Protein Alignment Ptr and NPC1L1

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_037521.2
• Gene: NPC1L1 / 29881
• HGNCID: 7898
• Length: 1359
• Species: Homo sapiens
• Alignment Length: 1040
• Identity: 224/1040 - (21%)
• Similarity: 405/1040 - (38%)
• Gaps: 252/1040 - (24%)

  Fly     4 GISCVDK-------TLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPI 61
            |.|..||       .|.:.|...|..:|..|...:::.|:..:....|....:...||..|:|..
Human   322 GTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAP 386

  Fly    62 AGEGKTERAIVEQYFKVNYTHRFNVGRITRPG----RFGRVIVITK------DGDENMIRREVFQ 116
            ..:.::|:|..:|:|...:  |.|...:|.|.    |:..:::..|      |.|..:...|:.:
Human   387 NSQARSEKAFHDQHFGPFF--RTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQE 449

  Fly   117 ELRQLD--------NI-IQN-ATTTYDGDTYTYKDNCARWENECFEND--ILNLDALMDDIEAGQ 169
            .||.|.        || :|: .....:.|..:..|.|.....:.|:|:  :|.|.|
Human   450 RLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTA--------- 505

  Fly   170 LNLTFPFMFNPVTWDAHLF-------------------------PVF----FGGTK---LTEDNY 202
             |.|.....:.|.|..|..                         |||    .||.|   .:|...
Human   506 -NQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEA 569

  Fly   203 VISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAEN--SGQFKHISVSYFASRTLDHELEK 265
            :|.  ...|..:...|.:...||  .|||.||..:...:.  :|.|:   |::.|.|:|:.|:.:
Human   570 LIM--TFSLNNYPAGDPRLAQAK--LWEEAFLEEMRAFQRRMAGMFQ---VTFMAERSLEDEINR 627

  Fly   266 NTKTVVPYFSSTFLLMGLFSIITCMMGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMYC 323
            .|...:|.|::::::  :|..|:..:|.       .|.||..|||.|....:.|.:||.|...|.
Human   628 TTAEDLPIFATSYIV--IFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYL 690

  Fly   324 GI-EFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAK--MPVAERMGLMMSEAAVSITITSVTDF 385
            || ..:.|....|||::.:|.|:.|:.:..::|...:  .|....:|..:...|.|:.:.|:::.
Human   691 GIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEA 755

  Fly   386 ISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVA 450
            |.|.:|.::|..:||.|...|..||...||..::.|.|.:::...|:..:...:. |.|:|..:.
Human   756 ICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVC-CCVKPQELP 819

  Fly   451 IKEKRNFLYKAIMAGGIDANDPDNPIDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGA 515
                                    |....:.:|:.||:...|..:.:...:.:::|.|.:....:
Human   820 ------------------------PPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVS 860

  Fly   516 CYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPL--------NYSDPLVQ 572
            .|.:..|..||::.....:|||.:::|...:.|:.         :..|:        |:|.....
Human   861 LYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFE---------VGAPVYFVTTLGYNFSSEAGM 916

  Fly   573 EQV--------ENLTSTLEHTSYVTSRRY----TESWLRSFLSFLERN----------------- 608
            ..:        .:.|..:::.:....:.|    ..||:..|:.:|..:
Human   917 NAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCP 981

  Fly   609 ---NEL------LNVTVDDEQTFIDAVKEH--WLFPGNP-----------FSLDVRFNED----E 647
               |.|      :::|:...:..::...::  |.....|           :|..|....|    :
Human   982 STVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLD 1046

  Fly   648 TQII----------------------ASRFLIQAVNITDTNHEKEMVR-----------DLRQIC 679
            |..|                      .|||:.....:.::....|.:|           |||::.
Human  1047 TVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVP 1111

  Fly   680 KDSPLNASIFHPYF---VFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCS---------- 731
            ...|  |....||.   ||::|:..:.|..|          .::|...:|....|
Human  1112 GTDP--AFEVFPYTITNVFYEQYLTILPEGL----------FMLSLCLVPTFAVSCLLLGLDLRS 1164

  Fly   732 -LWVAFSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVR 795
             |....|::.|.:...|:||||.::.:::|:|||:..:|.||:|.:||..::..|.|.:...|.:
Human  1165 GLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAK 1229

  Fly   796 EALHSLGLPIIQGSSSTIL-GIVALLLAQSYIF-LVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
            ||..|:|..:..|.:.|.| ||:.|.||::.:. :.||::..|:...|.:|||..|||:||..||
Human  1230 EATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1294

  Fly   859  858
            Human  1295  1294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	203/969 (21%)
NPC1L1	NP_037521.2	2A060601	33..1293	CDD:273337	222/1037 (21%)