Protein Alignment EcR and Nr1d2

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001412823.1
• Gene: Nr1d2 / 353187
• MGIID: 2449205
• Length: 586
• Species: Mus musculus
• Alignment Length: 571
• Identity: 145/571 - (25%)
• Similarity: 227/571 - (39%)
• Gaps: 183/571 - (32%)

  Fly   219 DSVNSISSGRDDLSPSSSLNGYSANESCDAK-KSKKGPAPRVQEE-------------------- 262
            :|.|..::|....:..||::|...::..|.. |:.|..||.:.:.
Mouse    45 NSSNCDANGNPKNADISSIDGVLKSDRTDCPVKTGKTSAPGMTKSHSGMTTFYFLSPYALEFSGM 109

  Fly   263 --LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVY--CCKFGRACEMDMYMRRKCQECRLKK 323
              ||.||||.|||:||....|||||||||||:.::..|  |.| ...|.:....|.:||:||.||
Mouse   110 VLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLK-NENCSIMRMNRNRCQQCRFKK 173

  Fly   324 CLAVGMRPECV----VP---------ENQCAMK-----------------------------RRE 346
            ||:|||..:.|    :|         |.|.|||                             :..
Mouse   174 CLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNTQFSGHLQNDTLAEQHDQSALPAQEQLR 238

  Fly   347 KKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMT-------------------CEPP 392
            .|:|.|::.:..:||               ||.|:|::.::|                   ..||
Mouse   239 PKSQLEQENIKNTPS---------------DFAKEEVIGMVTRAHKDTFLYNQEHRENSSESMPP 288

  Fly   393 QHA-TIPLLPDEILAKCQARNIPSLTYNQ-------------------LAVIYK---LIWYQDGY 434
            |.. .||            ||:.....||                   |:..||   ::.|.:|:
Mouse   289 QRGERIP------------RNMEQYNLNQDHRGSGIHNHFPCSERQQHLSGQYKGRNIMHYPNGH 341

  Fly   435 E---------QPSEEDLRRIMSQ-PDENESQTD----------------------------VSFR 461
            .         ..|....:|:..: |....|||:                            .|..
Mouse   342 AVCIANGHCMNFSSAYTQRVCDRIPVGGCSQTENRNSYLCNTGGRMHLVCPMSKSPYVDPQKSGH 406

  Fly   462 HITEITILT----VQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFA 522
            .|.|...::    |:.:|||||.:|.|..:.|.||:.||||.:.||:|:|.|..:|....::.|.
Mouse   407 EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFL 471

  Fly   523 NNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQ 586
            :.:.|:.|.....|..|.:..:..|..::.::::.:.|.:|.||:|:.| ||.|:|....|||:|
Mouse   472 SGKKYSVDDLHSMGAGDLLSSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQ 536

  Fly   587 SYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKL 637
            ...|..||..|:..|..::.   .:.|||..|.:||:|.|.::|...:.|:
Mouse   537 ETLIRALRTLIMKNHPNEAS---IFTKLLLKLPDLRSLNNMHSEELLAFKV 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	46/155 (30%)
		NR_LBD_EcR	420..652	CDD:132736	71/283 (25%)
Nr1d2	NP_001412823.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..256		6/45 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..292		3/18 (17%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	404..586		59/184 (32%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:29533925	1..60		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..90		11/44 (25%)