Protein Alignment Ptr and Npc1

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_705888.2
• Gene: Npc1 / 266732
• RGDID: 628693
• Length: 1278
• Species: Rattus norvegicus
• Alignment Length: 993
• Identity: 223/993 - (22%)
• Similarity: 402/993 - (40%)
• Gaps: 215/993 - (21%)

  Fly     9 DKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVE 73
            |..|.:.|...|....::|...|...::....|.:|...::...:|..|:|....:.:.|:
  Rat   333 DDCLRRMFTKWGAFCVRNPTCIIFFSLVFIAACSSGLVFVQVTTNPVELWSAPHSQARLEK---- 393

  Fly    74 QYFKVNYTHRFNVGR--ITRPGRFGRVIVITKDGDE----NMIRREVFQELRQLDNIIQNATTTY 132
            :||..::...|...:  |..|.....:......|.:    ..:.:|:..::..|...|::.|.:|
  Rat   394 EYFDKHFGPFFRTEQLIIQAPNSSVHIYEPYPSGADVPFGPPLNKEILHQVLDLQIAIESITASY 458

  Fly   133 DGDTYTYKDNC----ARWENEC--------FENDILNLDALMDD---------------IEA-GQ 169
            :.:|.|.:|.|    :.:...|        |:|....||..:.|               :.| ..
  Rat   459 NNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDNQVGDDFFVYADYHTHFLYCVRAPAS 523

  Fly   170 LNLTFPFMFNPV--TWDAHLFP-VFFGGTKLTEDNY------VISVPAIQLVYFVTADTKRQDAK 225
            ||.| ..:..|.  |:...:|| :..||  ..:.||      ||:.|...  |:  .||::....
  Rat   524 LNDT-SLLHGPCLGTFGGPVFPWLVLGG--YDDQNYNNATALVITFPVNN--YY--NDTEKLQRA 581

  Fly   226 GAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCM 290
            .| ||:.|:..|.|.:|    .::::|:.|.|:::.||.:.:.:.|  |:.......:|..|:..
  Rat   582 WA-WEKEFINFVKNYKN----PNLTISFTAERSIEDELNRESNSDV--FTVLISYAVMFLYISLA 639

  Fly   291 MGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINL-AAPFLMIGIGIDDTF 347
            :|.       .|.||..||:.|.:..:.:...:.|:..|.|:....|.: ..|||::.:|:|:.|
  Rat   640 LGHIQSWNRVLVDSKISLGIAGILIVLSSVTCSLGIFSYIGMPLTLIVIEVIPFLVLAVGVDNIF 704

  Fly   348 VMLAGWRRTK--AKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAV 410
            :::..::|.:  .:..:.:::|.::.|.|.::.::|.::..:|..|.:|...:|..|..::..||
  Rat   705 ILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAV 769

  Fly   411 CFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNP 475
            ...||..||.|.:.:.:...|:.||...|..|                          ...||:.
  Rat   770 LIDFLLQITCFVSFLGLDIKRQEKNRLDILCC--------------------------VRGPDDG 808

  Fly   476 IDNK--DHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYS 538
            .:::  :..|..|||:..|..:...|.:.:::..|...|..:...:.:::.||::......|||.
  Rat   809 QESQASESYLFRFFKNAFAPFLLTDWLRPVVMAVFVGILSFSIAVVNKVEIGLDQSLSMPNDSYV 873

  Fly   539 VEFFDREDDYYREFPYRMQVIIAGPLNYS----------------DPLVQEQVENLTSTLEHTSY 587
            :::|.....|....|....|:..| .|||                |.|||:    :.:..|..:|
  Rat   874 IDYFKSLGQYLHSGPPVYFVLEEG-YNYSSRRGQNMVCGGMGCDNDSLVQQ----IFNAAELDTY 933

  Fly   588 VTSRRYTESWLRSFLSFLERNN---ELLNVTVDDEQTFIDAV----------------------K 627
            ........||:..:..::...:   .|.|||    ..|.:|.                      |
  Rat   934 TRVGFAPSSWIDDYFDWVSPQSSCCRLYNVT----HQFCNASVIDPTCVRCRPLTPEGKQRPQGK 994

  Fly   628 EHWLF-----PGNP-----------FSLDVRFNEDETQIIASRFL-------------------- 656
            |...|     ..||           :|..|....|:|.|.|:.|:
  Rat   995 EFMKFLPMFLSDNPNPKCGKGGHAAYSSAVNIMGDDTYIGATYFMTYHTILKTSADYIDALKKAR 1059

  Fly   657 IQAVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIIS 721
            :.|.|||:|...           |.|......:..::||::|:        ..::..||..:.:|
  Rat  1060 LIASNITETMRS-----------KGSDYRVFPYSVFYVFYEQY--------LTIIDDAIFNLSVS 1105

  Fly   722 F--VFIPNIL---CSLWVA----FSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAH 777
            .  :|:..::   |.||.|    .::..|.:.:.|.|.||.::|:::|::||:|..|.||:|.:|
  Rat  1106 LGSIFLVTLVALGCELWSAVIMCLTIAMILVNMFGVMWLWGISLNAVSLVNLVMTCGISVEFCSH 1170

  Fly   778 ICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTIL-GIVALLLAQSYIFLVF-FKMVFLVIFF 840
            |...:..|.|.|..:|..|||..:|..:..|.:.|.. |||.|..|:|.||.:| |:|...::..
  Rat  1171 ITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLL 1235

  Fly   841 GAMHGLFLLPVLLSLFGP 858
            ||.|||..||||||..||
  Rat  1236 GATHGLIFLPVLLSYIGP 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	204/934 (22%)
Npc1	NP_705888.2	2A060601	26..1252	CDD:273337	221/990 (22%)