFIQTTDVSSSAKKKILLFQLRRIAEDCQIPLMVYNQAFIYF 790

  Fly   697 DQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISM 761
            ||:..:...:::.:::.:..|.|:|.:.||..||||||.|::.|:.:||.|:||.|.||||||||
Human   791 DQYAAILEDTVRNVLVASAAMFIVSLLLIPYPLCSLWVTFAIGSVIVGVTGFMAFWKVNLDSISM 855

  Fly   762 INLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYI 826
            |||::|||||.||:.||.|.::||.:.|...:..|||:.||.|::|.:.|||:|:..|..|::||
Human   856 INLVICIGFSFDFSVHISYAFVSSSQPSVNQKSVEALYLLGYPVLQSAISTIIGVCVLAAAKAYI 920

  Fly   827 FLVFFKMVFLVIFFGAMHGLFLLPVLLSLFG 857
            |..|||::|||:.|||.|||..:||.|:.||
Human   921 FRTFFKIMFLVMIFGAAHGLIFIPVFLTFFG 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	252/810 (31%)
PTCHD3	NP_001382672.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103
		PspC_subgroup_2	<2..>80	CDD:468202
		Patched	171..952	CDD:308203	258/819 (32%)