Protein Alignment Ptr and Disp2

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001101229.2
• Gene: Disp2 / 311324
• RGDID: 1309569
• Length: 1346
• Species: Rattus norvegicus
• Alignment Length: 1035
• Identity: 202/1035 - (19%)
• Similarity: 349/1035 - (33%)
• Gaps: 332/1035 - (32%)

  Fly   143 CARWENECFEND--------ILNLDALMDDIEAGQL-NLTFPFMFNPVTWDAHLFPVFFGG---- 194
            ||:...:|..:.        :|:.|.|.......|: :|.|..:|.|:...:.|..::..|
  Rat   350 CAQVPAKCTGSSAVYQLLHFLLDRDFLSPQTADYQVPSLKFALLFLPIIKTSSLLDIYLDGLGDP 414

  Fly   195 TKLTEDNYVISVPAIQ-------LVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVS 252
            .|:: |||. |:..:.       |.|::..||                         .:..:|:
  Rat   415 IKVS-DNYT-SISGMDLGLKPRLLKYYLAEDT-------------------------MYPLLSL- 451

  Fly   253 YFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATL--- 314
                             |:.:|..:..|..||  ||           |:.|:|.:.::|...
  Rat   452 -----------------VIIFFGMSLYLRSLF--IT-----------FMSLLGVLGSLMVAFFLY 486

  Fly   315 -AAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMP---VAERMGLMMSEAAV 375
             .||.:|.     |..:|||:..|:.|:.::.|.:....||.::.::|   :|.|:|..|.....
  Rat   487 HVAFRMAY-----FPFVNLASLLLLSGVCVNYTLIFFDLWRLSRGQVPSGGLAHRVGRTMHHFGY 546

  Fly   376 SITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVC----FTFLWHITFFAACMAISGYRERKNL 436
            .:.::.:|...:|....:|...:||.|..:...||.    .|.||    ..|.:.:   .||...
  Rat   547 LLLVSGLTTSAAFYGSYLSRLPTVRCFALFMGTAVLVHMGLTLLW----LPATVVL---HERYLA 604

  Fly   437 HSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFK-----DKMAAVIN 496
            |   ||..|...              ..||.|      |:    .:|:|..:     .|:.::::
  Rat   605 H---GCVAQAQG--------------QRGGSD------PL----RLLLALHRRIRILRKIFSILS 642

  Fly   497 NKWCKAII-----------ILAFASYLVGACY--GITQIKEGLERRKLS---------REDSYSV 539
            ....:.::           |..||:...|..|  |::      .|.:|.         ...|:..
  Rat   643 RLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIGGVS------PRLRLPILLPLGGQFFRSSHPF 701

  Fly   540 EFFDREDDYYREFPYRMQ----------------VIIAG--PLNYSDPLVQEQVENLTSTLEHTS 586
            |.||.|        ||.|                |::.|  |::.||||   .....:|.:....
  Rat   702 ERFDAE--------YRQQFLFEDLPPNEGGNLPVVLVWGILPVDTSDPL---DPRTNSSVVSDPD 755

  Fly   587 YVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQT--FIDAVKEHWL------------------ 631
            :..|....:.||::.....: |........:...|  .::|::: |:
  Rat   756 FSPSSPEAQEWLQALCQGAQ-NQSFFGDQPEGWPTLCLVEALQQ-WMESPSCGRLGADLCCGQSE 818

  Fly   632 FPGNP-------FSLDVRFNEDETQIIASRF-----LIQAVNITDTN----------HE--KEMV 672
            ||..|       ..:.:..:.|.|:.:..||     |...|....||          |.  .|:.
  Rat   819 FPWAPQLYLHCLKMMALEQSPDGTRDLGLRFDSHGNLAALVLKFQTNLPYSTEYGPVHHFYTEVS 883

  Fly   673 RDLRQICKDSP--LNASIFHPYFVFFDQFELVRPVSLQ-AMVIGAIIMMIISFVFIP--NILCSL 732
            |.|......:|  ||...|..   ..:.:.|...:|.: |:|:|..:.:..:.:.:.  |:..||
  Rat   884 RWLSTEMSKAPPGLNKGWFTS---TLELYSLQHSLSTEPAVVLGLALALAFATLLLGTWNVPLSL 945

  Fly   733 WVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREA 797
            :...:|....|...|.:.|.:..|::...:.|...:|.|||.|.:.|.:|.........:||..:
  Rat   946 FSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDLTVNYCISYHLCPHPDRLSRVAFS 1010

  Fly   798 LHSLGLPIIQGSSSTILGIVALLLAQSYI-----FLVFFKM---VFLVIFFGAMHGLFLLPVLLS 854
            |.       |.|.:|.:| ..:|.|...|     .|::.|:   |.:|.|.|.....|....|..
  Rat  1011 LR-------QTSRATAMG-TGVLFASGVIMLPSTILLYRKLGIIVMMVKFLGCGFASFFFQSLCC 1067

  Fly   855 LFGP-GSC---------LTWTGKDDGSDAEVDDGLDDRQLEKP--FSQSYYMQYPSIGINGPYGS 907
            .||| .:|         |.|       ||..:|. |::....|  ||:.|.:|
  Rat  1068 FFGPEKNCGQILWPCAHLPW-------DAGTEDP-DEKGRTGPPGFSEHYELQ------------ 1112

  Fly   908 KGFLGAPYKAYGVDEKDLGLGTSGEDSSESSSSRSQHRQQAAATE----------EEVVVRESPT 962
                            .|....|....:.:::|:..||....:.:          :...|..||.
  Rat  1113 ----------------PLARRRSPSFDTSTATSKLSHRPSILSEDLQIHDGSCCLQHAQVPVSPR 1161

  Fly   963 RRYDDGWRRSSYQNIYGQGAAQFQAQPDLYGKQVSATEWRQRLDTHEQQQRQRQRRSPFE 1022
            ....|      :|.::.|..|...:.|  | |||....     .|..:|..|.|:..|.:
  Rat  1162 DLLLD------HQTVFSQCPALQTSSP--Y-KQVGPNP-----QTWIRQDSQGQKTEPLQ 1207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	163/834 (20%)
Disp2	NP_001101229.2	MMPL	<448..604	CDD:440656	43/198 (22%)