Protein Alignment Ptr and Npc1

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_032746.2
• Gene: Npc1 / 18145
• MGIID: 1097712
• Length: 1277
• Species: Mus musculus
• Alignment Length: 986
• Identity: 220/986 - (22%)
• Similarity: 398/986 - (40%)
• Gaps: 201/986 - (20%)

  Fly     9 DKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVE 73
            |..|.:.|...|....::|...|...:....:|.:|...::...:|..|:|....:.:.|:
Mouse   332 DDCLRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEK---- 392

  Fly    74 QYFKVNYTHRFNVGR--ITRPGRFGRVIVITKDGDE----NMIRREVFQELRQLDNIIQNATTTY 132
            :||..::...|...:  |..|.....:......|.:    ..:.:|:..::..|...|::.|.:|
Mouse   393 EYFDKHFGPFFRTEQLIIQAPNTSVHIYEPYPAGADVPFGPPLNKEILHQVLDLQIAIESITASY 457

  Fly   133 DGDTYTYKDNC----ARWENEC--------FENDILNLDALMDD---------------IEA-GQ 169
            :.:|.|.:|.|    :.:...|        |:|....||:.:.|               :.| ..
Mouse   458 NNETVTLQDICVAPLSPYNKNCTIMSVLNYFQNSHAVLDSQVGDDFYIYADYHTHFLYCVRAPAS 522

  Fly   170 LNLTFPFMFNPV--TWDAHLFP-VFFGGTKLTEDNY------VISVPAIQLVYFVTADTKRQDAK 225
            ||.| ..:..|.  |:...:|| :..||  ..:.||      ||:.|...  |:  .||:|....
Mouse   523 LNDT-SLLHGPCLGTFGGPVFPWLVLGG--YDDQNYNNATALVITFPVNN--YY--NDTERLQRA 580

  Fly   226 GAEWEETFLRVVGNAENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCM 290
            .| ||:.|:..|.|.:|    .::::|:.|.|:::.||.:.:.:.|  |:.....:.:|..|:..
Mouse   581 WA-WEKEFISFVKNYKN----PNLTISFTAERSIEDELNRESNSDV--FTVIISYVVMFLYISLA 638

  Fly   291 MGD-------AVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINL-AAPFLMIGIGIDDTF 347
            :|.       .|.||..||:.|.:..:.:...:.|:..|.|:....|.: ..|||::.:|:|:.|
Mouse   639 LGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIF 703

  Fly   348 VMLAGWRRTK--AKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAV 410
            :::..::|.:  .:..:.:::|.::.|.|.::.::|.::..:|..|.:|...:|..|..::..||
Mouse   704 ILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAV 768

  Fly   411 CFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSVAIKEKRNFLYKAIMAGGIDANDPDNP 475
            ...||..||.|.:.:.:...|:.||...|..|                        :...|....
Mouse   769 LIDFLLQITCFVSLLGLDIKRQEKNHLDILCC------------------------VRGADDGQG 809

  Fly   476 IDNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVE 540
            ....:..|..|||:..|.::...|.:.|::..|...|..:...:.::..||::......|||.::
Mouse   810 SHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVID 874

  Fly   541 FFDREDDYYREFPYRMQVIIAGPLNYS----------------DPLVQEQVENLTSTLEHTSYVT 589
            :|.....|....|....|:..| .|||                |.|||:    :.:..|..:|..
Mouse   875 YFKSLAQYLHSGPPVYFVLEEG-YNYSSRKGQNMVCGGMGCDNDSLVQQ----IFNAAELDTYTR 934

  Fly   590 SRRYTESWLRSFLSFLERNN---ELLNVTVDDEQTFIDAV----------------------KEH 629
            ......||:..:..::...:   .|.|||    ..|.:|.                      ||.
Mouse   935 VGFAPSSWIDDYFDWVSPQSSCCRLYNVT----HQFCNASVMDPTCVRCRPLTPEGKQRPQGKEF 995

  Fly   630 WLF-----PGNP-----------FSLDVRFNEDETQIIASRFL--------------------IQ 658
            ..|     ..||           :...|....|:|.|.|:.|:                    :.
Mouse   996 MKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTILKTSADYTDAMKKARLI 1060

  Fly   659 AVNITDTNHEKEMVRDLRQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFV 723
            |.|||:|...           |.|......:..::||::|:..:...::..:.:....:.:::.|
Mouse  1061 ASNITETMRS-----------KGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLV 1114

  Fly   724 FIPNILCSLWVA----FSVISIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMS 784
            .:.   |.||.|    .::..|.:.:.|.|.||.::|:::|::||:|..|.||:|.:||...:..
Mouse  1115 VLG---CELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTM 1176

  Fly   785 SKKRSPKARVREALHSLGLPIIQGSSSTIL-GIVALLLAQSYIFLVF-FKMVFLVIFFGAMHGLF 847
            |.|.|..:|..|||..:|..:..|.:.|.. |||.|..|:|.||.:| |:|...::..||.|||.
Mouse  1177 STKGSRVSRAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLI 1241

  Fly   848 LLPVLLSLFGP 858
            .||||||..||
Mouse  1242 FLPVLLSYIGP 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	201/927 (22%)
Npc1	NP_032746.2	2A060601	25..1251	CDD:273337	218/983 (22%)
		Important for cholesterol binding and cholesterol transfer from NPC1 to liposomes. /evidence=ECO:0000250	175..205
		Di-leucine motif. /evidence=ECO:0000305	1274..1277
		Required for location in lysosomes. /evidence=ECO:0000250|UniProtKB:O15118	1274..1277