Protein Alignment EcR and Ppard

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_035275.1
• Gene: Ppard / 19015
• MGIID: 101884
• Length: 440
• Species: Mus musculus
• Alignment Length: 477
• Identity: 144/477 - (30%)
• Similarity: 212/477 - (44%)
• Gaps: 83/477 - (17%)

  Fly   198 VGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEE 262
            |.:|.|...:.| |.:||..|.|...:|   .:.||||.|:  .....||   ...|.:..::
Mouse    19 VAMGDGAPELNG-GPEHTLPSSSCADLS---QNSSPSSLLD--QLQMGCD---GASGGSLNME-- 72

  Fly   263 LCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAV 327
             |.||||:|||:||....||||||||||::.....| .|..|.|::....|.|||.||.:||||:
Mouse    73 -CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEY-EKCDRICKIQKKNRNKCQYCRFQKCLAL 135

  Fly   328 GMRPECVVPENQCAMKRREKKAQKEKDK----MTTSPSSQHGGNGSLASGGGQDFVKKEILDLMT 388
            ||....:         |..:..:.||.|    :|.|...||  |..||             ||..
Mouse   136 GMSHNAI---------RFGRMPEAEKRKLVAGLTASEGCQH--NPQLA-------------DLKA 176

  Fly   389 CEPPQHATIPLLPDEILAKCQARNIPSLT----YNQLAVIYK----------LIWYQDGYEQPSE 439
            ..  :|.....|.:..:.|.:||:|  ||    :|...||:.          |:|.|
Mouse   177 FS--KHIYNAYLKNFNMTKKKARSI--LTGKSSHNAPFVIHDIETLWQAEKGLVWKQ-------- 229

  Fly   440 EDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVM 504
                .:...|..||....|.:| ....|:.||:.:.||||.:|.|:.:...||:||||....|.:
Mouse   230 ----LVNGLPPYNEISVHVFYR-CQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAI 289

  Fly   505 MLRMARRYDHSSDSIFFANNRSYTRDSYKMA---GMADNIEDLLHFCRQMFSMKVDNVEYAL-LT 565
            ...:|...  :.|.:..||...:....:..:   ..:|.||....|..:..::::|:.:.|| :.
Mouse   290 FAMLASIV--NKDGLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIA 352

  Fly   566 AIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAE 630
            ||::..|||||.....|||||...:..|..::...| .||..|  :.|||..:.:||.|..::|:
Mouse   353 AIILCGDRPGLMNVPQVEAIQDTILRALEFHLQVNH-PDSQYL--FPKLLQKMADLRQLVTEHAQ 414

  Fly   631 MCFSLKLKNRK--LPKFLEEIW 650
            |...||....:  |...|:||:
Mouse   415 MMQWLKKTESETLLHPLLQEIY 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	37/89 (42%)
		NR_LBD_EcR	420..652	CDD:132736	68/247 (28%)
Ppard	NP_035275.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		13/37 (35%)
		NR_DBD_Ppar	72..155	CDD:143523	39/95 (41%)
		NR_LBD_PPAR	172..439	CDD:132730	80/300 (27%)