Protein Alignment EcR and PPARA

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_005027.2
• Gene: PPARA / 5465
• HGNCID: 9232
• Length: 468
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 133/538 - (24%)
• Similarity: 227/538 - (42%)
• Gaps: 106/538 - (19%)

  Fly   145 LINSTTPSTPTTPLH---LQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGG 206
            ::::.:|..|.:||.   |:..|.                    ...:..:|....:...:|...
Human     1 MVDTESPLCPLSPLEAGDLESPLS--------------------EEFLQEMGNIQEISQSIGEDS 45

  Fly   207 VGGLG------MQHTPRSDSVNSISSGRDDLSPSSSLNGY-------SANESCDAKKSKKGPAPR 258
            .|..|      :...|.||.    |...|.|||:||.:..       |.:||         |:..
Human    46 SGSFGFTEYQYLGSCPGSDG----SVITDTLSPASSPSSVTYPVVPGSVDES---------PSGA 97

  Fly   259 VQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKK 323
            :..| |.:|||:||||||....||||||||||::....|| .|..|:|::....|.|||.||..|
Human    98 LNIE-CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVY-DKCDRSCKIQKKNRNKCQYCRFHK 160

  Fly   324 CLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMT 388
            ||:|||....:    :.....|.:||:.:.:.:|.....:......|.|      :.|.|.:...
Human   161 CLSVGMSHNAI----RFGRMPRSEKAKLKAEILTCEHDIEDSETADLKS------LAKRIYEAYL 215

  Fly   389 CEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDL-RRIMSQPDEN 452
                ::..:..:...::...:|.|.|....:.:..:..           :|:.| .::::...:|
Human   216 ----KNFNMNKVKARVILSGKASNNPPFVIHDMETLCM-----------AEKTLVAKLVANGIQN 265

  Fly   453 ESQTDVSFRHITEIT-ILTVQLIVEFAKGLPAFTKIPQEDQITLLK--------ACSSEVMMLRM 508
            : :.:|...|..:.| :.||..:.||||.:|.|..:...||:||||        |..|.||
Human   266 K-EAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVM---- 325

  Fly   509 ARRYDHSSDSIFFA-NNRSYTRDSYK--MAGMADNIEDLLHFCRQMFSMKVDNVEYAL-LTAIVI 569
                  :.|.:..| .|...||:..|  .....|.:|....|..:..::::|:.:.:| :.||:.
Human   326 ------NKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIIC 384

  Fly   570 FSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFS 634
            ..|||||.....:|.:|...:..||:::.:.|..|   :..:.|||..:.:||.|..::|::...
Human   385 CGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDD---IFLFPKLLQKMADLRQLVTEHAQLVQI 446

  Fly   635 LKL--KNRKLPKFLEEIW 650
            :|.  .:..|...|:||:
Human   447 IKKTESDAALHPLLQEIY 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	41/89 (46%)
		NR_LBD_EcR	420..652	CDD:132736	60/247 (24%)
PPARA	NP_005027.2	NR_DBD_Ppar	101..184	CDD:143523	41/88 (47%)
		NR_LBD_PPAR	201..467	CDD:132730	67/299 (22%)
		Required for heterodimerization with RXRA	304..433		37/141 (26%)