Protein Alignment Ptr and ptch1

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001292471.1
• Gene: ptch1 / 30189
• ZFINID: ZDB-GENE-980526-196
• Length: 1475
• Species: Danio rerio
• Alignment Length: 1478
• Identity: 290/1478 - (19%)
• Similarity: 481/1478 - (32%)
• Gaps: 498/1478 - (33%)

  Fly    17 YHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNYT 81
            :.||..|.|:.|.|:::.:|:......|.:....:.|.|.|:..:.|.       |.|..|  ||
Zfish    77 FKLGCYIQKNCGKFLVVGLLIFGAFAVGLRAANLETDVEKLWVEVGGR-------VNQELK--YT 132

  Fly    82 HRFNVGR---------ITRPGRFGRVIVITK------DGDENMIRREVFQELRQ----------- 120
             |..:|.         |..|.:.|..|:..:      |......|..|:...||
Zfish   133 -RQKIGEEAMFSPQLMIQTPRQEGANILTVEALKQHLDSAIKASRVHVYMYNRQWTLEHLCYKSG 196

  Fly   121 --------LDNIIQN--------------------------------ATTTYD-----GDTYTYK 140
                    :|.|::.                                ..|.:|     .:....|
Zfish   197 ELVTETNVVDQILEKLHPCLVITPLDCFWEGAKLHSGTFYLPGKPPLQWTNFDPMGFIAELKMLK 261

  Fly   141 DNCARWENECFENDI----LNLDALMD-----DIEAGQLNLTFPFMFNPVT-------------W 183
            .....||....:.|:    :|...|..     .:.|...|.|.||...||.             |
Zfish   262 YQVDSWEEMLVKADVGQGYMNRPCLNPADPDCPLSAPNKNTTGPFDVAPVLTGGCYGLSKKYMHW 326

  Fly   184 DAHLFPVFFGGTKLTEDNYVISVPAIQLVY-FVTADTKRQDAKGAE------------------W 229
            ...|   ..||||..:...::|..|.|.:: .:|.....:..||.:                  |
Zfish   327 QEEL---IVGGTKKNDSGKLLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILEAW 388

  Fly   230 EETFLRVVGNA--ENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMG 292
            :..:...|..:  .||.|    .|..|.:.||:..|:..:...|...:|.:|||..::.:|.:..
Zfish   389 QRKYSEAVQQSVPVNSSQ----KVLTFTTTTLEDILKSFSDVSVIRIASGYLLMLAYACLTMLRW 449

  Fly   293 DAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAA----PFLMIGIGIDDTFVMLAGW 353
            |..:|:..:||.|.:...::..|..||....||.|   |.|.    |||.:|:|:||.|::...:
Zfish   450 DCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISF---NAATTQVLPFLALGVGVDDVFLLAHAF 511

  Fly   354 RRT--KAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLW 416
            ..|  ..::|..:|.|..:.....|:.:||:::..:|.:..:.|..::|.|...:...|.|.|..
Zfish   512 SETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAM 576

  Fly   417 HITFFAACMAISGYRERKNLHSIFGCRVQP----------------------------------- 446
            .:..|.|.:::..||.......||.|.|.|
Zfish   577 VLLIFPAILSMDLYRREDRRFDIFCCFVSPCANRVIQLEPQAAYADSSADSSRYSPPPSYSSHSF 641

  Fly   447 ---------MSVAIK---EKRNFLY---------------------------------------K 460
                     .:|.::   :.|...|                                       .
Zfish   642 AQHTQITMQSTVQLRTEYDPRTQAYYTTAEPHSHISVQPYAPNTNPNPNPNRNNNNNNCTNNSSS 706

  Fly   461 AIMAGGID---ANDPDNPIDNKDHMLMAFFKDKMAAVIN---NKW------------------CK 501
            |:.....|   ...||.....:|  |::.|.|.....::   ::|                  .|
Zfish   707 AVPGVATDTASCQSPDGASSTRD--LLSQFGDSGIRCLDSPYSRWTFASFAEKHYAPFLLQSTTK 769

