Protein Alignment EcR and nhr-140

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_504768.1
• Gene: nhr-140 / 3565647
• WormBaseID: WBGene00016366
• Length: 346
• Species: Caenorhabditis elegans
• Alignment Length: 382
• Identity: 79/382 - (20%)
• Similarity: 130/382 - (34%)
• Gaps: 106/382 - (27%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVT--KSAVYCCKFGRACEMDMYMRRKCQECRLKKCLA 326
            |.|||.::|..|:..|:|..|..||||.|.  |..:.|     .|.........|:.||:.||:.
 Worm     3 CGVCGAKSSESHFGGLSCRACAAFFRRYVNSKKPQIEC-----TCSQKFDSSGPCRYCRMLKCVE 62

  Fly   327 VGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEP 391
            ||| .:|.|            :|.::|:                          ||.:.|    |
 Worm    63 VGM-AKCKV------------QATRQKN--------------------------KEYVFL----P 84

  Fly   392 PQHATIPLLPDEILAK------CQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPD 450
            .....|.||...|:.:      |..:|.|.|. .:...:|....|...:.|.|    .|:
 Worm    85 CAITNISLLSCNIIPRSCSKLTCTVKNWPDLD-KKRRDLYGGSMYNLNFTQFS----NRV----- 139

  Fly   451 ENESQT---DVSFRHITEITILT-----------------VQLIVEFAKGLPAFTKIPQEDQITL 495
             .:..|   |::....:||.:|.                 ::..:|:.|......|:.:.|.:..
 Worm   140 -RQDTTIFWDLAESIFSEIGLLNSDDKDALLCNFFPRWMLMEAAIEYCKNYEHHWKMIETDGLDN 203

  Fly   496 LKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVE 560
            :........|.:..|..|.....||    |.|....|            :.....:...|.|.||
 Worm   204 MLLVFYGSSMPKEKRLDDDKIIQIF----RPYWTRFY------------IEIAEPIHQEKCDKVE 252

  Fly   561 YALLTAIVIFSD---RPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKL 614
            :..|..:::|.|   ....|.|:|...:|...:..|:.|.::.:|.:...:...:||
 Worm   253 FMALFLLILFDDAYLNISEEAAKLCRNLQKVILRELKGYQMDNNCSEMRFMDVISKL 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	28/88 (32%)
		NR_LBD_EcR	420..652	CDD:132736	38/218 (17%)
nhr-140	NP_504768.1	ZnF_C4	3..65	CDD:197701	23/66 (35%)
		Hormone_recep	152..314	CDD:459675	31/174 (18%)