Protein Alignment EcR and Ppara

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_035274.2
• Gene: Ppara / 19013
• MGIID: 104740
• Length: 468
• Species: Mus musculus
• Alignment Length: 542
• Identity: 129/542 - (23%)
• Similarity: 219/542 - (40%)
• Gaps: 114/542 - (21%)

  Fly   145 LINSTTPSTPTTPL---------------------HLQQNLGGAGGGGIGGMGILHHANGTPNGL 188
            ::::.:|..|.:||                     .:.|::|....|..|.....:
Mouse     1 MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQY--------- 56

  Fly   189 IGVVGGGGGVGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKK 253
                       ||...|..|                |...|.|||:||.:..|......:.....
Mouse    57 -----------LGSCPGSEG----------------SVITDTLSPASSPSSVSCPVIPASTDESP 94

  Fly   254 GPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQE 318
            |.|..::   |.:|||:||||||....||||||||||::....|| .|..|:|::....|.|||.
Mouse    95 GSALNIE---CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVY-DKCDRSCKIQKKNRNKCQY 155

  Fly   319 CRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEI 383
            ||..|||:|||....:    :.....|.:||:.:.:.:|    .:|            |....|.
Mouse   156 CRFHKCLSVGMSHNAI----RFGRMPRSEKAKLKAEILT----CEH------------DLKDSET 200

  Fly   384 LDLMTCEPPQHATIPLLPDEILAKCQAR--------NIPSLTYNQLAVIYKLIWYQDGYEQPSEE 440
            .||.:.....|..  .|.:..:.|.:||        |.|....:.:..:..           :|:
Mouse   201 ADLKSLGKRIHEA--YLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCM-----------AEK 252

  Fly   441 DLRRIMSQPDENESQTDVSFRHITE-ITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVM 504
            .|...|......:.:.:|.|.|..: :::.||..:.||||.:|.|..:...||:||||....|.:
Mouse   253 TLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAI 317

  Fly   505 MLRMARRYDHSSDSIFFAN---NRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYAL-LT 565
            ...::...:.....|.:.|   .|.:.::..|  ...|.:|....|..:..::::|:.:.:| :.
Mouse   318 FTMLSSLMNKDGMLIAYGNGFITREFLKNLRK--PFCDIMEPKFDFAMKFNALELDDSDISLFVA 380

  Fly   566 AIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTLGNQNAE 630
            ||:...|||||.....:|.:|...:..|::::.:.|..|:.   .:.|||..:.:||.|..::|:
Mouse   381 AIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTF---LFPKLLQKMVDLRQLVTEHAQ 442

  Fly   631 MCFSLKL--KNRKLPKFLEEIW 650
            :...:|.  .:..|...|:||:
Mouse   443 LVQVIKKTESDAALHPLLQEIY 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	40/89 (45%)
		NR_LBD_EcR	420..652	CDD:132736	54/238 (23%)
Ppara	NP_035274.2	NR_DBD_Ppar	101..184	CDD:143523	40/90 (44%)
		NR_LBD_PPAR	201..467	CDD:132730	63/282 (22%)
		Required for heterodimerization with RXRA. /evidence=ECO:0000250	304..433		31/133 (23%)