Protein Alignment EcR and nhr-211

DIOPT Version :10

• Sequence 1: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Sequence 2: NP_503218.1
• Gene: nhr-211 / 187963
• WormBaseID: WBGene00020152
• Length: 383
• Species: Caenorhabditis elegans
• Alignment Length: 450
• Identity: 89/450 - (19%)
• Similarity: 164/450 - (36%)
• Gaps: 138/450 - (30%)

  Fly   264 CLVCGDRASGYHYNALTCEGCKGFFRRSV-TKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAV 327
            |.:|...|.|.|:.||||..|..||||:: .|.....||.|..|........:|:.||::|||.|
 Worm     5 CGICDAPAHGRHFGALTCLSCAAFFRRAIFAKKKRKSCKSGNKCRDFNGNFPQCKSCRMRKCLRV 69

  Fly   328 GMR------PECVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDL 386
            ||:      |...:|::.                                    :.||.:..:.|
 Worm    70 GMKLESKSPPPAAIPQSL------------------------------------EVFVSRPSMIL 98

  Fly   387 MTCEPPQHATIPLLPDEILAKCQARN---IPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQ 448
            ...:|                .|.||   :.:|....|:::      :.|.:.|..:.|..:...
 Worm    99 FANKP----------------SQTRNFIDVSNLVARGLSIL------KHGAQSPLNQKLTSLEKM 141

  Fly   449 PDENESQTDVSFRHITEITILTVQLIVEF--------AKGLPAFTKIPQEDQITLL--------- 496
            .... |.:...|..:.|:|...|..:.||        ...|..|:::|.:.::.:|
 Worm   142 ALAG-SPSMKKFMKVNEVTSKYVAKVWEFDFITAARCLANLDGFSELPDKLKMQILQSIWHVWAR 205

  Fly   497 --KACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNV 559
              ||..|    .::.:|....|:::..::|.....::.:|        |:....|..|    |.|
 Worm   206 LFKAARS----AQLRKRQGLFSNALQISDNLYVEMETIRM--------DVTWLTRYSF----DQV 254

  Fly   560 EYALLTAIVIFSDRPGLEK-AQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSIL-TELR 622
            :|.|.          |:|: :.|.::|:|  :..|.:        ..:.|::....||.| .:.|
 Worm   255 KYFLY----------GVEEDSYLKDSIES--LTKLEL--------TEIELIYMTAQLSFLYAQNR 299

  Fly   623 TLGNQNAEMCFSLK------LKN------RKLPKFLEEIWDVHAIPPSVQSHLQITQEEN 670
            ..|.:..|:|..|:      |.|      :|...::..:..:..|..|:..:::.|:|.:
 Worm   300 FSGTEIGEICEKLQDGLGNDLHNYYTKPEKKNRNYVGRLTQMLKINFSLMKNIRTTRERS 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	30/93 (32%)
		NR_LBD_EcR	420..652	CDD:132736	47/264 (18%)
nhr-211	NP_503218.1	ZnF_C4	4..74	CDD:197701	28/68 (41%)
		Hormone_recep	148..352	CDD:459675	44/239 (18%)