DRSC/TRiP Functional Genomics Resources

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Protein Alignment EcR and PPARG

DIOPT Version :10

Sequence 1:NP_724460.1 Gene:EcR / 35540 FlyBaseID:FBgn0000546 Length:878 Species:Drosophila melanogaster
Sequence 2:NP_056953.2 Gene:PPARG / 5468 HGNCID:9236 Length:505 Species:Homo sapiens


Alignment Length:428 Identity:117/428 - (27%)
Similarity:184/428 - (42%) Gaps:78/428 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   250 KSKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVY-CCKFGRACEMDMYMR 313
            |..:.|:..:....|.||||:|||:||....||||||||||::....:| .|...  |.:....|
Human   125 KPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN--CRIHKKSR 187

  Fly   314 RKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDF 378
            .|||.||.:|||||||....:         |..:..|.||:|:....||.            .|.
Human   188 NKCQYCRFQKCLAVGMSHNAI---------RFGRMPQAEKEKLLAEISSD------------IDQ 231

  Fly   379 VKKEILDLMTCEPPQHATIPLLPDEILAKCQARNI--PSLTYNQLAVIYKLIWYQDGYEQPSEED 441
            :..|..||...  .:|.....:....|.|.:||.|  ...|.....|||               |
Human   232 LNPESADLRAL--AKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY---------------D 279

  Fly   442 LRRIMSQPDENESQTDVSFRHITEI------------------TILTVQLIVEFAKGLPAFTKIP 488
            :..:|...|:      :.|:|||.:                  ::..||.|.|:||.:|.|..:.
Human   280 MNSLMMGEDK------IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD 338

  Fly   489 QEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSY-TRDSYK--MAGMADNIEDLLHFCRQ 550
            ..||:||||....|::...:|...  :.|.:..:..:.: ||:..|  .....|.:|....|..:
Human   339 LNDQVTLLKYGVHEIIYTMLASLM--NKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVK 401

  Fly   551 MFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKL 614
            ..::::|:.:.|:..|::|.| |||||...:.:|.||...:..|.:.:...|...|.   .:|||
Human   402 FNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQ---LFAKL 463

  Fly   615 LSILTELRTLGNQNAEMCFSLKL--KNRKLPKFLEEIW 650
            |..:|:||.:..::.::...:|.  .:..|...|:||:
Human   464 LQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIY 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EcRNP_724460.1 NR_DBD_EcR 261..351 CDD:143535 37/90 (41%)
NR_LBD_EcR 420..652 CDD:132736 61/255 (24%)
PPARGNP_056953.2 PPARgamma_N 31..108 CDD:463633
NR_DBD_Ppar 138..221 CDD:143523 40/93 (43%)
Interaction with FAM120B. /evidence=ECO:0000250 205..280 21/112 (19%)
NR_LBD_PPAR 237..504 CDD:132730 70/293 (24%)
9aaTAD. /evidence=ECO:0000269|PubMed:30468856 495..503 3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

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