Protein Alignment Ptr and ptr-2

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_491221.1
• Gene: ptr-2 / 171950
• WormBaseID: WBGene00004217
• Length: 933
• Species: Caenorhabditis elegans
• Alignment Length: 881
• Identity: 273/881 - (30%)
• Similarity: 459/881 - (52%)
• Gaps: 48/881 - (5%)

  Fly     7 CVDKTLNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAI 71
            ||::.....|..||..|..||..|.:.|:|.|.....|...|....|..|||:|:..:.|.||..
 Worm     5 CVERRAASLFRQLGFLICDHPLPFFVFPLLFTAAMGVGLLHLNPLSDAVYLFTPLGAQSKMERMS 69

  Fly    72 VEQYFKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQ-NATTTYDGD 135
            :.:.:.:. .:.:..||.....|..:|..:.:: |.|::..:....:.|||..|| .....::|.
 Worm    70 IHEKWPLT-DNNYIPGRAVTQSREIQVTALARN-DSNILDPKFANAVYQLDKYIQTRVRVLHNGH 132

  Fly   136 TYTYKDNCARWEN-ECFENDILNLDALMDDIEAGQLNLTFP-FMFNPVTWDAHLFPVFFGGTKL- 197
            .|:||:.|.:::| .|..|..::   ::.|:.....|:|:| |.|..   :........||..:
 Worm   133 YYSYKNLCLQYKNGGCPSNKHVH---ILSDLHNHGFNITYPYFRFGS---EGGYIGSSLGGVTVM 191

  Fly   198 ---TEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLRVVGNAENSGQFKHISVSYFASRTL 259
               .|.:.:.|..|..::|.:....:.......|||....|::......   .:||::||.|:||
 Worm   192 KGENETDILASAKAWFMIYHLKFHPEEMSYISGEWELELGRMLTQYPED---PYISITYFHSQTL 253

  Fly   260 DHELEKNTKTVVPYFSSTFLLMGLFSIITCMMG--------DAVRSKPFLGLMGNVSAIMATLAA 316
            ..||::|..|::|.|..:..|:.:||.: |.:.        |.|.|||.|.::|.|||.:|.|..
 Worm   254 ADELKRNADTLIPRFIISITLLIVFSTL-CSLSFIDGSFSIDWVLSKPILSILGVVSAGIAILTG 317

  Fly   317 FGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITS 381
            .|.....|:.:..|....|||::.:|:|:.|:|:|..|||.....|.||||..:::|||||.|||
 Worm   318 VGFLSLMGMPYNDIVGVMPFLVLAVGVDNMFLMVAAVRRTSRTHTVHERMGECLADAAVSILITS 382

  Fly   382 VTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQP 446
            .||.:||.:|.|:...:|:|||.|:..|:.|.|::.|||||||:|::...|....:|:|  .::.
 Worm   383 STDVLSFGVGAITTIPAVQIFCVYTGVAIFFAFIYQITFFAACLALAMKHEASGRNSLF--LIEA 445

  Fly   447 MSVAIKEKRNFLYKAIMAGGIDANDPDNPI--DNKDHMLMAFFKDKMAAVINNKWCKAIIILAFA 509
            :|...|...:...:....|.:    ||:..  |.|..:...||.:..|.|:.:...:.|.::.|.
 Worm   446 VSAEKKTSLSTFQRLFNLGSV----PDHSASHDVKQPLTSRFFGEWYAPVLMHPVVRGIAMVWFV 506

  Fly   510 SYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAGPLNYSDPLVQEQ 574
            .||:||.||.::||||||...|..||||::..:...:.|:.::..::|::|....:..:...:::
 Worm   507 IYLLGASYGCSRIKEGLEPVNLLVEDSYAIPHYRLLEKYFWKYGQQVQIVINNAPDLRNHTSRDR 571

  Fly   575 VENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVKEHWLF--PGNPF 637
            |..:......:.:.......:.||.....:.::.   |.|.:.|...:  .:..|:|.  ..||.
 Worm   572 VHAMVLDFATSKHAIGMESVQFWLFEMERYYQKE---LEVQIIDSSFY--GLLHHFLASKTNNPL 631

  Fly   638 SLDVRF-----NEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKDSP-LNASIFHPYFVFF 696
            :.|:.:     :::.|.:.:.||::...::..|..:.:.....|::....| .|.:.|.|.::|.
 Worm   632 AEDIYWGPMPDDDNGTMVKSFRFILGMKDLVTTMDQTDATMSFREVAARWPEFNVTTFMPIWMFT 696

  Fly   697 DQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDSISM 761
            ||:.::.|.::|.::|..::|::|:.:|||..:||||||.:..||:.||.|||.||.||||:|||
 Worm   697 DQYIIIIPNTVQNIIIALLVMIVIAVLFIPQPMCSLWVALACASIDFGVIGYMTLWGVNLDAISM 761

  Fly   762 INLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYI 826
            |.:||.||||||::|||.|.|:.|::.:...||:|||.:||.|:.||:.|||:.:..|....:|:
 Worm   762 ITIIMSIGFSVDYSAHIAYGYVVSREDTAAGRVKEALSALGWPLSQGAMSTIIAVSVLADIPAYM 826

  Fly   827 FLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGPGSCL 862
            .:.|||.|.|.|..|.:|||..||||||:|..|.|:
 Worm   827 IVTFFKTVVLSISLGLLHGLVFLPVLLSIFVRGCCI 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	247/816 (30%)
ptr-2	NP_491221.1	Patched	47..858	CDD:308203	257/833 (31%)