Protein Alignment EcR and nhr-130

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_503216.1
• Gene: nhr-130 / 187965
• WormBaseID: WBGene00003720
• Length: 440
• Species: Caenorhabditis elegans
• Alignment Length: 463
• Identity: 95/463 - (20%)
• Similarity: 165/463 - (35%)
• Gaps: 142/463 - (30%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSVT-KSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAV 327
            |.||...|.|.|:.|::|..|..||||:.| ....|.||....|::....|.||::|||.:|..|
 Worm    37 CQVCALPAHGNHFGAISCRACAAFFRRACTGTKTTYKCKKQNNCDIWENGRYKCKKCRLDRCNEV 101

  Fly   328 GMRPECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASG------------GGQDFV- 379
            ||.|               .:.|.::|.::.:....:..|.....|            |...|:
 Worm   102 GMDP---------------GRFQFDRDLISATEKYPNSKNFRRTFGMSRLPETIEHFLGRPHFII 151

  Fly   380 ----------KKEILDLMTCEPPQHATIPLLPDEILAKCQ------------ARNIPSLTYNQLA 422
                      :|..:||      ||         ::||..            |||    ...:||
 Worm   152 FLERHIYSHSEKNFVDL------QH---------LIAKASKLLELGSEKPLIARN----NLEKLA 197

  Fly   423 VIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTK- 486
            :...|:     .:||:.....:::::..::|:.|      ..|...|||      ||.|..|..
 Worm   198 LGLNLV-----RDQPAGSHDVQLVTKLGKDEALT------FWETDFLTV------AKWLTYFDDF 245

  Fly   487 --IPQEDQITLLKA----------------------CSSEVMMLRMARRYDHSSDSIFFANNRSY 527
              :|...||.|||:                      |..:.:||......:..:..:.::....|
 Worm   246 QLLPHNQQILLLKSVWHVWNRLEKLALTATSRRQNVCEQKQLMLTYNSVCNPKTIELDYSWFTKY 310

  Fly   528 TRDSYKMAGMADNIED--LLHFCRQMFSMKVDNVEYALLTAIVIF---SDRPGLEKAQLVEAIQS 587
            .::  ::....|.:||  |......:.|::..::|...:...:.|   ..|.|.|..::.|..|.
 Worm   311 PKE--QLCFFFDEMEDYMLTSALDPLTSLEPTDIELTYMLCQLCFHYAGKRYGGEILEVTEKFQE 373

  Fly   588 YYIDTLRIYILN-----RHCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLE 647
            ...|.|..|.:|     |:||.             |.::..:.|...:..:..:.|:.     |.
 Worm   374 NLADNLHDYYVNELNMPRYCGR-------------LNQMLKINNLIQQDIWEKRAKHE-----LA 420

  Fly   648 EIWDVHAI 655
            :::|:..|
 Worm   421 KVFDIFCI 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	29/87 (33%)
		NR_LBD_EcR	420..652	CDD:132736	48/266 (18%)
nhr-130	NP_503216.1	ZnF_C4	36..105	CDD:197701	28/67 (42%)
		Hormone_recep	210..410	CDD:459675	41/226 (18%)