Protein Alignment EcR and thrab

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: XP_009304995.1
• Gene: thrab / 558427
• ZFINID: ZDB-GENE-060613-1
• Length: 419
• Species: Danio rerio
• Alignment Length: 472
• Identity: 141/472 - (29%)
• Similarity: 221/472 - (46%)
• Gaps: 88/472 - (18%)

  Fly   212 MQHTPRSDSVNSISSGRDDLSPSSSLNG---YSANESCDAKKSKKG-----------PAPRVQEE 262
            |:|.|:....|. |.|.:    ...|:|   ...|..|..|.....           |:...::|
Zfish     1 MEHMPKEQDPNQ-SEGEE----KRWLDGPKRKRKNSQCSVKSMSVSSTSNPISQGYIPSYLEKDE 60

  Fly   263 LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKS--AVYCCKFGRACEMDMYMRRKCQECRLKKCL 325
            .|:||||:|:||||..:|||||||||||::.|:  ..|.||:...|.:|...|.:||.||.|||:
Zfish    61 PCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYDGCCIIDKITRNQCQLCRFKKCI 125

  Fly   326 AVGMRPECVVPENQCAMKRR---EKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLM 387
            ||||..:.|:.:::...|||   |.:.:::|::|..:..::.....|          :.|::.::
Zfish   126 AVGMAMDLVLDDSKRVAKRRLIEENREKRKKEEMVKTLQNRPEPTSS----------EWELIRVV 180

  Fly   388 TCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPDEN 452
            | |..:|           ...|..:                |.|.....|  ||:.:....|..:
Zfish   181 T-EAHRH-----------TNAQGSH----------------WKQKRKFLP--EDIGQSPVAPTSD 215

  Fly   453 ESQTDV-SFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSS 516
            ..:.|: :|...|:|....:..:|:|||.||.|:::|.||||.|||.|..|:|.||.|.|||..|
Zfish   216 GDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPES 280

  Fly   517 DSIFFANNRSYTRDSYKMAGM---ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIF-SDRPGLE 577
            :::..:...:..|:..|..|:   :|.|.||   .:.:....:|:.|.|||.|:::. |||.||.
Zfish   281 ETLTLSGEMAVKREQLKNGGLGVVSDAIFDL---GKSLAQFNLDDTEVALLQAVLLMSSDRTGLT 342

  Fly   578 KAQLVEAIQSYYIDTLRIYILNR-----HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            ..:.:|..|..|:.....||..|     |        |:.|||..:|:||.:|..:|.....:|:
Zfish   343 CVEKIEKCQEMYLLAFEHYINYRKHNIPH--------FWPKLLMKVTDLRMIGACHASRFLHMKV 399

  Fly   638 K-NRKL--PKFLEEIWD 651
            : ..:|  |.|||...|
Zfish   400 ECPTELFPPLFLEVFED 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	45/94 (48%)
		NR_LBD_EcR	420..652	CDD:132736	76/245 (31%)
thrab	XP_009304995.1	NR_DBD_TR	61..147	CDD:143519	43/85 (51%)
		NR_LBD_TR	171..413	CDD:132733	80/292 (27%)