Protein Alignment EcR and Rorc

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001414201.1
• Gene: Rorc / 368158
• RGDID: 1595785
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 137/531 - (25%)
• Similarity: 221/531 - (41%)
• Gaps: 146/531 - (27%)

  Fly   251 SKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRK 315
            :||....:::...|.:|||::||.||..:||||||||||||...:..|.|...:.|.:|...|.:
  Rat    18 AKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNR 82

  Fly   316 CQECRLKKCLAVGMRPECVVPENQCAMKRR-------EKKAQKEKDK---MTTSPSSQHGG---- 366
            ||.|||:||||:||..: .|...:.:.|:|       :|:.|:::.:   ..|.|:..||.
  Rat    83 CQHCRLQKCLALGMSRD-AVKFGRMSKKQRDSLHAEVQKQLQQQQQREQVAKTPPAGSHGADTLT 146

  Fly   367 ------NGSL--------------------ASGGGQDF----VKKEI------------------ 383
                  :|.|                    |||.|..:    .|.|:
  Rat   147 YTLGVPDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEG 211

  Fly   384 ---------------LDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIW---- 429
                           ..|...||.|.:.....|    :.|.|   |...|..|..|..|:.
  Rat   212 RDSIYSTDGQLTLGRRGLQLGEPEQGSDSHCSP----SFCSA---PEAPYASLTDIEYLVQNVCK 269

  Fly   430 -YQDGYEQPSEEDLRR---IMSQPD----ENESQTDVSFR---HITEITILTVQLIVEFAKGLPA 483
             |::..:...|:.||:   :.|:.:    :.:|..::..|   |:||    .:|.:|||||.|..
  Rat   270 SYRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTE----AIQYVVEFAKRLSG 330

  Fly   484 FTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFC 548
            |.::.|.|||.||||.:.||:::||.|.|:.::.::||....... :.::..|.::.|..:..|.
  Rat   331 FMELCQNDQIILLKAGAMEVVLVRMCRAYNANNHTVFFEGKYGGV-ELFRALGCSELISSIFDFS 394

  Fly   549 RQMFSMKVDNVEYALLTAIVIF-SDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYA 612
            ..:.::.....|.||.||:|:. ::||||::.:.||.:|.                 ::.|.|:.
  Rat   395 HFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQY-----------------NLELAFHH 442

  Fly   613 KL-----------LSILTELRTLGNQNAEMCFSLKLKNRKLPKF--LEEIWDVHAIPPSVQSHLQ 664
            .|           |....:||:|.:|:.|          ||..|  |..|....|.||..:....
  Rat   443 HLCKTHRQGLLAKLPPKGKLRSLCSQHVE----------KLQDFQHLHPIVVQAAFPPLYKELFS 497

  Fly   665 ITQEENERLER 675
            ...|.:|.|.:
  Rat   498 TDIESSEGLSK 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	40/96 (42%)
		NR_LBD_EcR	420..652	CDD:132736	67/260 (26%)
Rorc	NP_001414201.1	None