Protein Alignment Ptr and ptr-12

DIOPT Version :10

• Sequence 1: NP_610209.2
• Gene: Ptr / 35546
• FlyBaseID: FBgn0262867
• Length: 1169
• Species: Drosophila melanogaster
• Sequence 2: NP_001021559.2
• Gene: ptr-12 / 171816
• WormBaseID: WBGene00004226
• Length: 901
• Species: Caenorhabditis elegans
• Alignment Length: 901
• Identity: 209/901 - (23%)
• Similarity: 387/901 - (42%)
• Gaps: 121/901 - (13%)

  Fly    23 IAKHPGYFIIIPVLLTLL------------CMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQY 75
            :|.|....|:|.|:|||:            .:|||             :|.....:.|..::..:
 Worm    37 VADHAVALIVICVVLTLIGTFKVATTPNDNDITGY-------------TPYGARARDEFDVMTDF 88

  Fly    76 FKVNYTHRFNVGRITRPGRFGRVIVITKDGDENMIRREVFQELRQLDNIIQN--ATTTYDGDTYT 138
            |    .|..|        .....::|.....|:::..:|.:|..:|::|:..  :..:.||....
 Worm    89 F----AHNGN--------GIAMFVLILPTRHESVLHPDVLREALRLEDILSTNFSMLSADGKPEN 141

  Fly   139 YKDNCARW--ENECFENDILNLDALMDDIEAG-----QLNLTFPFMFNPVTWDAHLFPVFFGGTK 196
            |::.|..:  .||.|.....:....:|:.:.|     :::|.:| :.:..:....:.|.|||...
 Worm   142 YQEFCTNFCQINEPFVQFARSYLTELDNSKNGTDLSERISLNYP-ITSIYSRKMSIQPNFFGIEM 205

  Fly   197 LTEDNYVISVPAIQLVYFVTADTKRQDAKGAEWEETFLR-----VVGNAENSGQFKHISVSYFAS 256
            :.|...  |:..|:....:....:.:..:|  |....::     :....|...:...|.|...::
 Worm   206 MNETKK--SITNIRSSKLIALQLRSERKEG--WNSNGIKDFEMSITNYLEKEFESPEIRVLTLST 266

  Fly   257 RTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCM-----MGDAVRSKPFLGLMGNVSAIMATLAA 316
            ..::.|:.:...:::|:....|::|.:.|.:|..     |......|..|.:...:...||...|
 Worm   267 SYVEAEVVRAGMSLLPFLIVGFVIMAIVSSVTTFFSAVYMQQVSIHKFSLAIAACICPFMACGTA 331

  Fly   317 FGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKA---KMPVA-ERMGLMMSEAAV-- 375
            .|...:||:.|..|....|||::.||:||.::|:..|:|..|   |.||| :..|..:||..|
 Worm   332 LGALFFCGVRFGSILCVTPFLVLAIGVDDAYLMIHSWQRVTAERRKHPVANDSPGSRLSEVLVDT 396

  Fly   376 --SITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHS 438
              :|.|:::|:..:.:.|..:....:.:....::..:...||:.|||::|.|.::||.|.|:
 Worm   397 GPAILISALTNIFADVAGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTLTGYFEMKD--- 458

  Fly   439 IFGCRVQPMSVAIKEKRNFLYKAIMAGGIDAND---PDNPIDNKDHML---MAFFKDKMAAVINN 497
                         :|::..:.|  :|.|.|::|   ..:.:::.|.::   :..|.:...::|.|
 Worm   459 -------------EEQKRHIKK--IACGADSDDSSCTSSSVESFDVIVKRRVTSFLENYISLITN 508

  Fly   498 KWCKAIIILAFASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYREFPYRMQVIIAG 562
            .:.:..::|.:.::||.:.||||.:...|..|||..|||...|..|....|.....|...|.:..
 Worm   509 AFFQIFVVLVWIAFLVVSIYGITIMNINLSPRKLFMEDSSLREMDDLRVKYVIPNFYLANVFVRK 573

  Fly   563 PLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSFLSFLERNNELLNVTVDDEQTFIDAVK 627
            |.:.:|....:::......:||.:.......|..::|.|::|.....|.......:|:..|  ||
 Worm   574 PGDLTDGARLQRLNQFVEEMEHLNGSWGSLGTNYFVRDFVNFQAAMVEEEEAEGGEEEASI--VK 636

  Fly   628 EHWLFPGN-PFSLD----------VRFNEDETQIIASRFL----IQAVNITDTNHEKEMVRDLRQ 677
            ...:...| |..|:          |:|:..|.:.:..||.    |...|:.......:.:|:.|.
 Worm   637 RGGIDVNNLPMFLEWPEYLFWKGFVQFHSAENRTVLDRFFITFAIHGTNLQSWPARGDALREWRN 701

  Fly   678 ICK--DSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVF---IPNILCSLWVAFS 737
            :..  .:....|:|....::.|..|.:...:.|:.|.....|..|.|||   :|.::    ||.|
 Worm   702 VVDKYSAEFGLSVFSDDGIYVDLIENMPTDAWQSAVATLACMAFICFVFMYDVPTVM----VATS 762

  Fly   738 VI-SIELGVAGYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSS-KKRSPKARVREALHS 800
            :| ||..|:.|.::|...:||.|.|..||:.||||||..|||.|.|.:| .....:.|:.:.|.|
 Worm   763 IIASIMTGILGILSLTGTDLDPIVMSALIISIGFSVDIPAHISYHYHTSPSDNGIRHRLHKTLSS 827

  Fly   801 LGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLF 856
            :|.|.:|.:.||.|.:::|..:..|:...|.|.:...:.....|.|.|||.|.::|
 Worm   828 VGFPALQATVSTSLCVLSLKFSSIYMSCAFVKTMITCMILCVFHALVLLPCLFAIF 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptr	NP_610209.2	Patched	53..845	CDD:308203	191/846 (23%)
ptr-12	NP_001021559.2	Patched	66..883	CDD:308203	200/870 (23%)