  Fly   502 AIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNY 566
            .::|..|.:.|..:.||.|::::|||...:...::...:|...:   :|.|.:....::....:|
Zfish   770 VVVIFLFLALLGVSLYGTTRVRDGLELTDIVPRETGEYDFIRAQ---FRYFSFYNMYVVTQRADY 831

  Fly   567 SDPLVQEQVENLTSTLEHTSYV---TSRRYTESWLRSFLSFL--------------------ERN 608
            :.  :|.|:..|........|:   .:.:....||..|..:|                    .||
Zfish   832 AQ--IQPQLYELHQRFGSVKYILREENGQLPRMWLHYFRDWLLGLQEAFDKDWQAGRITQGNYRN 894

  Fly   609 N--------ELLNVTVDDEQT--------------------FIDA---------------VKEH- 629
            .        :||..|...|:|                    ::.|               ::.|
Zfish   895 GSDDGVLAYKLLVQTGRREKTITRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPHP 959

  Fly   630 --WLFPGNPFSLDVRFNEDETQII-ASRFLIQAV-------------NITDTNHEKEMVRDLRQI 678
              ||             .|.|..| |||..|.|.             .:.:|....|.:..:|.|
Zfish   960 PEWL-------------HDRTDSIPASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAI 1011

  Fly   679 CKDSPLNASIFHPY---FVFFDQFELVRPVSLQAMVIGAI-IMMIISFVFIPNILCSLWVA---- 735
            |.:........:|.   |:|::|:     |.|:..::.:| :::..:|:.....|.:.|.|
Zfish  1012 CNNFSRQGLPSYPNGYPFLFWEQY-----VGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIV 1071

  Fly   736 --FSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSS-KKRSPKARVREA 797
              .|::::||  .|.|.|..:.|.::.::.||..:|..|:||.|:...:::: ..|:.:|.:  |
Zfish  1072 LVLSLMTVEL--FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDRNKRAVL--A 1132

  Fly   798 LHSLGLPIIQGSSSTILGIVALLLAQS---YIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPG 859
            |..:..|::.|:.||:||:  |:||.|   :|...||.::.::...|.::||.|||||||.|||
Zfish  1133 LEHMFAPVLDGAFSTLLGV--LMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGP- 1194

  Fly   860 SCLTWTGKDDGSDAEVDDGLDDRQLEKPFSQSYYMQYPSIGINGPYGSKGFLGAPYKAYGVDEKD 924
                   ..:.|.|:....|.....|.|.....:...||....|
Zfish  1195 -------YPEVSPADGQSRLPTPSPEPPPQVVRFTMRPSHTTPG--------------------- 1231

  Fly   925 LGLGTSGEDSSESSSSRSQHRQQAAATEEEVVVRESPTRRYDDGWRRSSYQNIYGQGAAQFQAQP 989
                 :|.|||:|.
Zfish  1232 -----AGSDSSDSE--------------------------------------------------- 1240

  Fly   990 DLYGKQVSATEWRQRLDTHEQQQRQRQRRSPFENYRQDVEIDMQKARRNSHGDVIDLHGTPNSSV 1054
              ||...:.:...|.|..:..|. .|.|.:..|      |:.:..|.|.....| :|...|:.|
Zfish  1241 --YGSNTTVSGISQELQQYNLQP-NRGRSARLE------EVRIATAGRQGSRQV-ELPMFPSCS- 1294

  Fly  1055 EERFRRRGEPFSAESGDDSSYRHQQIMAMPAAGS---APS-AKRYHRRRSSEDSTSRHQRWPANI 1115
                            |||  |.|||.....:.|   ||. :|||..|....|..|.|...|...
Zfish  1295 ----------------DDS--RQQQIQQHYRSSSHDAAPQPSKRYCSRDPKRDFGSGHPPPPHRP 1341

  Fly  1116 EERRARRAYSP-AHNRPETALTSYAYRSSSHHNLYQPNGKSSKYPPTY 1162
            .......|..| .|:.|.....|.|:|..| ||.|.|:.......|.|
Zfish  1342 RMDAFETATEPGGHSGPNHRDRSGAHRPRS-HNPYNPHPSHPSTGPNY 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	210/1118 (19%)
ptch1	NP_001292471.1	2A060602	30..1220	CDD:273338	235/1201 (20%)