Protein Alignment EcR and nhr-216

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_001343620.1
• Gene: nhr-216 / 188325
• WormBaseID: WBGene00020385
• Length: 490
• Species: Caenorhabditis elegans
• Alignment Length: 473
• Identity: 94/473 - (19%)
• Similarity: 160/473 - (33%)
• Gaps: 169/473 - (35%)

  Fly   254 GPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFG-RACEMDMYMRRKCQ 317
            ||     ::.|.||...|.|.|:...||..|..||||.|.....|.|... :.|.:|...|..|:
 Worm    56 GP-----KQKCRVCNLEAHGMHFGVQTCRPCAAFFRRIVVLDLKYTCVSNTQKCNVDGRGRNVCR 115

  Fly   318 ECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKE 382
            :||.|||:||||..:.|               |..:|......||..||      |.|:...|:.
 Worm   116 DCRYKKCIAVGMTTDNV---------------QYNRDSHNNKNSSGSGG------GRGRGKNKRN 159

  Fly   383 ILDLMTCEPPQHATIPLLP------DEIL---AKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPS 438
            ::.::|.|.....:..:.|      ||..   .....|..|.|              ....|:..
 Worm   160 VMMMLTDEEEAAGSSTVKPGGSIKGDESFCSDGSSSTRGNPQL--------------DPDAERRD 210

  Fly   439 EEDLRRIMS---------QPDENESQTDVSFRHITEITILTVQLI-----------VEFAKGLPA 483
            :|::.:|:|         .|.|..:|..     |.::..||..|:           ::|...:.|
 Worm   211 DEEMDKIISDLKHLFVEYSPPEMINQCS-----INQLQRLTHSLVLYRQNQQSANQIKFCDTINA 270

  Fly   484 FT------------------------KIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANN 524
            ||                        |:..|.:|..:|      |...:..|.:.:..|:.....
 Worm   271 FTDGKAHLQRKSEKFSKWVKCVDFFDKLSDEQKIDTVK------MSFTVFDRLERAQMSVKIFGE 329

  Fly   525 RSYTR-----------------------------DSYKMAGMADNIEDLL-HFCRQMFSMKVDNV 559
            :|.|.                             ::|..|....:::.:: ..|:.::.:::.:.
 Worm   330 KSITEKKTTLSSYCAVDWKNVKINPETAINTEQANNYVKAEFHAHVDSIIDEVCKPLYELQLSDT 394

  Fly   560 EYA-LLTAIVIFSD----RPGLEKA--QLVEAIQS----YY-------IDTLRIYILNRHCGDSM 606
            |.| :|..::::..    .|.|.|.  ||.|.|.:    ||       .||.||
 Worm   395 ETAFILVQVLVYHGGEKVTPELVKMFDQLRETIATDLHLYYTKESQTGTDTNRI----------- 448

  Fly   607 SLVFYAKLLSILTELRTL 624
                 .|::|::..::.:
 Worm   449 -----LKMMSVVNAMKKI 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	30/90 (33%)
		NR_LBD_EcR	420..652	CDD:132736	45/297 (15%)
nhr-216	NP_001343620.1	ZnF_C4	60..130	CDD:197701	29/69 (42%)
		Hormone_recep	287..462	CDD:459675	30/197 (15%)