Protein Alignment EcR and nr1h4

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001002574.1
• Gene: nr1h4 / 436847
• ZFINID: ZDB-GENE-040718-313
• Length: 483
• Species: Danio rerio
• Alignment Length: 477
• Identity: 169/477 - (35%)
• Similarity: 240/477 - (50%)
• Gaps: 87/477 - (18%)

  Fly   212 MQHTPRSDSVNSIS-----------SGRDDLSPSS-------SLNGYSAN---ESCD-----AKK 250
            ||:|....|::|.|           ...:..|||:       .|:|...|   |||.     .|:
Zfish    57 MQYTSVEPSMSSPSYYSSQHCYSQYGAEEWYSPSAMFEMRKGPLDGGFDNELDESCPVIPTVCKR 121

  Fly   251 SK--------KGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACE 307
            |:        ||      ||||:||||:|||||||||||||||.|||||:||:|||.||.|..||
Zfish   122 SRHAGHSGKSKG------EELCVVCGDKASGYHYNALTCEGCKVFFRRSITKNAVYKCKSGGNCE 180

  Fly   308 MDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLAS 372
            ||||||||||||||:||..:||..||::.|.||..||..|..:...|             ||:
Zfish   181 MDMYMRRKCQECRLRKCKEMGMLAECLLTEIQCKSKRLRKNTKASSD-------------GSI-- 230

  Fly   373 GGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQP 437
              |.|.|...       :|.|..:        ..|....|| .|:.:|.|:|..::...:.:..|
Zfish   231 --GDDVVDSR-------DPKQVVS--------TTKPSKENI-ELSQDQQALINYIVDAHNKHRIP 277

  Fly   438 SEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSE 502
              :|:.:.:.|...|..:   :|..:||:....||::|||.|.:|.|..:..||||.|||..:.|
Zfish   278 --QDMAKKLLQEQFNAEE---NFLLLTEMATSHVQVLVEFTKNIPGFQSLDHEDQIALLKGSAVE 337

  Fly   503 VMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADN-IEDLLHFCRQMFSMKVDNVEYALLTA 566
            .|.||.|:.:.....:    .:.....|..:.:|:::. |..:.:|.:.:..:::...|:|||||
Zfish   338 AMFLRSAQVFSKKLPN----GHTEVLEDRIRRSGISEEFITPMFNFYKSIGELQMMQEEHALLTA 398

  Fly   567 IVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAE 630
            |.|.| |||.::..|.||.:|...::.||.....:|..:..   .:|:||..|||||||.:.:||
Zfish   399 ITILSPDRPYVKDQQAVERLQEPMLEVLRKICKLQHPQEPQ---HFARLLGRLTELRTLNHHHAE 460

  Fly   631 MCFSLKLKNRKLPKFLEEIWDV 652
            |..|.::.:.|....|.|||||
Zfish   461 MLESWRMSDHKFNPLLCEIWDV 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	64/89 (72%)
		NR_LBD_EcR	420..652	CDD:132736	72/233 (31%)
nr1h4	NP_001002574.1	NR_DBD_FXR	134..217	CDD:143520	61/82 (74%)
		NR_LBD_Fxr	258..478	CDD:132734	69/231 (30%)