Protein Alignment EcR and PPARD

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_006229.1
• Gene: PPARD / 5467
• HGNCID: 9235
• Length: 441
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 131/459 - (28%)
• Similarity: 203/459 - (44%)
• Gaps: 72/459 - (15%)

  Fly   211 GMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDRASGYH 275
            |.||...|.|...:|...   ||.|.|:  .....||      |.:.......|.||||:|||:|
Human    32 GPQHALPSSSYTDLSRSS---SPPSLLD--QLQMGCD------GASCGSLNMECRVCGDKASGFH 85

  Fly   276 YNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQC 340
            |....||||||||||::.....| .|..|:|::....|.|||.||.:||||:||....:
Human    86 YGVHACEGCKGFFRRTIRMKLEY-EKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAI------ 143

  Fly   341 AMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEIL 405
               |..:..:.||.|:..         |..|:.|.|  ...::.||....  :|.....|.:..:
Human   144 ---RFGRMPEAEKRKLVA---------GLTANEGSQ--YNPQVADLKAFS--KHIYNAYLKNFNM 192

  Fly   406 AKCQARNI--------PSLTYNQLAVIYK----LIWYQDGYEQPSEEDLRRIMSQPDENESQTDV 458
            .|.:||:|        .....:.:..:::    |:|.|            .:...|...|....|
Human   193 TKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQ------------LVNGLPPYKEISVHV 245

  Fly   459 SFR-HITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFA 522
            .:| ..|  |:.||:.:.||||.:|:|:.:...||:||||....|.:...:|...  :.|.:..|
Human   246 FYRCQCT--TVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIV--NKDGLLVA 306

  Fly   523 NNRSY-TRDSYK--MAGMADNIEDLLHFCRQMFSMKVDNVEYAL-LTAIVIFSDRPGLEKAQLVE 583
            |...: ||:..:  ....:|.||....|..:..::::|:.:.|| :.||::..|||||.....||
Human   307 NGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVE 371

  Fly   584 AIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRK--LPKFL 646
            |||...:..|..::...| .|:..|  :.|||..:.:||.|..::|:|...:|....:  |...|
Human   372 AIQDTILRALEFHLQANH-PDAQYL--FPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLL 433

  Fly   647 EEIW 650
            :||:
Human   434 QEIY 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	37/89 (42%)
		NR_LBD_EcR	420..652	CDD:132736	66/242 (27%)
PPARD	NP_006229.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		8/24 (33%)
		NR_DBD_Ppar	73..156	CDD:143523	39/92 (42%)
		NR_LBD_PPAR	173..440	CDD:132730	74/286 (26%)